Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES

Background Diet has long been hypothesized to play an important role in hyperuricemia, and weight gain is a factor that is strongly associated with the rise in serum urate. We aimed to clarify the mediating role of obesity in the relationship between diet and hyperuricemia and to determine whether a...

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Vydané v:BMC public health Ročník 22; číslo 1; s. 1 - 12
Hlavní autori: Wang, Juping, Chen, Shuting, Zhao, Junkang, Liang, Jie, Gao, Xue, Gao, Qian, He, Simin, Wang, Tong
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 28.10.2022
BioMed Central Ltd
Springer Nature B.V
BMC
Predmet:
Adipose tissue
Biostatistics
Blood pressure
Body mass index
Body size
Body weight gain
Body weight loss
Cardiovascular disease
Cholesterol
Diabetes
Diet
Environmental Health
Epidemiology
Gastrointestinal surgery
Health aspects
High fat diet
Hypertension
Hyperuricemia
Indicators
Laboratories
Lipids
Low fat diet
Males
Mediation analysis
Medicine
Medicine & Public Health
Nutrient deficiency
Nutrients
Nutrition research
Obesity
Prevention
Principal component analysis
Principal components analysis
Public Health
Reduced rank regression
Regression
Rheumatism
Risk factors
Thiamine
Triglycerides
Uric acid
Vaccine
Variables
Vitamin A
Womens health
United States
United States > US
Obesity
Hyperuricemia
Reduced rank regression
Mediation analysis
Principal component analysis
ISSN:1471-2458, 1471-2458
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Shrnutí:Background Diet has long been hypothesized to play an important role in hyperuricemia, and weight gain is a factor that is strongly associated with the rise in serum urate. We aimed to clarify the mediating role of obesity in the relationship between diet and hyperuricemia and to determine whether a weight-loss diet is an effective way to prevent hyperuricemia. Methods This cross-sectional study analysed representative samples of United States ( n  = 20,081; NHANES 2007–2016) adults. Nutrient patterns were derived with two methods: principal component analysis (PCA) and reduced rank regression (RRR) with obesity. Logistic regression and multivariable linear regression were applied to analyse the association between nutrient patterns in obesity and hyperuricemia. Mediation analyses were used to determine whether four obesity indicators, including body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI) and lipid accumulation product index (LAP), mediated the relationship between nutrient patterns and hyperuricemia. Results PCA revealed three nutrient patterns (including “Low energy diet”, “Lower vitamin A, C, K pattern” and “Vitamin B group”), and only Vitamin B group had a total effect on hyperuricemia. RRR revealed one main nutrient pattern associated with obesity, which was characterized by High fat and low vitamin levels and was significantly associated with hyperuricemia. Mediation analysis showed that obesity mostly or even completely mediated the relationship between nutrient patterns and hyperuricemia, especially traditional obesity indicators, which played a key intermediary effect. The proportions of indirect effects for BMI and WC were as high as 53.34 and 59.69, respectively. Conclusions Our findings suggest that the direct effect of diet on hyperuricemia is weak, and obesity plays a critical mediating role in the relationship between diet and hyperuricemia, which confirms that a weight-loss diet such as a “Low fat and high vitamin diet” may be useful in preventing hyperuricemia.
Bibliografia:ObjectType-Article-1
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ISSN:1471-2458
1471-2458
DOI:10.1186/s12889-022-14357-5