Atlas of regulated target genes of transcription factors (ART-TF) in human ES cells

Background Transcription factors (TFs) play central roles in maintaining “stemness” of embryonic stem (ES) cells and their differentiation into several hundreds of adult cell types. The regulatory competence of TFs is routinely assessed by detecting target genes to which they bind. However, these da...

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Bibliographic Details
Published in:	BMC bioinformatics Vol. 23; no. 1; pp. 1 - 19
Main Authors:	Sharov, Alexei A., Nakatake, Yuhki, Wang, Weidong
Format:	Journal Article
Language:	English
Published:	London BioMed Central 16.09.2022 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Algorithms Analysis Binding Binding sites Bioinformatics Biomedical and Life Sciences Cell differentiation Cloning Computational Biology/Bioinformatics Computer Appl. in Life Sciences DNA testing Embryonic stem cells Enhancer-promoter loop Enhancers Experiments Gene expression Gene silencing Genes Genetic aspects Genetic engineering Genome binding of transcription factors Genomes Induction of transcription factors Life Sciences Methods Microarrays Parametric analysis of gene expression Parametric statistics Protein synthesis Proteins Regenerative medicine Regulated target genes Repressors Signal transduction Statistical analysis Target detection Transcription activation Transcription factors United States Regulated target genes Genome binding of transcription factors Induction of transcription factors Embryonic stem cells Parametric analysis of gene expression Enhancer-promoter loop
ISSN:	1471-2105, 1471-2105
Online Access:	Get full text
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