Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics

•Proteomics linked 123 proteins to AD pathology and cognitive performance•Proteins involved in glucose metabolism are altered in cognitive impairment•Frail individuals show pathway dysregulation in absence of AD pathology Alzheimer's disease (AD) is defined by the presence of abundant amyloid-β...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Neurobiology of aging Ročník 105; číslo C; s. 99 - 114
Hlavní autoři: Carlyle, Becky C., Kandigian, Savannah E., Kreuzer, Johannes, Das, Sudeshna, Trombetta, Bianca A., Kuo, Yikai, Bennett, David A., Schneider, Julie A., Petyuk, Vladislav A., Kitchen, Robert R., Morris, Robert, Nairn, Angus C., Hyman, Bradley T., Haas, Wilhelm, Arnold, Steven E.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.09.2021
Elsevier
Témata:
60 APPLIED LIFE SCIENCES
Aged
Aged, 80 and over
Aging
Aging - pathology
Aging - psychology
Alzheimer Disease - diagnosis
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Alzheimer Disease - psychology
Alzheimer's disease
Angular gyrus
Chromatography, Liquid
Cognition
Cognition - physiology
Cognitive resilience
Female
Geriatrics & Gerontology
Glycolysis
Humans
Independent Living
Male
Mass Spectrometry
Neuroproteomics
Neurosciences & Neurology
Parietal Lobe - metabolism
Phosphorylation
Proteasome Endopeptidase Complex - metabolism
Proteomics - methods
Serotonin - metabolism
Synapses - metabolism
Synapses - pathology
FDG-PET
LC-MS3
Neuroproteomics
AD
Angular gyrus
SPS-MS3
GSEA
SPE
Cognition
ROSMAP
MS1, MS2, MS3
Aβ
MMSE
Cognitive resilience
Aging
TMT11
m/z
BA39
bRPLC
Alzheimer's disease
AGC
HPLC
ISSN:0197-4580, 1558-1497, 1558-1497
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract •Proteomics linked 123 proteins to AD pathology and cognitive performance•Proteins involved in glucose metabolism are altered in cognitive impairment•Frail individuals show pathway dysregulation in absence of AD pathology Alzheimer's disease (AD) is defined by the presence of abundant amyloid-β (Aβ) and tau neuropathology. While this neuropathology is necessary for AD diagnosis, it is not sufficient for causing cognitive impairment. Up to one third of community dwelling older adults harbor intermediate to high levels of AD neuropathology at death yet demonstrate no significant cognitive impairment. Conversely, there are individuals who exhibit dementia with no gross explanatory neuropathology. In prior studies, synapse loss correlated with cognitive impairment. To understand how synaptic composition changes in relation to neuropathology and cognition, multiplexed liquid chromatography mass-spectrometry was used to quantify enriched synaptic proteins from the parietal association cortex of 100 subjects with contrasting levels of AD pathology and cognitive performance. 123 unique proteins were significantly associated with diagnostic category. Functional analysis showed enrichment of serotonin release and oxidative phosphorylation categories in normal (cognitively unimpaired, low neuropathology) and "resilient" (unimpaired despite AD pathology) individuals. In contrast, frail individuals, (low pathology, impaired cognition) showed a metabolic shift towards glycolysis and increased presence of proteasome subunits.
AbstractList •Proteomics linked 123 proteins to AD pathology and cognitive performance•Proteins involved in glucose metabolism are altered in cognitive impairment•Frail individuals show pathway dysregulation in absence of AD pathology Alzheimer's disease (AD) is defined by the presence of abundant amyloid-β (Aβ) and tau neuropathology. While this neuropathology is necessary for AD diagnosis, it is not sufficient for causing cognitive impairment. Up to one third of community dwelling older adults harbor intermediate to high levels of AD neuropathology at death yet demonstrate no significant cognitive impairment. Conversely, there are individuals who exhibit dementia with no gross explanatory neuropathology. In prior studies, synapse loss correlated with cognitive impairment. To understand how synaptic composition changes in relation to neuropathology and cognition, multiplexed liquid chromatography mass-spectrometry was used to quantify enriched synaptic proteins from the parietal association cortex of 100 subjects with contrasting levels of AD pathology and cognitive performance. 123 unique proteins were significantly associated with diagnostic category. Functional analysis showed enrichment of serotonin release and oxidative phosphorylation categories in normal (cognitively unimpaired, low neuropathology) and "resilient" (unimpaired despite AD pathology) individuals. In contrast, frail individuals, (low pathology, impaired cognition) showed a metabolic shift towards glycolysis and increased presence of proteasome subunits.
Alzheimer's disease (AD) is defined by the presence of abundant amyloid-β (Aβ) and tau neuropathology. While this neuropathology is necessary for AD diagnosis, it is not sufficient for causing cognitive impairment. Up to one third of community dwelling older adults harbor intermediate to high levels of AD neuropathology at death yet demonstrate no significant cognitive impairment. Conversely, there are individuals who exhibit dementia with no gross explanatory neuropathology. In prior studies, synapse loss correlated with cognitive impairment. To understand how synaptic composition changes in relation to neuropathology and cognition, multiplexed liquid chromatography mass-spectrometry was used to quantify enriched synaptic proteins from the parietal association cortex of 100 subjects with contrasting levels of AD pathology and cognitive performance. 123 unique proteins were significantly associated with diagnostic category. Functional analysis showed enrichment of serotonin release and oxidative phosphorylation categories in normal (cognitively unimpaired, low neuropathology) and "resilient" (unimpaired despite AD pathology) individuals. In contrast, frail individuals, (low pathology, impaired cognition) showed a metabolic shift towards glycolysis and increased presence of proteasome subunits.Alzheimer's disease (AD) is defined by the presence of abundant amyloid-β (Aβ) and tau neuropathology. While this neuropathology is necessary for AD diagnosis, it is not sufficient for causing cognitive impairment. Up to one third of community dwelling older adults harbor intermediate to high levels of AD neuropathology at death yet demonstrate no significant cognitive impairment. Conversely, there are individuals who exhibit dementia with no gross explanatory neuropathology. In prior studies, synapse loss correlated with cognitive impairment. To understand how synaptic composition changes in relation to neuropathology and cognition, multiplexed liquid chromatography mass-spectrometry was used to quantify enriched synaptic proteins from the parietal association cortex of 100 subjects with contrasting levels of AD pathology and cognitive performance. 123 unique proteins were significantly associated with diagnostic category. Functional analysis showed enrichment of serotonin release and oxidative phosphorylation categories in normal (cognitively unimpaired, low neuropathology) and "resilient" (unimpaired despite AD pathology) individuals. In contrast, frail individuals, (low pathology, impaired cognition) showed a metabolic shift towards glycolysis and increased presence of proteasome subunits.
Alzheimer's disease (AD) is defined by the presence of abundant amyloid-β (Aβ) and tau neuropathology. While this neuropathology is necessary for AD diagnosis, it is not sufficient for causing cognitive impairment. Up to one third of community dwelling older adults harbor intermediate to high levels of AD neuropathology at death yet demonstrate no significant cognitive impairment. Conversely, there are individuals who exhibit dementia with no gross explanatory neuropathology. In prior studies, synapse loss correlated with cognitive impairment. To understand how synaptic composition changes in relation to neuropathology and cognition, multiplexed liquid chromatography mass-spectrometry was used to quantify enriched synaptic proteins from the parietal association cortex of 100 subjects with contrasting levels of AD pathology and cognitive performance. 123 unique proteins were significantly associated with diagnostic category. Functional analysis showed enrichment of serotonin release and oxidative phosphorylation categories in normal (cognitively unimpaired, low neuropathology) and "resilient" (unimpaired despite AD pathology) individuals. In contrast, frail individuals, (low pathology, impaired cognition) showed a metabolic shift towards glycolysis and increased presence of proteasome subunits.
Author Schneider, Julie A.
Bennett, David A.
Nairn, Angus C.
Morris, Robert
Arnold, Steven E.
Kandigian, Savannah E.
Kreuzer, Johannes
Petyuk, Vladislav A.
Trombetta, Bianca A.
Kuo, Yikai
Haas, Wilhelm
Carlyle, Becky C.
Kitchen, Robert R.
Das, Sudeshna
Hyman, Bradley T.
