Accelerated epigenetic aging in Down syndrome

Summary Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. He...

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Vydáno v:	Aging cell Ročník 14; číslo 3; s. 491 - 495
Hlavní autoři:	Horvath, Steve, Garagnani, Paolo, Bacalini, Maria Giulia, Pirazzini, Chiara, Salvioli, Stefano, Gentilini, Davide, Di Blasio, Anna Maria, Giuliani, Cristina, Tung, Spencer, Vinters, Harry V., Franceschi, Claudio
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England John Wiley & Sons, Inc 01.06.2015 BlackWell Publishing Ltd
Témata:	Adult Aged Aging - genetics biomarker of aging Biomarkers - analysis DNA methylation DNA Methylation - genetics Down syndrome Down Syndrome - genetics Down Syndrome - metabolism Epigenesis, Genetic epigenetics Epigenomics - methods Humans Middle Aged Original Young Adult DNA methylation Down syndrome biomarker of aging epigenetics
ISSN:	1474-9718, 1474-9726, 1474-9726
On-line přístup:	Získat plný text
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