In vivo performance of Al2O3-Ti bone implants in the rat femur

Background Alumina-titanium (Al 2 O 3 -Ti) biocomposites have been recently developed with improved mechanical properties for use in heavily loaded orthopedic sites. Their biological performance, however, has not been investigated yet. Methods The aim of the present study was to evaluate the in vivo...

Full description

Saved in:
Bibliographic Details
Published in:Journal of orthopaedic surgery and research Vol. 16; no. 1; pp. 1 - 14
Main Authors: Bahraminasab, Marjan, Arab, Samaneh, Safari, Manouchehr, Talebi, Athar, Kavakebian, Fatemeh, Doostmohammadi, Nesa
Format: Journal Article
Language:English
Published: London BioMed Central 22.01.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Alumina
Aluminum oxide
Biological products
Blood vessels
Bone formation
Bone growth
Bone healing
Bone implants
Bone remodeling
Bones
Composites
Femur
Fractures
In vivo
Interfaces
Lamellar bone
Mechanical properties
Medicine
Medicine & Public Health
Neovascularization
Orthopedic biomaterials
Orthopedics
Osteocytes
Osteogenesis
Physiology
Plasma sintering
Research Article
Scanning electron microscopy
Surgery
Surgical Orthopedics
Titanium
Transplants & implants
In vivo
Osteocytes
Composites
Bone formation
Orthopedic biomaterials
ISSN:1749-799X, 1749-799X
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Alumina-titanium (Al 2 O 3 -Ti) biocomposites have been recently developed with improved mechanical properties for use in heavily loaded orthopedic sites. Their biological performance, however, has not been investigated yet. Methods The aim of the present study was to evaluate the in vivo biological interaction of Al 2 O 3 -Ti. Spark plasma sintering (SPS) was used to fabricate Al 2 O 3 -Ti composites with 25 vol.%, 50 vol.%, and 75 vol.% Ti content. Pure alumina and titanium were also fabricated by the same procedure for comparison. The fabricated composite disks were cut into small bars and implanted into medullary canals of rat femurs. The histological analysis and scanning electron microscopy (SEM) observation were carried out to determine the bone formation ability of these materials and to evaluate the bone-implant interfaces. Results The histological observation showed the formation of osteoblast, osteocytes with lacuna, bone with lamellar structures, and blood vessels indicating that the healing and remodeling of the bone, and vasculature reconstruction occurred after 4 and 8 weeks of implantation. However, superior bone formation and maturation were obtained after 8 weeks. SEM images also showed stronger interfaces at week 8. There were differences between the composites in percentages of bone area (TB%) and the number of osteocytes. The 50Ti composite showed higher TB% at week 4, while 25Ti and 75Ti represented higher TB% at week 8. All the composites showed a higher number of osteocytes compared to 100Ti, particularly 75Ti. Conclusions The fabricated composites have the potential to be used in load-bearing orthopedic applications.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1749-799X
1749-799X
DOI:10.1186/s13018-021-02226-7