AuthorAffiliation c Massachusetts General Hospital Cancer Center, Charlestown, MA, USA
d Massachusetts General Hospital, Cardiology Division, Charlestown, MA, USA
a Massachusetts General Hospital Department of Neurology, Charlestown, MA, USA
e Rush Alzheimer’s Disease Center, Chicago, IL, USA
b Harvard Medical School, Boston, MA, USA
g Yale Department of Psychiatry, New Haven, CT, USA
f Pacific Northwest National Laboratory, Richland, WA, USA
AuthorAffiliation_xml – name: a Massachusetts General Hospital Department of Neurology, Charlestown, MA, USA
– name: d Massachusetts General Hospital, Cardiology Division, Charlestown, MA, USA
– name: f Pacific Northwest National Laboratory, Richland, WA, USA
– name: b Harvard Medical School, Boston, MA, USA
– name: c Massachusetts General Hospital Cancer Center, Charlestown, MA, USA
– name: e Rush Alzheimer’s Disease Center, Chicago, IL, USA
– name: g Yale Department of Psychiatry, New Haven, CT, USA
Author_xml – sequence: 1
  givenname: Becky C.
  orcidid: 0000-0003-1491-3217
  surname: Carlyle
  fullname: Carlyle, Becky C.
  email: bcarlyle@mgh.harvard.edu
  organization: Massachusetts General Hospital Department of Neurology, Charlestown, MA, USA
– sequence: 2
  givenname: Savannah E.
  surname: Kandigian
  fullname: Kandigian, Savannah E.
  organization: Massachusetts General Hospital Department of Neurology, Charlestown, MA, USA
– sequence: 3
  givenname: Johannes
  surname: Kreuzer
  fullname: Kreuzer, Johannes
  organization: Harvard Medical School, Boston, MA, USA
– sequence: 4
  givenname: Sudeshna
  orcidid: 0000-0002-9486-6811
  surname: Das
  fullname: Das, Sudeshna
  organization: Massachusetts General Hospital Department of Neurology, Charlestown, MA, USA
– sequence: 5
  givenname: Bianca A.
  orcidid: 0000-0001-7501-0666
  surname: Trombetta
  fullname: Trombetta, Bianca A.
  organization: Massachusetts General Hospital Department of Neurology, Charlestown, MA, USA
– sequence: 6
  givenname: Yikai
  orcidid: 0000-0003-3826-7563
  surname: Kuo
  fullname: Kuo, Yikai
  organization: Massachusetts General Hospital Department of Neurology, Charlestown, MA, USA
– sequence: 7
  givenname: David A.
  surname: Bennett
  fullname: Bennett, David A.
  organization: Rush Alzheimer's Disease Center, Chicago, IL, USA
– sequence: 8
  givenname: Julie A.
  surname: Schneider
  fullname: Schneider, Julie A.
  organization: Rush Alzheimer's Disease Center, Chicago, IL, USA
– sequence: 9
  givenname: Vladislav A.
  orcidid: 0000-0003-4076-151X
  surname: Petyuk
  fullname: Petyuk, Vladislav A.
  organization: Pacific Northwest National Laboratory, Richland, WA, USA
– sequence: 10
  givenname: Robert R.
  orcidid: 0000-0003-1443-8559
  surname: Kitchen
  fullname: Kitchen, Robert R.
  organization: Harvard Medical School, Boston, MA, USA
– sequence: 11
  givenname: Robert
  surname: Morris
  fullname: Morris, Robert
  organization: Harvard Medical School, Boston, MA, USA
– sequence: 12
  givenname: Angus C.
  orcidid: 0000-0002-7075-0195
  surname: Nairn
  fullname: Nairn, Angus C.
  organization: Yale Department of Psychiatry, New Haven, CT, USA
– sequence: 13
  givenname: Bradley T.
  surname: Hyman
  fullname: Hyman, Bradley T.
  organization: Massachusetts General Hospital Department of Neurology, Charlestown, MA, USA
– sequence: 14
  givenname: Wilhelm
  surname: Haas
  fullname: Haas, Wilhelm
  organization: Harvard Medical School, Boston, MA, USA
– sequence: 15
  givenname: Steven E.
  surname: Arnold
  fullname: Arnold, Steven E.
  organization: Massachusetts General Hospital Department of Neurology, Charlestown, MA, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34052751$$D View this record in MEDLINE/PubMed
https://www.osti.gov/servlets/purl/2471545$$D View this record in Osti.gov
BookMark eNqNks9uEzEQxleoiKaFV0AW4sAlwd5_9koIqbQUkCpxAM6W1zubTPDai-0N5BX61DhJi2hPOVmWv_l9M57vLDuxzkKWvWZ0wSir364XFibvWnRGLdEuFznN2YKWC8ryJ9mMVZWYs7LhJ9mMsobPy0rQ0-wshDWllJe8fpadFiWtcl6xWXb7bWvVGFGT0bsIaANRITiNKkJHfmNcEe2WFiNugIzge-cHZTUQZTuyb2RUceWMW24JWuJMB56spqQJxMMGlEmYdkuGyUQcDfxJ194rHdHZvcXe1g2ow_Psaa9MgBd353n24_rj98vP85uvn75cXtzMdSWKOBcFbSnTnajrXBSM9S0v2r7RAILzrqG64UL0TNFG5VrUFLjo8lqDEDxvBXTFefb-wB2ndoBOg41eGTl6HJTfSqdQPnyxuJJLt5GiKJIFT4BXB4ALEWXQGEGvtLMWdJR5yVlVVkn05s7Fu18ThCgHDBqMURbcFGReFRWjNS1Zkr78v6F_ndxvKQk-HATauxA89DJ5qt0Xpv7QSEblLhpyLR9GQ-6iIWkpUzQS5N0jyL3PkeXXh3JIq9kg-N3gkJLQod_N3Tk8FnT1CKQNWtTK_ITt8Zi_Cxb8eA
CitedBy_id crossref_primary_10_1007_s00401_024_02819_6
crossref_primary_10_1186_s13024_023_00634_3
crossref_primary_10_1186_s40478_022_01455_z
crossref_primary_10_1002_advs_202400545
crossref_primary_10_1186_s40478_022_01356_1
crossref_primary_10_1186_s13024_024_00719_7
crossref_primary_10_1186_s13195_025_01733_7
crossref_primary_10_1093_pnasnexus_pgad101
crossref_primary_10_1016_j_semcdb_2022_05_028
crossref_primary_10_1016_j_expneurol_2023_114590
crossref_primary_10_1021_jasms_2c00341
crossref_primary_10_1186_s13073_024_01404_6
crossref_primary_10_1016_j_arr_2025_102699
crossref_primary_10_1016_j_phrs_2021_105805
crossref_primary_10_4103_1673_5374_373681
crossref_primary_10_1038_s41586_023_06686_1
crossref_primary_10_3390_ijms231810867
crossref_primary_10_1016_j_gene_2023_148013
crossref_primary_10_1080_14789450_2024_2313073
crossref_primary_10_1016_j_jbc_2025_110729
crossref_primary_10_3390_ijms252111720
crossref_primary_10_1111_ejn_70142
crossref_primary_10_3389_fninf_2024_1443865
crossref_primary_10_1002_prca_202200112
crossref_primary_10_1186_s40478_024_01760_9
crossref_primary_10_1186_s13024_025_00874_5
crossref_primary_10_1002_alz_12562
crossref_primary_10_1016_j_neuroscience_2024_11_020
crossref_primary_10_3389_fncel_2023_1284394
crossref_primary_10_1038_s41598_024_61157_5
crossref_primary_10_1007_s00401_024_02775_1
crossref_primary_10_1016_j_tins_2022_02_005
crossref_primary_10_3233_JAD_231034
crossref_primary_10_1016_j_arr_2022_101592
crossref_primary_10_1038_s41467_023_40208_x
crossref_primary_10_1038_s41598_024_57104_z
Cites_doi 10.1093/nar/gky1055
10.1016/j.nbd.2017.05.007
10.1038/nn.2719
10.1186/1750-1326-6-63
10.3390/proteomes6030032
10.1159/000096129
10.1038/75556
10.1038/s41598-017-05588-3
10.1073/pnas.0501823102
10.1007/s40336-014-0094-7
10.1016/j.neulet.2019.134403
10.1093/bioinformatics/bts040
10.1007/s13311-019-00755-y
10.2174/156720512801322609
10.1073/pnas.1322360111
10.1038/ncomms9992
10.1038/s41467-019-09613-z
10.1016/0003-2697(84)90782-6
10.3389/fnagi.2017.00320
10.1038/s41593-017-0011-2
10.1038/tp.2016.224
10.1002/jnr.23864
10.1001/jama.287.6.742
10.1038/nbt.3955
10.1038/s41420-017-0003-8
10.1523/JNEUROSCI.3389-17.2018
10.1038/nmeth.1714
10.1021/ac502040v
10.3758/BF03211324
10.1186/1423-0127-21-28
10.1126/science.aal3321
10.1038/s41467-020-17405-z
10.1111/ggi.12093
10.1089/ars.2016.6802
10.1007/BF00308809
10.1186/s13024-018-0282-4
10.1038/nrneurol.2017.185
10.1016/j.celrep.2017.08.063
10.1016/j.neuron.2019.12.015
10.1016/j.cell.2010.12.001
10.3233/JAD-2009-1179
10.1038/s41598-017-11690-3
10.1016/j.conb.2009.06.001
10.1093/nar/gkv350
10.1212/01.wnl.0000219668.47116.e6
10.2174/156720512801322618
10.1139/bcb-2019-0219
10.1074/jbc.M110.158477
10.3892/mmr.2015.4271
10.1038/s41598-017-14420-x
10.1056/NEJMoa0806142
10.1002/ana.410300410
10.1038/s41467-018-03509-0
10.1016/j.neurobiolaging.2012.03.004
10.1016/1044-0305(94)80016-2
10.1093/cercor/1.1.103
10.1007/s00401-019-01971-8
10.3233/JAD-179939
10.1002/ana.410270502
10.1212/01.wnl.0000271090.28148.24
10.1016/j.tins.2010.03.001
10.1016/S1474-4422(15)70016-5
10.1155/2016/6427537
10.1016/j.cell.2006.03.022
10.1186/s13072-018-0211-3
10.1038/nmeth1019
10.1001/jama.286.17.2120
10.1002/ana.25049
10.1007/978-1-4939-3341-9_1
10.1093/jmcb/mjt051
10.1212/WNL.0b013e3181b01077
10.1021/ac301572t
10.1016/j.biopsych.2015.04.005
10.1080/13825580490511125
10.1002/pmic.201300520
10.1093/brain/awq258
10.1038/s41591-020-0815-6
10.3233/JAD-132483
10.1073/pnas.0506580102
10.3233/JAD-150829
10.1016/j.jalz.2018.02.001
10.1038/nn.4594
10.1007/s00281-017-0662-9
ContentType Journal Article
Copyright 2021
Copyright © 2021. Published by Elsevier Inc.
