The healing of bone defects by cell-free and stem cell-seeded 3D-printed PLA tissue-engineered scaffolds

In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed th...

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Bibliographic Details
Published in:Journal of orthopaedic surgery and research Vol. 17; no. 1; pp. 1 - 17
Main Authors: Bahraminasab, Marjan, Talebi, Athar, Doostmohammadi, Nesa, Arab, Samaneh, Ghanbari, Ali, Zarbakhsh, Sam
Format: Journal Article
Language:English
Published: London BioMed Central 20.06.2022
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
3D printing
Biocompatibility
Biopolymers
Bone growth
Bone healing
Bone marrow-derived mesenchymal stem cells (BMSCs)
Bones
Calvaria
Comparative analysis
Connective tissues
Critical-sized defect
Defects
FDA approval
Humidity
Laboratory animals
Medicine
Medicine & Public Health
Mesenchymal stem cells
Morphology
Orthopedics
Osteogenesis
Polylactic acid
Povidone
Scanning electron microscopy
Stem cells
Surgical Orthopedics
Tissue engineering
Transplants & implants
Bone marrow-derived mesenchymal stem cells (BMSCs)
Bone healing
3D printing
Critical-sized defect
Polylactic acid
ISSN:1749-799X, 1749-799X
Online Access:Get full text
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Summary:In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively. The higher filled area, bone formation and bone maturation were observed after 12 weeks, particularly for PLA + Cell scaffolds.
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ISSN:1749-799X
1749-799X
DOI:10.1186/s13018-022-03213-2