Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

Tryptophan catabolism by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2 (IDO/TDO) promotes immunosuppression across different cancer types. The tryptophan metabolite L-Kynurenine (Kyn) interacts with the ligand-activated transcription factor aryl hydrocarbon receptor (AHR...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 4011 - 11
Main Authors:	Campesato, Luis Felipe, Budhu, Sadna, Tchaicha, Jeremy, Weng, Chien-Huan, Gigoux, Mathieu, Cohen, Ivan Jose, Redmond, David, Mangarin, Levi, Pourpe, Stephane, Liu, Cailian, Zappasodi, Roberta, Zamarin, Dmitriy, Cavanaugh, Jill, Castro, Alfredo C., Manfredi, Mark G., McGovern, Karen, Merghoub, Taha, Wolchok, Jedd D.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11.08.2020 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/109 13/21 13/31 38 38/77 38/88 42 45 631/250/251/1574 631/250/580 631/67/327 64 64/60 Aromatic compounds Catabolism CD8 antigen Humanities and Social Sciences Hydrocarbons Immune checkpoint inhibitors Immunosuppression Immunotherapy Inhibitors Ligands Lymphocytes Lymphocytes T Macrophages Metabolites multidisciplinary Myeloid cells PD-1 protein Receptors Science Science (multidisciplinary) Tryptophan Tryptophan 2,3-dioxygenase Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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