Copyright_xml – notice: 2021
– notice: Copyright © 2021. Published by Elsevier Inc.
CorporateAuthor Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
CorporateAuthor_xml – name: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
DBID 6I.
AAFTH
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
OIOZB
OTOTI
5PM
DOI 10.1016/j.neurobiolaging.2021.04.012
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
OSTI.GOV - Hybrid
OSTI.GOV
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1558-1497
EndPage 114
ExternalDocumentID PMC8338777
2471545
34052751
10_1016_j_neurobiolaging_2021_04_012
S0197458021001275
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIA NIH HHS
  grantid: P30 AG062421
– fundername: NIA NIH HHS
  grantid: P50 AG047270
– fundername: NIA NIH HHS
  grantid: R01 AG039478
– fundername: NIA NIH HHS
  grantid: R01 AG015819
– fundername: NIA NIH HHS
  grantid: U01 AG061356
– fundername: NIA NIH HHS
  grantid: R01 AG062306
– fundername: NIA NIH HHS
  grantid: R01 AG017917
– fundername: NIA NIH HHS
  grantid: P30 AG066508
GroupedDBID ---
--K
--M
-~X
.1-
.FO
.GJ
.~1
0R~
123
1B1
1P~
1RT
1~.
1~5
29N
4.4
457
4G.
53G
5RE
5VS
7-5
71M
8P~
9JM
9JO
AABNK
AADFP
AAEDT
AAEDW
AAGJA
AAGUQ
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AATTM
AAXKI
AAXLA
AAXUO
AAYWO
ABBQC
ABCQJ
ABFNM
ABFRF
ABGSF
ABIVO
ABJNI
ABLJU
ABMAC
ABMZM
ABOYX
ABUDA
ABWVN
ABXDB
ACDAQ
ACGFO
ACGFS
ACIEU
ACIUM
ACLOT
ACRLP
ACRPL
ACVFH
ACXNI
ADBBV
ADCNI
ADEZE
ADMUD
ADNMO
ADUVX
AEBSH
AEFWE
AEHWI
AEIPS
AEKER
AENEX
AEUPX
AEVXI
AFJKZ
AFPUW
AFRHN
AFTJW
AFXIZ
AGHFR
AGQPQ
AGRDE
AGUBO
AGWIK
AGYEJ
AHHHB
AIEXJ
AIGII
AIIUN
AIKHN
AITUG
AJRQY
AJUYK
AKBMS
AKRLJ
AKRWK
AKYEP
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ANKPU
ANZVX
APXCP
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
BNPGV
CS3
DU5
EBS
EFJIC
EFKBS
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HDW
HMK
HMO
HMQ
HVGLF
HZ~
IHE
J1W
KOM
LX8
M29
M2V
M41
MO0
MOBAO
MVM
N9A
O-L
O9-
OAUVE
OD~
OKEIE
OO0
OZT
P-8
P-9
P2P
PC.
Q38
R2-
ROL
RPZ
SAE
SCC
SDF
SDG
SDP
SEL
SES
SEW
SNS
SPCBC
SSB
SSH
SSN
SSU
SSY
SSZ
T5K
WUQ
Z5R
ZGI
~G-
~HD
6I.
AACTN
AADPK
AAFTH
AAIAV
ABLVK
ABYKQ
AFCTW
AFKWA
AFYLN
AJBFU
AJOXV
AMFUW
DOVZS
LCYCR
RIG
9DU
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
OIOZB
OTOTI
5PM
ID FETCH-LOGICAL-c583t-830b01cd86628311fb73bf9cee877d90c9788f1a09a2c860e78d26ce8872b8ed3
ISICitedReferencesCount 44
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000680064700010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0197-4580
1558-1497
IngestDate Tue Sep 30 16:59:37 EDT 2025
Mon Nov 04 02:34:40 EST 2024
Sun Sep 28 07:37:28 EDT 2025
Thu Apr 03 07:10:15 EDT 2025
Tue Nov 18 21:20:57 EST 2025
Sat Nov 29 07:19:25 EST 2025
Fri Feb 23 02:44:00 EST 2024
Tue Oct 14 19:30:37 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue C
Keywords FDG-PET
LC-MS3
Neuroproteomics
AD
Angular gyrus
SPS-MS3
GSEA
SPE
Cognition
ROSMAP
MS1, MS2, MS3
Aβ
MMSE
Cognitive resilience
Aging
TMT11
m/z
BA39
bRPLC
Alzheimer's disease
AGC
HPLC
Language English
License This is an open access article under the CC BY-NC-ND license.
Copyright © 2021. Published by Elsevier Inc.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c583t-830b01cd86628311fb73bf9cee877d90c9788f1a09a2c860e78d26ce8872b8ed3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
USDOE
AC05-76RL01830
Becky C. Carlyle: Conceptualization, Methodology, Formal analysis, Investigation, Data curation, Writing – original draft, Visualization. Savannah E. Kandigian: Investigation, Writing – review & editing. Johannes Kreuzer: Investigation. Sudeshna Das: Supervision. Bianca A. Trombetta: Validation, Writing – review & editing. Yikai Kuo: Formal analysis, Visualization, Data curation. David A. Bennett: Resources, Writing – review & editing, Conceptualization. Julie A. Schneider: Resources, Conceptualization. Vladislav A. Petyuk: Writing – review & editing, Supervision. Robert R. Kitchen: Formal analysis, Data curation, Supervision, Resources. Robert Morris: Data curation. Angus C. Nairn: Writing – review & editing, Supervision. Bradley T. Hyman: Writing – review & editing, Supervision, Resources. Wilhelm Haas: Resources, Data curation, Writing – review & editing, Funding acquisition. Steven E. Arnold: Conceptualization, Resources, Data curation, Writing – review & editing, Funding acquisition.
