Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis

Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear. Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single cells from 15 paired samples of primary tumors and axillary lymph nodes. We identified nine cancer cell subclusters including C...

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Bibliographic Details
Published in:	Oncogenesis (New York, NY) Vol. 10; no. 10; pp. 66 - 12
Main Authors:	Xu, Kun, Wang, Runtian, Xie, Hui, Hu, Longfei, Wang, Cong, Xu, Jiali, Zhu, Chengjun, Liu, Yiqiu, Gao, Fangyan, Li, Xintong, Wang, Cenzhu, Huang, Jinyi, Zhou, Wenbin, Zhou, Guohua, Shu, Yongqian, Guan, Xiaoxiang
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05.10.2021 Nature Publishing Group
Subjects:	38/39 631/67/1347 631/67/2329 Aldehyde dehydrogenase Apoptosis Breast cancer CD44 antigen Cell Biology Human Genetics Internal Medicine Lymph nodes Lymphatic system Medicine Medicine & Public Health Metastases Metastasis Molecular modelling Oncology Stem cells Transcriptomes Tumor microenvironment Tumors
ISSN:	2157-9024, 2157-9024
Online Access:	Get full text
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