Relaxed Selection Drives a Noisy Noncoding Transcriptome in Members of the Mycobacterium tuberculosis Complex

Related species are often used to understand the molecular underpinning of virulence through examination of a shared set of biological features attributable to a core genome of orthologous genes. An important but insufficiently studied issue, however, is the extent to which the regulatory architectu...

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Bibliographic Details
Published in:	mBio Vol. 5; no. 4; p. e01169
Main Authors:	Dinan, Adam M., Tong, Pin, Lohan, Amanda J., Conlon, Kevin M., Miranda-CasoLuengo, Aleksandra A., Malone, Kerri M., Gordon, Stephen V., Loftus, Brendan J.
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 05.08.2014 American Society of Microbiology
Subjects:	Evolution Evolution, Molecular Genes Genome, Bacterial - genetics Genomes Genomics Host preferences Multidrug resistance multiple drug resistance Mycobacterium marinum Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics non-coding RNA Pathogenicity Pathogens Polymorphism, Single Nucleotide - genetics promoter regions Promoter Regions, Genetic - genetics Single-nucleotide polymorphism Species Transcription transcription (genetics) transcription factors transcriptome Transcriptome - genetics Transcriptomes Tuberculosis Virulence
ISSN:	2161-2129, 2150-7511, 2150-7511
Online Access:	Get full text
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