The healing of bone defects by cell-free and stem cell-seeded 3D-printed PLA tissue-engineered scaffolds

In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed th...

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Veröffentlicht in:	Journal of orthopaedic surgery and research Jg. 17; H. 1; S. 1 - 17
Hauptverfasser:	Bahraminasab, Marjan, Talebi, Athar, Doostmohammadi, Nesa, Arab, Samaneh, Ghanbari, Ali, Zarbakhsh, Sam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 20.06.2022 BioMed Central Ltd Springer Nature B.V BMC
Schlagworte:	3D printing Biocompatibility Biopolymers Bone growth Bone healing Bone marrow-derived mesenchymal stem cells (BMSCs) Bones Calvaria Comparative analysis Connective tissues Critical-sized defect Defects FDA approval Humidity Laboratory animals Medicine Medicine & Public Health Mesenchymal stem cells Morphology Orthopedics Osteogenesis Polylactic acid Povidone Scanning electron microscopy Stem cells Surgical Orthopedics Tissue engineering Transplants & implants Bone marrow-derived mesenchymal stem cells (BMSCs) Bone healing 3D printing Critical-sized defect Polylactic acid
ISSN:	1749-799X, 1749-799X
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Abstract	In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively. The higher filled area, bone formation and bone maturation were observed after 12 weeks, particularly for PLA + Cell scaffolds.
AbstractList	In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively. The higher filled area, bone formation and bone maturation were observed after 12 weeks, particularly for PLA + Cell scaffolds. In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively. The higher filled area, bone formation and bone maturation were observed after 12 weeks, particularly for PLA + Cell scaffolds. Abstract In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively. The higher filled area, bone formation and bone maturation were observed after 12 weeks, particularly for PLA + Cell scaffolds. In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively. The higher filled area, bone formation and bone maturation were observed after 12 weeks, particularly for PLA + Cell scaffolds. Keywords: 3D printing, Bone healing, Critical-sized defect, Polylactic acid, Bone marrow-derived mesenchymal stem cells (BMSCs) In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively. The higher filled area, bone formation and bone maturation were observed after 12 weeks, particularly for PLA + Cell scaffolds.In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively. The higher filled area, bone formation and bone maturation were observed after 12 weeks, particularly for PLA + Cell scaffolds.
ArticleNumber	320
Audience	Academic
Author	Zarbakhsh, Sam Doostmohammadi, Nesa Talebi, Athar Ghanbari, Ali Arab, Samaneh Bahraminasab, Marjan
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Keywords	Bone marrow-derived mesenchymal stem cells (BMSCs) Bone healing 3D printing Critical-sized defect Polylactic acid
Language	English
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Snippet	In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone.... Abstract In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat...
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SubjectTerms	3D printing Biocompatibility Biopolymers Bone growth Bone healing Bone marrow-derived mesenchymal stem cells (BMSCs) Bones Calvaria Comparative analysis Connective tissues Critical-sized defect Defects FDA approval Humidity Laboratory animals Medicine Medicine & Public Health Mesenchymal stem cells Morphology Orthopedics Osteogenesis Polylactic acid Povidone Scanning electron microscopy Stem cells Surgical Orthopedics Tissue engineering Transplants & implants
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Title	The healing of bone defects by cell-free and stem cell-seeded 3D-printed PLA tissue-engineered scaffolds
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