CRediT authorship contribution statement
ORCID 0000-0003-1443-8559
0000-0002-7075-0195
0000-0003-1491-3217
0000-0001-7501-0666
0000-0003-4076-151X
0000-0002-9486-6811
0000-0003-3826-7563
0000000175010666
0000000270750195
0000000294866811
0000000314438559
000000034076151X
0000000338267563
0000000314913217
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC8338777
PMID 34052751
PQID 2535106041
PQPubID 23479
PageCount 16
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8338777
osti_scitechconnect_2471545
proquest_miscellaneous_2535106041
pubmed_primary_34052751
crossref_citationtrail_10_1016_j_neurobiolaging_2021_04_012
crossref_primary_10_1016_j_neurobiolaging_2021_04_012
elsevier_sciencedirect_doi_10_1016_j_neurobiolaging_2021_04_012
elsevier_clinicalkey_doi_10_1016_j_neurobiolaging_2021_04_012
PublicationCentury 2000
PublicationDate 2021-09-01
PublicationDateYYYYMMDD 2021-09-01
PublicationDate_xml – month: 09
  year: 2021
  text: 2021-09-01
  day: 01
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Neurobiology of aging
PublicationTitleAlternate Neurobiol Aging
PublicationYear 2021
Publisher Elsevier Inc
Elsevier
Publisher_xml – name: Elsevier Inc
– name: Elsevier
References Ferreira, Ferreira Santos-Galduróz, Ferri, Fernandes Galduróz (bib0033) 2014; 14
Elias, Gygi (bib0031) 2007; 4
O'Brien, Resnick, Zonderman, Ferrucci, Crain, Pletnikova, Rudow, Iacono, Riudavets, Driscoll, Price, Martin, Troncoso (bib0062) 2009; 18
Silverman, Chen, Czernin, Kowell, Gambhir, Phelps, Lu, Aburto, M.A.K., C.Y., G.W., J.L., W., S.I., P., G.E., M.B., P., W.J., J.M., K.A., A., C.M., E., M.J., R. (bib0073) 2001
Terry, Masliah, Salmon, Butters, DeTeresa, Hill, Hansen, Katzman (bib0079) 1991; 30
Herlitz, Nilsson, Bäckman (bib0041) 1997; 25
Mdawar, Ghossoub, Khoury (bib0059) 2020
Mizuno, Giese (bib0060) 2010
Bayés, Collins, Galtrey, Simonnet, Roy, Croning, Gou, van de Lagemaat, Milward, Whittle, Smith, Choudhary, Grant (bib0010) 2014; 88
Saharan, Mandal (bib0069) 2014
Schneider, Arvanitakis, Bang, Bennett (bib0071) 2007; 69
McAlister, Huttlin, Haas, Ting, Jedrychowski, Rogers, Kuhn, Pike, Grothe, Blethrow, Gygi (bib0057) 2012; 84
Thibaudeau, Anderson, Smith (bib0081) 2018
Johnson, Dammer, Duong, Yin, Thambisetty, Troncoso, Lah, Levey, Seyfried (bib0048) 2018; 13
Andriuta, Moullart, Schraen, Devendeville, Meyer (bib0003) 2016
Eng, McCormack, Yates (bib0032) 1994; 5
Liu, Wang, Marcora, Zhang, Goate (bib0054) 2019
Sonntag, Ryu, Amirault, Healy, Siegel, McPhie, Forester, Cohen (bib0077) 2017
Leshchyns'Ka, Sytnyk (bib0052) 2016
Ping, Duong, Yin, Gearing, Lah, Levey, Seyfried (bib0065) 2018; 5
Chen, Townsend, Goldberg, Davies, Conejero-Goldberg (bib0024) 2010
Inestrosa, Varela-Nallar (bib0045) 2014
Bossers, Wirz, Meerhoff, Essing, van Dongen, Houba, Kruse, Verhaagen, Swaab (bib0018) 2010; 133
Ando, Uemura, Kuzuya, Maesako, Asada-Utsugi, Kubota, Aoyagi, Yoshioka, Okawa, Inoue, Kawamata, Shimohama, Arai, Takahashi, Kinoshita (bib0002) 2011
Ashburner, Ball, Blake, Botstein, Butler, Cherry, Davis, Dolinski, Dwight, Eppig, Harris, Hill, Issel-Tarver, Kasarskis, Lewis, Matese, Richardson, Ringwald, Rubin, Sherlock (bib0007) 2000; 25
Wilson, Mendes De Leon, Barnes, Schneider, Bienias, Evans, Bennett (bib0089) 2002; 287
Edwards, Haas (bib0030) 2016; 1394
Mandal, Saharan, Tripathi, Murari (bib0055) 2015
Morgan (bib0061) 2018
Braak, Braak (bib0019) 1991; 82
Koffie, Hyman, Spires-Jones (bib0049) 2011; 6
Pandya, Koopmans, Slotman, Paliukhovich, Houtsmuller, Smit, Li (bib0063) 2017; 7
Arnold, Arvanitakis, Macauley-Rambach, Koenig, Wang, Ahima, Craft, Gandy, Buettner, Stoeckel, Holtzman, Nathan (bib0004) 2018; 14
Ryu, Zimmer, Rosa-Neto, Yoon (bib0068) 2019
Smedley, Haider, Durinck, Pandini, Provero, Allen, Arnaiz, Awedh, Baldock, Barbiera, Bardou, Beck, Blake, Bonierbale, Brookes, Bucci, Buetti, Burge, Cabau, Carlson, Chelala, Chrysostomou, Cittaro, Collin, Cordova, Cutts, Dassi, Genova, Djari, Esposito, Estrella, Eyras, Fernandez-Banet, Forbes, Free, Fujisawa, Gadaleta, Garcia-Manteiga, Goodstein, Gray, Guerra-Assunção, Haggarty, Han, Han, Harris, Harshbarger, Hastings, Hayes, Hoede, Hu, Hu, Hutchins, Kan, Kawaji, Keliet, Kerhornou, Kim, Kinsella, Klopp, Kong, Lawson, Lazarevic, Lee, Letellier, Li, Lio, Liu, Luo, Maass, Mariette, Maurel, Merella, Mohamed, Moreews, Nabihoudine, Ndegwa, Noirot, Perez-Llamas, Primig, Quattrone, Quesneville, Rambaldi, Reecy, Riba, Rosanoff, Saddiq, Salas, Sallou, Shepherd, Simon, Sperling, Spooner, Staines, Steinbach, Stone, Stupka, Teague, Ullah, A.Z., J., D., M., K., A., S.-J. (bib0075) 2015; 43
Itzhak, Davies, Tyanova, Mishra, Williamson, Antrobus, Cox, Weekes, Borner (bib0046) 2017; 20
Huttlin, Jedrychowski, Elias, Goswami, Rad, Beausoleil, Villén, Haas, Sowa, Gygi (bib0043) 2010; 143
Koss, Frick (bib0050) 2017; 95
Boros, Greathouse, Gentry, Curtis, Birchall, Gearing, Herskowitz (bib0017) 2017; 82
Pasterkamp, Giger (bib0064) 2009
Au, Seshadri, Knox, Beiser, Himali, Cabral, Auerbach, Green, Wolf, McKee (bib0008) 2012; 9
Bennett, Schneider, Arvanitakis, Kelly, Aggarwal, Shah, Wilson (bib0015) 2006; 66
Pirooznia, Wang, Avramopoulos, Valle, Thomas, Huganir, Goes, Potash, Zandi (bib0066) 2012; 28
Carlyle, Nairn, Wang, Yang, Jin, Simen, Ramos, Bordner, Craft, Davies, Pletikos, Šestan, Arnsten, Paspalas (bib0022) 2014; 111
DeKosky, Scheff (bib0026) 1990; 27
Gelber, Launer, White (bib0037) 2012; 9
Savva, Wharton, Ince, Forster, Matthews, Brayne (bib0070) 2009; 360
Carlyle, Nairn, Wang, Yang, Jin, Simen, Ramos, Bordner, Craft, Davies, Pletikos, Šestan, Arnsten, Paspalas (bib0023) 2014; 111
Beckmann, Lin, Wang, Cohain, Charney, Wang, Ma, Wang, Jiang, Audrain, Comella, Fakira, Hariharan, Belbin, Girdhar, Levey, Seyfried, Dammer, Duong, Lah, Haure-Mirande, Shackleton, Fanutza, Blitzer, Kenny, Zhu, Haroutunian, Katsel, Gandy, Tu, Ehrlich, Zhang, Salton, Schadt (bib0012) 2020
Delaidelli, Jan, Herms, Sorensen (bib0027) 2019
Grau, Baldi, Bussani, Tian, Stefanescu, Przybylski, Richards, Jones, Shridhar, Clausen, Ehrmann (bib0038) 2005
Bonet-Costa, Pomatto, Davies (bib0016) 2016
Distler, Schmeisser, Pelosi, Reim, Kuharev, Weiczner, Baumgart, Boeckers, Nitsch, Vogt, Tenzer (bib0029) 2014; 14
(bib0080) 2019; 47
Arnold, Hyman, Flory, Damasio, Van Hoesen (bib0005) 1991
Hu, Lin, Chen (bib0042) 2015
McAlister, Nusinow, Jedrychowski, Wühr, Huttlin, Erickson, Rad, Haas, Gygi (bib0058) 2014; 86
Subramanian, Tamayo, Mootha, Mukherjee, Ebert, Gillette, Paulovich, Pomeroy, Golub, Lander, Mesirov (bib0078) 2005; 102
Arnold, Louneva, Cao, Wang, Han, Wolk, Negash, Leurgans, Schneider, Buchman, Wilson, Bennett (bib0006) 2013; 34
Carlyle, Trombetta, Arnold (bib0020) 2018; 6
Carlyle, Kitchen, Kanyo, Voss, Pletikos, Sousa, Lam, Gerstein, Sestan, Nairn (bib0021) 2017; 20
