Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer

Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein p63 (TP63) , a master transcription factor (TF) and a well-researched SCC-specific oncogene. In the present study, both Gene S...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 4362 - 17
Main Authors:	Li, Li-Yan, Yang, Qian, Jiang, Yan-Yi, Yang, Wei, Jiang, Yuan, Li, Xiang, Hazawa, Masaharu, Zhou, Bo, Huang, Guo-Wei, Xu, Xiu-E, Gery, Sigal, Zhang, Ying, Ding, Ling-Wen, Ho, Allen S., Zumsteg, Zachary S., Wang, Ming-Rong, Fullwood, Melissa J., Freedland, Stephen J., Meltzer, Stephen J., Xu, Li-Yan, Li, En-Min, Koeffler, H. Phillip, Lin, De-Chen
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16.07.2021 Nature Publishing Group Nature Portfolio
Subjects:	13/109 13/44 13/51 13/89 14/105 14/19 38/88 38/91 45/77 49/15 49/23 631/208 631/67/1813/1352 631/67/68/2486 64/60 82/80 Biosynthesis Cancer Epigenetics ErbB protein Fatty acids Gene set enrichment analysis Humanities and Social Sciences Krueppel-like factor Lipid metabolism Lipids Liquid chromatography Mass spectrometry Mass spectroscopy Metabolism Molecular modelling multidisciplinary Regulatory sequences Science Science (multidisciplinary) Sphingolipids Squamous cell carcinoma Therapeutic targets TOR protein Transcription factors Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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