Accelerated epigenetic aging in Down syndrome

Summary Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. He...

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Veröffentlicht in:Aging cell Jg. 14; H. 3; S. 491 - 495
Hauptverfasser: Horvath, Steve, Garagnani, Paolo, Bacalini, Maria Giulia, Pirazzini, Chiara, Salvioli, Stefano, Gentilini, Davide, Di Blasio, Anna Maria, Giuliani, Cristina, Tung, Spencer, Vinters, Harry V., Franceschi, Claudio
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England John Wiley & Sons, Inc 01.06.2015
BlackWell Publishing Ltd
Schlagworte:
Adult
Aged
Aging - genetics
biomarker of aging
Biomarkers - analysis
DNA methylation
DNA Methylation - genetics
Down syndrome
Down Syndrome - genetics
Down Syndrome - metabolism
Epigenesis, Genetic
epigenetics
Epigenomics - methods
Humans
Middle Aged
Original
Young Adult
DNA methylation
Down syndrome
biomarker of aging
epigenetics
ISSN:1474-9718, 1474-9726, 1474-9726
Online-Zugang:Volltext
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Zusammenfassung:Summary Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10−14).
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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These authors contributed equally.
ISSN:1474-9718
1474-9726
1474-9726
DOI:10.1111/acel.12325