MALDI imaging mass spectrometry: Spatial molecular analysis to enable a new age of discovery

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) combines the sensitivity and selectivity of mass spectrometry with spatial analysis to provide a new dimension for histological analyses to provide unbiased visualization of the arrangement of biomolecules in tissue. A...

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Bibliographic Details
Published in:Journal of proteomics Vol. 107; pp. 71 - 82
Main Authors: Gessel, Megan M., Norris, Jeremy L., Caprioli, Richard M.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 31.07.2014
Subjects:
desorption
Drug Discovery
drugs
History, 20th Century
History, 21st Century
Humans
image analysis
ionization
MALDI imaging mass spectrometry
mass spectrometry
molecular weight
Proteins
proteomics
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - history
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
MALDI imaging mass spectrometry
ISSN:1874-3919, 1876-7737, 1876-7737
Online Access:Get full text
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Summary:Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) combines the sensitivity and selectivity of mass spectrometry with spatial analysis to provide a new dimension for histological analyses to provide unbiased visualization of the arrangement of biomolecules in tissue. As such, MALDI IMS has the capability to become a powerful new molecular technology for the biological and clinical sciences. In this review, we briefly describe several applications of MALDI IMS covering a range of molecular weights, from drugs to proteins. Current limitations and challenges are discussed along with recent developments to address these issues. This article is part of a Special Issue entitled: 20years of Proteomics in memory of Vitaliano Pallini. Guest Editors: Luca Bini, Juan J. Calvete, Natacha Turck, Denis Hochstrasser and Jean-Charles Sanchez. [Display omitted] •MALDI IMS has the capability to become a powerful new molecular technology for the bioligcal and clinical sciences.•Applications of MALDI IMS are described, covering a range of molecular weights, from drugs to proteins.•Current limitations and challenges are discussed, as well as recent developments that address these issues.
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ISSN:1874-3919
1876-7737
1876-7737
DOI:10.1016/j.jprot.2014.03.021