The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies

Given that hypoxia is a persistent physiological feature of many different solid tumors and a key driver for cancer malignancy, it is thought to be a major target in cancer treatment recently. Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME),...

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Bibliographic Details
Published in:	Molecular cancer Vol. 21; no. 1; pp. 1 - 22
Main Authors:	Bai, Ruixue, Li, Yunong, Jian, Lingyan, Yang, Yuehui, Zhao, Lin, Wei, Minjie
Format:	Journal Article
Language:	English
Published:	London BioMed Central 08.09.2022 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Biomedical and Life Sciences Biomedicine Blood Blood vessels Cancer Cancer Research Care and treatment Cell interactions Chemokines Communication Development and progression Exosomes Gene expression Hypoxia Hypoxia-inducible factor Immunotherapy Inhibitor Intercellular communication Literature reviews Macrophages Malignancy Medical prognosis Metabolism Molecular modelling Oncology Oxygen sensor Phenotypes Review Solid tumors Tumor cells Tumor microenvironment Tumorigenesis Tumors Hypoxia-inducible factor Oxygen sensor Inhibitor Intercellular communication
ISSN:	1476-4598, 1476-4598
Online Access:	Get full text
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