Second-look surgery plus hyperthermic intraperitoneal chemotherapy versus surveillance in patients at high risk of developing colorectal peritoneal metastases (PROPHYLOCHIP–PRODIGE 15): a randomised, phase 3 study

Diagnosis and treatment of colorectal peritoneal metastases at an early stage, before the onset of signs, could improve patient survival. We aimed to compare the survival benefit of systematic second-look surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC), with surveillance, in patients...

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Vydáno v:	The lancet oncology Ročník 21; číslo 9; s. 1147 - 1154
Hlavní autoři:	Goéré, Diane, Glehen, Olivier, Quenet, François, Guilloit, Jean-Marc, Bereder, Jean-Marc, Lorimier, Gérard, Thibaudeau, Emilie, Ghouti, Laurent, Pinto, Amandine, Tuech, Jean-Jacques, Kianmanesh, Reza, Carretier, Michel, Marchal, Frédéric, Arvieux, Catherine, Brigand, Cécile, Meeus, Pierre, Rat, Patrick, Durand-Fontanier, Sylvaine, Mariani, Pascale, Lakkis, Zaher, Loi, Valeria, Pirro, Nicolas, Sabbagh, Charles, Texier, Matthieu, Elias, Dominique, Ducreux, M, Malka, D, Boige, V, Benhamou, E
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.09.2020 Elsevier Limited Elsevier
Témata:	5-Fluorouracil Abdomen Adolescent Adult Aged Cancer Cancer therapies Chemotherapy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Disease-Free Survival Female Fluorouracil - administration & dosage Health surveillance Hematology Hematology, Oncology, and Palliative Medicine Hemorrhage Humans Hyperthermia, Induced - methods Intravenous administration Irinotecan Leucovorin - administration & dosage Life Sciences Male Medical imaging Medical prognosis Metastases Metastasis Middle Aged Mitomycin Neoplasm Metastasis Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Neuropathy Ovaries Oxaliplatin Oxaliplatin - administration & dosage Patients Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - pathology Peritoneal Neoplasms - secondary Peritoneal Neoplasms - surgery Peritoneum Risk Factors Second-Look Surgery - methods Surgery Surgical outcomes Survival Tumors Young Adult France
ISSN:	1470-2045, 1474-5488, 1474-5488
On-line přístup:	Získat plný text
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