Iacono, Markesbery, Gross, Pletnikova, Rudow, Zandi, Troncoso (bib0044) 2009; 73
Wingo, Dammer, Breen, Logsdon, Duong, Troncosco, Thambisetty, Beach, Serrano, Reiman, Caselli, Lah, Seyfried, Levey, Wingo (bib0090) 2019; 10
Wessel, Flügge (bib0086) 1984; 138
(bib0001) 2018; 14
Smith, Barrett, Joo, Nassery, Savonenko, Sodums, Marano, Munro, Brandt, Kraut, Zhou, Wong, Workman (bib0076) 2017
Ting, Rad, Gygi, Haas (bib0083) 2011; 8
Heneka, Carson, Khoury, Landreth, Brosseron, Feinstein, Jacobs, Wyss-Coray, Vitorica, Ransohoff, Herrup, Frautschy, Finsen, Brown, Verkhratsky, Yamanaka, Koistinaho, Latz, Halle, Petzold, Town, Morgan, Shinohara, Perry, Holmes, Bazan, Brooks, Hunot, Joseph, Deigendesch, Garaschuk, Boddeke, Dinarello, Breitner, Cole, Golenbock, Kummer (bib0040) 2015
Quintremil, Ferrer, F., J., M. (bib0067) 2019
Dias, Gandra, Brenzikofer, Macedo (bib0028) 2020; 98
Matthes, Hettich, Schilling, Flores-Dominguez, Blank, Wiglenda, Buntru, Wolf, Weber, Vorberg, Dagane, Dittmar, Wanker, Ehninger, Krauss (bib0056) 2018
Bai, Wang, Li, Chen, Yu, Dey, Yarbro, Han, Lutz, Rao, Jiao, Sifford, Han, Wang, Tan, Shaw, Cho, Zhou, Wang, Niu, Mancieri, Messler, Sun, Wu, Pagala, High, Bi, Zhang, Chi, Haroutunian, Zhang, Beach, Yu, Peng (bib0009) 2020; 105
Li, Zhang, Yang, Howrigan, Wilkinson, Souaiaia, Evgrafov, Genovese, Clementel, Tudor, Abel, Knowles, Neale, Wang, Sun, Coba (bib0053) 2017; 20
Bennett, Schneider, Aggarwal, Arvanitakis, Shah, Kelly, Fox, Cochran, Arends, Treinkman, Wilson (bib0014) 2006; 27
Shirai, Saito (bib0072) 2014
Simandi, Pajer, Karolyi, Sieler, Jiang, Kolostyak, Sari, Fekecs, Pap, Patsalos, Contreras, Reho, Papp, Guo, Horvath, Kiss, Keresztessy, Vámosi, Hickman, Xu, Dormann, Hortobagyi, Antal, Nógrádi, Nagy (bib0074) 2018
Wilkinson, Li, Coba (bib0087) 2017
Foster, de Hoog, Zhang, Zhang, Xie, Mootha, Mann (bib0035) 2006; 125
Johnson, Dammer, Duong, Ping, Zhou, Yin, Higginbotham, Guajardo, White, Troncoso, Thambisetty, Montine, Lee, Trojanowski, Beach, Reiman, Haroutunian, Wang, Schadt, Zhang, Dickson, Ertekin-Taner, Golde, Petyuk, De Jager, Bennett, Wingo, Rangaraju, Hajjar, Shulman, Lah, Levey, Seyfried (bib0047) 2020; 26
Vlassenko, Raichle (bib0085) 2015; 3
Föcking, Dicker, Lopez, Hryniewiecka, Wynne, English, Cagney, Cotter (bib0034) 2016; 6
Gasparoni, Bultmann, Lutsik, Kraus, Sordon, Vlcek, Dietinger, Steinmaurer, Haider, Mulholland, Arzberger, Roeber, Riemenschneider, Kretzschmar, Giese, Leonhardt, Walter (bib0036) 2018
Wilson, Bienias, Evans, Bennett (bib0088) 2004; 11
Lapek, Greninger, Morris, Amzallag, Pruteanu-Malinici, Benes, Haas (bib0051) 2017; 35
Bayés, van de Lagemaat, Collins, Croning, Whittle, Choudhary, Grant (bib0011) 2011; 14
Ting, Rad, Gygi, Haas (bib0084) 2011; 8
Christoforou, Mulvey, Breckels, Geladaki, Hurrell, Hayward, Naake, Gatto, Viner, Arias, Lilley (bib0025) 2016; 7
Guglielmotto, Monteleone, Vasciaveo, Repetto, Manassero, Tabaton, Tamagno (bib0039) 2017
Bennett, Buchman, Boyle, Barnes, Wilson, Schneider (bib0013) 2018; 64
Thul, Åkesson, Wiking, Mahdessian, Geladaki, Ait Blal, Alm, Asplund, Björk, Breckels, Bäckström, Danielsson, Fagerberg, Fall, Gatto, Gnann, Hober, Hjelmare, Johansson, Lee, Lindskog, Mulder, Mulvey, Nilsson, Oksvold, Rockberg, Schutten, Schwenk, Sivertsson, Sjöstedt, Skogs, Stadler, Sullivan, Tegel, Winsnes, Zhang, Zwahlen, Mardinoglu, Pontén, von Feilitzen, Lilley, Uhlén, Lundberg (bib0082) 2017; 356
Christoforou (10.1016/j.neurobiolaging.2021.04.012_bib0025) 2016; 7
Koss (10.1016/j.neurobiolaging.2021.04.012_bib0050) 2017; 95
Vlassenko (10.1016/j.neurobiolaging.2021.04.012_bib0085) 2015; 3
Leshchyns'Ka (10.1016/j.neurobiolaging.2021.04.012_bib0052) 2016
Eng (10.1016/j.neurobiolaging.2021.04.012_bib0032) 1994; 5
Matthes (10.1016/j.neurobiolaging.2021.04.012_bib0056) 2018
Bossers (10.1016/j.neurobiolaging.2021.04.012_bib0018) 2010; 133
Grau (10.1016/j.neurobiolaging.2021.04.012_bib0038) 2005
Gelber (10.1016/j.neurobiolaging.2021.04.012_bib0037) 2012; 9
Arnold (10.1016/j.neurobiolaging.2021.04.012_bib0006) 2013; 34
Ashburner (10.1016/j.neurobiolaging.2021.04.012_bib0007) 2000; 25
Carlyle (10.1016/j.neurobiolaging.2021.04.012_bib0021) 2017; 20
Elias (10.1016/j.neurobiolaging.2021.04.012_bib0031) 2007; 4
Huttlin (10.1016/j.neurobiolaging.2021.04.012_bib0043) 2010; 143
Chen (10.1016/j.neurobiolaging.2021.04.012_bib0024) 2010
Ferreira (10.1016/j.neurobiolaging.2021.04.012_bib0033) 2014; 14
Ryu (10.1016/j.neurobiolaging.2021.04.012_bib0068) 2019
Edwards (10.1016/j.neurobiolaging.2021.04.012_bib0030) 2016; 1394
Inestrosa (10.1016/j.neurobiolaging.2021.04.012_bib0045) 2014
Hu (10.1016/j.neurobiolaging.2021.04.012_bib0042) 2015
Koffie (10.1016/j.neurobiolaging.2021.04.012_bib0049) 2011; 6
Au (10.1016/j.neurobiolaging.2021.04.012_bib0008) 2012; 9
Dias (10.1016/j.neurobiolaging.2021.04.012_bib0028) 2020; 98
Simandi (10.1016/j.neurobiolaging.2021.04.012_bib0074) 2018
Pasterkamp (10.1016/j.neurobiolaging.2021.04.012_bib0064) 2009
McAlister (10.1016/j.neurobiolaging.2021.04.012_bib0058) 2014; 86
Morgan (10.1016/j.neurobiolaging.2021.04.012_bib0061) 2018
Bonet-Costa (10.1016/j.neurobiolaging.2021.04.012_bib0016) 2016
O'Brien (10.1016/j.neurobiolaging.2021.04.012_bib0062) 2009; 18
Mdawar (10.1016/j.neurobiolaging.2021.04.012_bib0059) 2020
Smedley (10.1016/j.neurobiolaging.2021.04.012_bib0075) 2015; 43
Liu (10.1016/j.neurobiolaging.2021.04.012_bib0054) 2019
Quintremil (10.1016/j.neurobiolaging.2021.04.012_bib0067) 2019
Mandal (10.1016/j.neurobiolaging.2021.04.012_bib0055) 2015
Ping (10.1016/j.neurobiolaging.2021.04.012_bib0065) 2018; 5
Terry (10.1016/j.neurobiolaging.2021.04.012_bib0079) 1991; 30
Arnold (10.1016/j.neurobiolaging.2021.04.012_bib0005) 1991
Heneka (10.1016/j.neurobiolaging.2021.04.012_bib0040) 2015
Herlitz (10.1016/j.neurobiolaging.2021.04.012_bib0041) 1997; 25
(10.1016/j.neurobiolaging.2021.04.012_bib0001) 2018; 14
Pandya (10.1016/j.neurobiolaging.2021.04.012_bib0063) 2017; 7
Silverman (10.1016/j.neurobiolaging.2021.04.012_bib0073) 2001
Wingo (10.1016/j.neurobiolaging.2021.04.012_bib0090) 2019; 10
Braak (10.1016/j.neurobiolaging.2021.04.012_bib0019) 1991; 82
Li (10.1016/j.neurobiolaging.2021.04.012_bib0053) 2017; 20
Shirai (10.1016/j.neurobiolaging.2021.04.012_bib0072) 2014
Johnson (10.1016/j.neurobiolaging.2021.04.012_bib0048) 2018; 13
Beckmann (10.1016/j.neurobiolaging.2021.04.012_bib0012) 2020
Bennett (10.1016/j.neurobiolaging.2021.04.012_bib0013) 2018; 64
Saharan (10.1016/j.neurobiolaging.2021.04.012_bib0069) 2014
Thibaudeau (10.1016/j.neurobiolaging.2021.04.012_bib0081) 2018
Gasparoni (10.1016/j.neurobiolaging.2021.04.012_bib0036) 2018
Thul (10.1016/j.neurobiolaging.2021.04.012_bib0082) 2017; 356
DeKosky (10.1016/j.neurobiolaging.2021.04.012_bib0026) 1990; 27
Savva (10.1016/j.neurobiolaging.2021.04.012_bib0070) 2009; 360
