RNA-Seq gene expression estimation with read mapping uncertainty

Motivation: RNA-Seq is a promising new technology for accurately measuring gene expression levels. Expression estimation with RNA-Seq requires the mapping of relatively short sequencing reads to a reference genome or transcript set. Because reads are generally shorter than transcripts from which the...

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Bibliographic Details
Published in:	Bioinformatics Vol. 26; no. 4; pp. 493 - 500
Main Authors:	Li, Bo, Ruotti, Victor, Stewart, Ron M., Thomson, James A., Dewey, Colin N.
Format:	Journal Article
Language:	English
Published:	Oxford Oxford University Press 15.02.2010
Subjects:	Algorithms Animals Base Sequence Biological and medical sciences Computational Biology - methods Databases, Genetic Fundamental and applied biological sciences. Psychology Gene Expression Gene Expression Profiling General aspects Genome Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Mice Original Papers Sequence Analysis, RNA - methods Software Zea mays Zea mays - genetics Genetic mapping Gene RNA High throughput sequencing Estimation Mapping Gene expression
ISSN:	1367-4803, 1367-4811, 1460-2059, 1367-4811
Online Access:	Get full text
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