Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics

•Proteomics linked 123 proteins to AD pathology and cognitive performance•Proteins involved in glucose metabolism are altered in cognitive impairment•Frail individuals show pathway dysregulation in absence of AD pathology Alzheimer's disease (AD) is defined by the presence of abundant amyloid-β...

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Bibliographic Details
Published in:	Neurobiology of aging Vol. 105; no. C; pp. 99 - 114
Main Authors:	Carlyle, Becky C., Kandigian, Savannah E., Kreuzer, Johannes, Das, Sudeshna, Trombetta, Bianca A., Kuo, Yikai, Bennett, David A., Schneider, Julie A., Petyuk, Vladislav A., Kitchen, Robert R., Morris, Robert, Nairn, Angus C., Hyman, Bradley T., Haas, Wilhelm, Arnold, Steven E.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.09.2021 Elsevier
Subjects:	60 APPLIED LIFE SCIENCES Aged Aged, 80 and over Aging Aging - pathology Aging - psychology Alzheimer Disease - diagnosis Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer Disease - psychology Alzheimer's disease Angular gyrus Chromatography, Liquid Cognition Cognition - physiology Cognitive resilience Female Geriatrics & Gerontology Glycolysis Humans Independent Living Male Mass Spectrometry Neuroproteomics Neurosciences & Neurology Parietal Lobe - metabolism Phosphorylation Proteasome Endopeptidase Complex - metabolism Proteomics - methods Serotonin - metabolism Synapses - metabolism Synapses - pathology FDG-PET LC-MS3 Neuroproteomics AD Angular gyrus SPS-MS3 GSEA SPE Cognition ROSMAP MS1, MS2, MS3 Aβ MMSE Cognitive resilience Aging TMT11 m/z BA39 bRPLC Alzheimer's disease AGC HPLC
ISSN:	0197-4580, 1558-1497, 1558-1497
Online Access:	Get full text
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