Ting (10.1016/j.neurobiolaging.2021.04.012_bib0083) 2011; 8
Carlyle (10.1016/j.neurobiolaging.2021.04.012_bib0023) 2014; 111
Wilson (10.1016/j.neurobiolaging.2021.04.012_bib0089) 2002; 287
Ando (10.1016/j.neurobiolaging.2021.04.012_bib0002) 2011
Lapek (10.1016/j.neurobiolaging.2021.04.012_bib0051) 2017; 35
Foster (10.1016/j.neurobiolaging.2021.04.012_bib0035) 2006; 125
Johnson (10.1016/j.neurobiolaging.2021.04.012_bib0047) 2020; 26
Wilkinson (10.1016/j.neurobiolaging.2021.04.012_bib0087) 2017
Guglielmotto (10.1016/j.neurobiolaging.2021.04.012_bib0039) 2017
Wilson (10.1016/j.neurobiolaging.2021.04.012_bib0088) 2004; 11
Andriuta (10.1016/j.neurobiolaging.2021.04.012_bib0003) 2016
Bayés (10.1016/j.neurobiolaging.2021.04.012_bib0011) 2011; 14
Iacono (10.1016/j.neurobiolaging.2021.04.012_bib0044) 2009; 73
Bai (10.1016/j.neurobiolaging.2021.04.012_bib0009) 2020; 105
Arnold (10.1016/j.neurobiolaging.2021.04.012_bib0004) 2018; 14
Boros (10.1016/j.neurobiolaging.2021.04.012_bib0017) 2017; 82
Bennett (10.1016/j.neurobiolaging.2021.04.012_bib0015) 2006; 66
Ting (10.1016/j.neurobiolaging.2021.04.012_bib0084) 2011; 8
McAlister (10.1016/j.neurobiolaging.2021.04.012_bib0057) 2012; 84
Mizuno (10.1016/j.neurobiolaging.2021.04.012_bib0060) 2010
Pirooznia (10.1016/j.neurobiolaging.2021.04.012_bib0066) 2012; 28
Wessel (10.1016/j.neurobiolaging.2021.04.012_bib0086) 1984; 138
Smith (10.1016/j.neurobiolaging.2021.04.012_bib0076) 2017
Schneider (10.1016/j.neurobiolaging.2021.04.012_bib0071) 2007; 69
Subramanian (10.1016/j.neurobiolaging.2021.04.012_bib0078) 2005; 102
Bennett (10.1016/j.neurobiolaging.2021.04.012_bib0014) 2006; 27
(10.1016/j.neurobiolaging.2021.04.012_bib0080) 2019; 47
Sonntag (10.1016/j.neurobiolaging.2021.04.012_bib0077) 2017
Distler (10.1016/j.neurobiolaging.2021.04.012_bib0029) 2014; 14
Bayés (10.1016/j.neurobiolaging.2021.04.012_bib0010) 2014; 88
Itzhak (10.1016/j.neurobiolaging.2021.04.012_bib0046) 2017; 20
Delaidelli (10.1016/j.neurobiolaging.2021.04.012_bib0027) 2019
Föcking (10.1016/j.neurobiolaging.2021.04.012_bib0034) 2016; 6
Carlyle (10.1016/j.neurobiolaging.2021.04.012_bib0020) 2018; 6
Carlyle (10.1016/j.neurobiolaging.2021.04.012_bib0022) 2014; 111
References_xml – year: 2020
  ident: bib0012
  article-title: Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease
  publication-title: Nat. Commun.
– volume: 14
  start-page: 2607
  year: 2014
  end-page: 2613
  ident: bib0029
  article-title: In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics
  publication-title: Proteomics
– year: 2018
  ident: bib0074
  article-title: Arginine methyltransferase PRMT8 provides cellular stress tolerance in aging motoneurons
  publication-title: J. Neurosci.
– volume: 356
  start-page: eaal3321
  year: 2017
  ident: bib0082
  article-title: A subcellular map of the human proteome
  publication-title: Science.
– volume: 138
  start-page: 141
  year: 1984
  end-page: 143
  ident: bib0086
  article-title: A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids
  publication-title: Anal. Biochem.
– volume: 34
  start-page: 157
  year: 2013
  end-page: 168
  ident: bib0006
  article-title: Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease
  publication-title: Neurobiol. Aging
– volume: 35
  start-page: 983
  year: 2017
  end-page: 989
  ident: bib0051
  article-title: Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities
  publication-title: Nat. Biotechnol.
– volume: 30
  start-page: 572
  year: 1991
  end-page: 580
  ident: bib0079
  article-title: Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
  publication-title: Ann. Neurol.
– volume: 7
  start-page: 12107
  year: 2017
  ident: bib0063
  article-title: Correlation profiling of brain sub-cellular proteomes reveals co-assembly of synaptic proteins and subcellular distribution
  publication-title: Sci. Rep.
– volume: 43
  start-page: W589
  year: 2015
  end-page: W598
  ident: bib0075
  article-title: The BioMart community portal: an innovative alternative to large, centralized data repositories
  publication-title: Nucleic Acids Res
– volume: 14
  start-page: 23
  year: 2014
  end-page: 31
  ident: bib0033
  article-title: Rate of cognitive decline in relation to sex after 60 years-of-age: a systematic review
  publication-title: Geriatr. Gerontol. Int.
– volume: 105
  start-page: 975
  year: 2020
  end-page: 991
  ident: bib0009
  article-title: Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression
  publication-title: Neuron.
– volume: 6
  start-page: e959
  year: 2016
  ident: bib0034
  article-title: Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder
  publication-title: Transl. Psychiatry.
– volume: 102
  start-page: 15545
  year: 2005
  end-page: 15550
  ident: bib0078
  article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 3
  start-page: 27
  year: 2015
  ident: bib0085
  article-title: Brain aerobic glycolysis functions and Alzheimer's disease
  publication-title: Clin. Transl. imaging
– volume: 360
  start-page: 2302
  year: 2009
  end-page: 2309
  ident: bib0070
  article-title: Age, Neuropathology, and Dementia
  publication-title: N. Engl. J. Med.
– year: 2005
  ident: bib0038
  article-title: Implications of the serine protease HtrA1 in amyloid precursor protein processing
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 73
  start-page: 665
  year: 2009
  end-page: 673
  ident: bib0044
  article-title: The Nun study: clinically silent AD, neuronal hypertrophy, and linguistic skills in early life
  publication-title: Neurology.
– year: 2016
  ident: bib0016
  article-title: The proteasome and oxidative stress in Alzheimer's disease
  publication-title: Antioxid. Redox. Signal
– year: 2018
  ident: bib0061
  article-title: Complement in the pathogenesis of Alzheimer's disease
  publication-title: Semin. Immunopathol.
– volume: 69
  start-page: 2197
  year: 2007
  end-page: 2204
  ident: bib0071
  article-title: Mixed brain pathologies account for most dementia cases in community-dwelling older persons
  publication-title: Neurology.
– year: 1991
  ident: bib0005
  article-title: The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with alzheimer's disease
  publication-title: Cereb. Cortex.
– volume: 14
  start-page: 19
  year: 2011
  end-page: 21
  ident: bib0011
  article-title: Characterization of the proteome, diseases and evolution of the human postsynaptic density
  publication-title: Nat. Neurosci.
– year: 2018
  ident: bib0036
  article-title: DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex
  publication-title: Epigenetics Chromatin
– volume: 95
  start-page: 539
  year: 2017
  end-page: 562
  ident: bib0050
  article-title: Sex differences in hippocampal function
  publication-title: J. Neurosci. Res.
