Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells

The generation of induced pluripotent stem cells (iPSC) from adult somatic cells is one of the most remarkable discoveries in recent decades. However, several works have reported evidence of genomic instability in iPSC, raising concerns on their biomedical use. The reasons behind the genomic instabi...

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Veröffentlicht in:	Nature communications Jg. 6; H. 1; S. 8036
Hauptverfasser:	Ruiz, Sergio, Lopez-Contreras, Andres J., Gabut, Mathieu, Marion, Rosa M., Gutierrez-Martinez, Paula, Bua, Sabela, Ramirez, Oscar, Olalde, Iñigo, Rodrigo-Perez, Sara, Li, Han, Marques-Bonet, Tomas, Serrano, Manuel, Blasco, Maria A., Batada, Nizar N., Fernandez-Capetillo, Oscar
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 21.08.2015 Nature Publishing Group Nature Pub. Group
Schlagworte:	13/100 13/44 631/208/211 631/337/1427 631/532/2064/2158 631/80/86/2366 Animals Biochemistry, Molecular Biology Biologia molecular Cell Line Cell Proliferation - physiology Cellular Biology Cellular Reprogramming - physiology Checkpoint Kinase 1 Citologia DNA - genetics Fibroblasts - physiology Gene Expression Regulation - physiology Genomic Instability - physiology Genomics Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - physiology Life Sciences Mice Mice, Transgenic multidisciplinary Nucleic Acid Hybridization Plasmids Point Mutation Protein Kinases - genetics Protein Kinases - metabolism Science Science (multidisciplinary) Stem cells Stress, Physiological - physiology Subcellular Processes
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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