Myeloid liver kinase B1 contributes to lung inflammation induced by lipoteichoic acid but not by viable Streptococcus pneumoniae

Background Liver kinase B1 (Lkb1, gene name Stk11 ) functions as a tumor suppressor in cancer. Myeloid cell Lkb1 potentiates lung inflammation induced by the Gram-negative bacterial cell wall component lipopolysaccharide and in host defense during Gram-negative pneumonia. Here, we sought to investig...

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Bibliographic Details
Published in:	Respiratory research Vol. 23; no. 1; pp. 1 - 11
Main Authors:	Pereverzeva, Liza, Otto, Natasja A., Roelofs, Joris J. T. H., de Vos, Alex F., van der Poll, Tom
Format:	Journal Article
Language:	English
Published:	London BioMed Central 12.09.2022 BioMed Central Ltd Nature Publishing Group BMC
Subjects:	Alveolar bone Alveolar macrophages Analysis Bacteria Bone marrow Care and treatment Cell walls Chemokines Cloning Cytokines Diagnosis Encapsulation Experiments Flow cytometry Gene expression Gram-negative bacteria Gram-positive bacteria Histopathology Inflammation Kinases Leukocytes (neutrophilic) Lipopolysaccharides Lipoteichoic acid Liver Liver kinase B1 LKB1 protein Lungs Macrophages Medicine Medicine & Public Health Pathogens Pathology Pneumology/Respiratory System Pneumonia Prevention Respiratory tract infections Risk factors Streptococcal infections Streptococcus infections Streptococcus pneumoniae Tumor necrosis factor-α Tumor suppressor genes Netherlands Basel Switzerland Switzerland Germany Pneumonia Liver kinase B1 Alveolar macrophages Lipoteichoic acid
ISSN:	1465-993X, 1465-9921, 1465-993X
Online Access:	Get full text
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