– volume: 14
  start-page: 367
  year: 2018
  end-page: 429
  ident: bib0001
  article-title: 2018 Alzheimer's disease facts and figures
  publication-title: Alzheimer's Dement
– volume: 13
  start-page: 52
  year: 2018
  ident: bib0048
  article-title: Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
  publication-title: Mol. Neurodegener.
– volume: 1394
  start-page: 1
  year: 2016
  end-page: 13
  ident: bib0030
  article-title: Multiplexed quantitative proteomics for high-throughput comprehensive proteome comparisons of human cell lines
  publication-title: Methods. Mol. Biol.
– year: 2017
  ident: bib0076
  article-title: Molecular imaging of serotonin degeneration in mild cognitive impairment
  publication-title: Neurobiol. Dis.
– year: 2010
  ident: bib0024
  article-title: MAPT isoforms: Differential transcriptional profiles related to 3R and 4R splice variants
  publication-title: J. Alzheimer's Dis.
– year: 2016
  ident: bib0003
  article-title: What are the most frequently impaired markers of neurodegeneration in ADNI subjects?
  publication-title: J. Alzheimer's Dis.
– year: 2014
  ident: bib0072
  article-title: Diacylglycerol kinase as a possible therapeutic target for neuronal diseases
  publication-title: J. Biomed. Sci.
– volume: 11
  start-page: 280
  year: 2004
  end-page: 303
  ident: bib0088
  article-title: Religious orders study: Overview and change in cognitive and motor speed
  publication-title: Aging. Neuropsychol. Cogn.
– volume: 27
  start-page: 457
  year: 1990
  end-page: 464
  ident: bib0026
  article-title: Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
  publication-title: Ann. Neurol.
– volume: 4
  start-page: 207
  year: 2007
  end-page: 214
  ident: bib0031
  article-title: Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
  publication-title: Nat. Methods
– year: 2015
  ident: bib0042
  article-title: Integrated analysis of differential gene expression profiles in hippocampi to identify candidate genes involved in Alzheimer's disease
  publication-title: Mol. Med. Rep.
– year: 2019
  ident: bib0054
  article-title: Promoter DNA hypermethylation – Implications for Alzheimer's disease
  publication-title: Neurosci. Lett.
– volume: 88
  year: 2014
  ident: bib0010
  article-title: Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes
  publication-title: Mol. Brain
– volume: 64
  start-page: S161
  year: 2018
  end-page: S189
  ident: bib0013
  article-title: Religious orders study and rush memory and aging project
  publication-title: J. Alzheimers. Dis.
– year: 2014
  ident: bib0069
  article-title: The emerging role of glutathione in alzheimer's disease
  publication-title: J. Alzheimer's Dis.
– year: 2015
  ident: bib0055
  article-title: Brain Glutathione levels - A novel biomarker for mild cognitive impairment and Alzheimer's disease
  publication-title: Biol. Psychiatry.
– volume: 14
  start-page: 168
  year: 2018
  end-page: 181
  ident: bib0004
  article-title: Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
  publication-title: Nat. Rev. Neurol.
– year: 2014
  ident: bib0045
  article-title: Wnt signaling in the nervous system and in Alzheimer's disease
  publication-title: J. Mol. Cell Biol.
– year: 2017
  ident: bib0087
  article-title: Synaptic GAP and GEF complexes cluster proteins essential for GTP signaling
  publication-title: Sci. Rep.
– volume: 111
  start-page: 5036
  year: 2014
  end-page: 5041
  ident: bib0023
  article-title: cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 18
  start-page: 665
  year: 2009
  end-page: 675
  ident: bib0062
  article-title: Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA)
  publication-title: J. Alzheimers. Dis.
– volume: 66
  start-page: 1837
  year: 2006
  end-page: 1844
  ident: bib0015
  article-title: Neuropathology of older persons without cognitive impairment from two community-based studies
  publication-title: Neurology
– year: 2019
  ident: bib0068
  article-title: Consequences of metabolic disruption in Alzheimer's disease pathology
  publication-title: Neurotherapeutics
– year: 2018
  ident: bib0081
  article-title: A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
  publication-title: Nat. Commun.
– year: 2019
  ident: bib0027
  article-title: Translational control in brain pathologies: biological significance and therapeutic opportunities
  publication-title: Acta Neuropathol
– year: 2017
  ident: bib0077
  article-title: Late-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles
  publication-title: Sci. Rep.
– volume: 20
  start-page: 1150
  year: 2017
  end-page: 1161
  ident: bib0053
  article-title: Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders
  publication-title: Nat. Neurosci.
– volume: 82
  start-page: 602
  year: 2017
  end-page: 614
  ident: bib0017
  article-title: Dendritic spines provide cognitive resilience against Alzheimer's disease
  publication-title: Ann. Neurol.
– volume: 125
  start-page: 187
  year: 2006
  end-page: 199
  ident: bib0035
  article-title: A Mammalian Organelle Map by Protein Correlation Profiling
  publication-title: Cell.
– volume: 8
  start-page: 937
  year: 2011
  end-page: 940
  ident: bib0084
  article-title: MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics
  publication-title: Nat. Methods
– volume: 20
  start-page: 2706
  year: 2017
  end-page: 2718
  ident: bib0046
  article-title: A mass spectrometry-based approach for mapping protein subcellular localization reveals the spatial proteome of mouse primary neurons
  publication-title: Cell. Rep
– volume: 26
  start-page: 769
  year: 2020
  end-page: 780
  ident: bib0047
  article-title: Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
  publication-title: Nat. Med.
– year: 2017
  ident: bib0039
  article-title: The decrease of Uch-L1 activity is a common mechanism responsible for Aβ 42 accumulation in Alzheimer's and vascular disease
  publication-title: Front. Aging. Neurosci.
– volume: 9
  start-page: 664
  year: 2012
  end-page: 672
  ident: bib0037
  article-title: The Honolulu-Asia Aging Study: epidemiologic and neuropathologic research on cognitive impairment
  publication-title: Curr. Alzheimer Res.
– year: 2011
  ident: bib0002
  article-title: N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: Implications for neurodegeneration in Alzheimer disease
  publication-title: J. Biol. Chem.
– year: 2010
  ident: bib0060
  article-title: Towards a molecular understanding of sex differences in memory formation
  publication-title: Trends. Neurosci
– volume: 7
  start-page: 9992
  year: 2016
  ident: bib0025
  article-title: A draft map of the mouse pluripotent stem cell spatial proteome
  publication-title: Nat. Commun.
– volume: 5
  year: 2018
  ident: bib0065
  article-title: Global quantitative analysis of the human brain proteome in Alzheimer's and Parkinson's
  publication-title: Disease. Sci. Data
– volume: 111
  year: 2014
  ident: bib0022
  article-title: CAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex
  publication-title: Proc. Natl. Acad. Sci. USA.
– volume: 287
  start-page: 742
  year: 2002
  end-page: 748
  ident: bib0089
  article-title: Participation in cognitively stimulating activities and risk of incident Alzheimer disease
  publication-title: JAMA.
– volume: 28
  start-page: 897
  year: 2012
  end-page: 899
  ident: bib0066
  article-title: SynaptomeDB: an ontology-based knowledgebase for synaptic genes
  publication-title: Bioinformatics.
– year: 2020
  ident: bib0059
  article-title: Selective serotonin reuptake inhibitors and Alzheimer's disease
  publication-title: Neural. Regen. Res.
– volume: 9
  start-page: 673
  year: 2012
  end-page: 686
  ident: bib0008
  article-title: The Framingham Brain Donation Program: neuropathology along the cognitive continuum
  publication-title: Curr. Alzheimer Res.
– year: 2018
  ident: bib0056
  article-title: Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis
  publication-title: Cell. Death. Discov
– volume: 5
  start-page: 976
  year: 1994
  end-page: 989
  ident: bib0032
  article-title: An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
  publication-title: J. Am. Soc. Mass Spectrom.
– volume: 47
  start-page: D330
  year: 2019
  end-page: D338
  ident: bib0080
  article-title: The Gene Ontology Resource: 20 years and still GOing strong
  publication-title: Nucleic. Acids. Res
– volume: 27
  start-page: 169
  year: 2006
  end-page: 176
  ident: bib0014
  article-title: Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study
  publication-title: Neuroepidemiology
– volume: 6
  start-page: 63
  year: 2011
  ident: bib0049
  article-title: Alzheimer's disease: synapses gone cold
  publication-title: Mol. Neurodegener.
– year: 2009
  ident: bib0064
  article-title: Semaphorin function in neural plasticity and disease
  publication-title: Curr. Opin. Neurobiol.
– volume: 10
  start-page: 1619
  year: 2019
  ident: bib0090
  article-title: Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age
  publication-title: Nat. Commun.
