Functions of EpCAM in physiological processes and diseases (Review)

EpCAM (epithelial cell adhesion molecule) is a type I transmembrane glycoprotein, which was originally identified as a tumor-associated antigen due to its high expression level in rapidly growing epithelial tumors. Germ line mutations of the human EpCAM gene have been indicated as the cause of conge...

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Vydáno v:	International journal of molecular medicine Ročník 42; číslo 4; s. 1771 - 1785
Hlavní autoři:	Huang, Li, Yang, Yanhong, Yang, Fei, Liu, Shaomin, Zhu, Ziqin, Lei, Zili, Guo, Jiao
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Greece D.A. Spandidos 01.10.2018 Spandidos Publications Spandidos Publications UK Ltd
Témata:	Animals cancer Cell adhesion & migration Cell Adhesion - genetics Cell adhesion molecules Cell Movement Cell Proliferation cell-cell junctions congenital tufting enteropathy Disease susceptibility epithelial cell adhesion molecule Epithelial Cell Adhesion Molecule - genetics Epithelial Cell Adhesion Molecule - metabolism Gene expression Genetic aspects Health aspects Humans Medical research Mutation Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - metabolism Rodents Signal Transduction Small intestine stem cell Zebrafish
ISSN:	1107-3756, 1791-244X, 1791-244X
On-line přístup:	Získat plný text
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Popis
Shrnutí:	EpCAM (epithelial cell adhesion molecule) is a type I transmembrane glycoprotein, which was originally identified as a tumor-associated antigen due to its high expression level in rapidly growing epithelial tumors. Germ line mutations of the human EpCAM gene have been indicated as the cause of congenital tufting enteropathy. Previous studies based on cell models have revealed that EpCAM contributes to various biological processes including cell adhesion, signaling, migration and proliferation. Due to the previous lack of genetic animal models, the in vivo functions of EpCAM remain largely unknown. However, EpCAM genetic animal models have recently been generated, and are useful for understanding the functions of EpCAM. The authors here briefly review the functions and mechanisms of EpCAM in physiological processes and different diseases.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Contributed equally
ISSN:	1107-3756 1791-244X 1791-244X
DOI:	10.3892/ijmm.2018.3764