– volume: 25
  start-page: 801
  year: 1997
  end-page: 811
  ident: bib0041
  article-title: Gender differences in episodic memory
  publication-title: Mem. Cogn.
– year: 2016
  ident: bib0052
  article-title: Synaptic cell adhesion molecules in Alzheimer's disease
  publication-title: Neural. Plast
– volume: 84
  start-page: 7469
  year: 2012
  end-page: 7478
  ident: bib0057
  article-title: Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses
  publication-title: Anal. Chem.
– volume: 8
  start-page: 937
  year: 2011
  end-page: 940
  ident: bib0083
  article-title: MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics
  publication-title: Nat. Methods
– volume: 6
  start-page: 32
  year: 2018
  ident: bib0020
  article-title: Proteomic Approaches for the Discovery of Biofluid Biomarkers of Neurodegenerative Dementias
  publication-title: Proteomes.
– volume: 98
  start-page: 293
  year: 2020
  end-page: 298
  ident: bib0028
  article-title: Subcellular fractionation of frozen skeletal muscle samples
  publication-title: Biochem. Cell. Biol.
– volume: 25
  start-page: 25
  year: 2000
  end-page: 29
  ident: bib0007
  article-title: Gene Ontology: tool for the unification of biology
  publication-title: Nat. Genet.
– volume: 20
  start-page: 1787
  year: 2017
  end-page: 1795
  ident: bib0021
  article-title: A multiregional proteomic survey of the postnatal human brain
  publication-title: Nat. Neurosci.
– year: 2015
  ident: bib0040
  article-title: Neuroinflammation in Alzheimer's disease
  publication-title: Lancet Neurol
– volume: 133
  start-page: 3699
  year: 2010
  end-page: 3723
  ident: bib0018
  article-title: Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease
  publication-title: Brain.
– volume: 143
  start-page: 1174
  year: 2010
  end-page: 1189
  ident: bib0043
  article-title: A tissue-specific atlas of mouse protein phosphorylation and expression
  publication-title: Cell.
– year: 2001
  ident: bib0073
  article-title: Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome
  publication-title: J. Am. Med. Assoc.
– volume: 82
  start-page: 239
  year: 1991
  end-page: 259
  ident: bib0019
  article-title: Neuropathological stageing of Alzheimer-related changes
  publication-title: Acta. Neuropathol
– volume: 86
  start-page: 7150
  year: 2014
  end-page: 7158
  ident: bib0058
  article-title: MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes
  publication-title: Anal. Chem.
– year: 2019
  ident: bib0067
  article-title: Roles of semaphorins in neurodegenerative diseases
  publication-title: Neurons - Dendrites and Axons
– volume: 47
  start-page: D330
  year: 2019
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0080
  article-title: The Gene Ontology Resource: 20 years and still GOing strong
  publication-title: Nucleic. Acids. Res
  doi: 10.1093/nar/gky1055
– year: 2017
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0076
  article-title: Molecular imaging of serotonin degeneration in mild cognitive impairment
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2017.05.007
– volume: 14
  start-page: 19
  year: 2011
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0011
  article-title: Characterization of the proteome, diseases and evolution of the human postsynaptic density
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2719
– volume: 6
  start-page: 63
  year: 2011
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0049
  article-title: Alzheimer's disease: synapses gone cold
  publication-title: Mol. Neurodegener.
  doi: 10.1186/1750-1326-6-63
– volume: 6
  start-page: 32
  year: 2018
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0020
  article-title: Proteomic Approaches for the Discovery of Biofluid Biomarkers of Neurodegenerative Dementias
  publication-title: Proteomes.
  doi: 10.3390/proteomes6030032
– volume: 27
  start-page: 169
  year: 2006
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0014
  article-title: Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study
  publication-title: Neuroepidemiology
  doi: 10.1159/000096129
– volume: 25
  start-page: 25
  year: 2000
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0007
  article-title: Gene Ontology: tool for the unification of biology
  publication-title: Nat. Genet.
  doi: 10.1038/75556
– year: 2017
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0087
  article-title: Synaptic GAP and GEF complexes cluster proteins essential for GTP signaling
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-05588-3
– year: 2005
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0038
  article-title: Implications of the serine protease HtrA1 in amyloid precursor protein processing
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0501823102
– volume: 3
  start-page: 27
  year: 2015
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0085
  article-title: Brain aerobic glycolysis functions and Alzheimer's disease
  publication-title: Clin. Transl. imaging
  doi: 10.1007/s40336-014-0094-7
– year: 2019
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0054
  article-title: Promoter DNA hypermethylation – Implications for Alzheimer's disease
  publication-title: Neurosci. Lett.
  doi: 10.1016/j.neulet.2019.134403
– volume: 28
  start-page: 897
  year: 2012
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0066
  article-title: SynaptomeDB: an ontology-based knowledgebase for synaptic genes
  publication-title: Bioinformatics.
  doi: 10.1093/bioinformatics/bts040
– year: 2019
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0068
  article-title: Consequences of metabolic disruption in Alzheimer's disease pathology
  publication-title: Neurotherapeutics
  doi: 10.1007/s13311-019-00755-y
– volume: 9
  start-page: 673
  year: 2012
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0008
  article-title: The Framingham Brain Donation Program: neuropathology along the cognitive continuum
  publication-title: Curr. Alzheimer Res.
  doi: 10.2174/156720512801322609
– volume: 111
  start-page: 5036
  year: 2014
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0023
  article-title: cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1322360111
– volume: 7
  start-page: 9992
  year: 2016
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0025
  article-title: A draft map of the mouse pluripotent stem cell spatial proteome
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms9992
– volume: 10
  start-page: 1619
  year: 2019
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0090
  article-title: Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09613-z
– volume: 138
  start-page: 141
  year: 1984
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0086
  article-title: A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids
  publication-title: Anal. Biochem.
  doi: 10.1016/0003-2697(84)90782-6
– year: 2017
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0039
  article-title: The decrease of Uch-L1 activity is a common mechanism responsible for Aβ 42 accumulation in Alzheimer's and vascular disease
  publication-title: Front. Aging. Neurosci.
  doi: 10.3389/fnagi.2017.00320
– volume: 5
  year: 2018
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0065
  article-title: Global quantitative analysis of the human brain proteome in Alzheimer's and Parkinson's
  publication-title: Disease. Sci. Data
– volume: 20
  start-page: 1787
  year: 2017
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0021
  article-title: A multiregional proteomic survey of the postnatal human brain
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-017-0011-2
– volume: 6
  start-page: e959
  year: 2016
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0034
  article-title: Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder
  publication-title: Transl. Psychiatry.
  doi: 10.1038/tp.2016.224
– volume: 95
  start-page: 539
  year: 2017
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0050
  article-title: Sex differences in hippocampal function
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.23864
– volume: 287
  start-page: 742
  year: 2002
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0089
  article-title: Participation in cognitively stimulating activities and risk of incident Alzheimer disease
  publication-title: JAMA.
  doi: 10.1001/jama.287.6.742
– volume: 111
  year: 2014
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0022
  article-title: CAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex
  publication-title: Proc. Natl. Acad. Sci. USA.
  doi: 10.1073/pnas.1322360111
– volume: 35
  start-page: 983
  year: 2017
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0051
  article-title: Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3955
– year: 2018
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0056
  article-title: Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis
  publication-title: Cell. Death. Discov
  doi: 10.1038/s41420-017-0003-8
– year: 2019
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0067
  article-title: Roles of semaphorins in neurodegenerative diseases
– year: 2018
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0074
  article-title: Arginine methyltransferase PRMT8 provides cellular stress tolerance in aging motoneurons
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3389-17.2018
– volume: 8
  start-page: 937
  year: 2011
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0084
  article-title: MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1714
– volume: 86
  start-page: 7150
  year: 2014
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0058
  article-title: MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes
  publication-title: Anal. Chem.
  doi: 10.1021/ac502040v
– volume: 25
  start-page: 801
  year: 1997
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0041
  article-title: Gender differences in episodic memory
  publication-title: Mem. Cogn.
  doi: 10.3758/BF03211324
– year: 2014
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0072
  article-title: Diacylglycerol kinase as a possible therapeutic target for neuronal diseases
  publication-title: J. Biomed. Sci.
  doi: 10.1186/1423-0127-21-28
– volume: 356
  start-page: eaal3321
  issue: 80-.
  year: 2017
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0082
  article-title: A subcellular map of the human proteome
  publication-title: Science.
  doi: 10.1126/science.aal3321
– year: 2020
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0012
  article-title: Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-17405-z
– volume: 14
  start-page: 23
  year: 2014
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0033
  article-title: Rate of cognitive decline in relation to sex after 60 years-of-age: a systematic review
  publication-title: Geriatr. Gerontol. Int.
  doi: 10.1111/ggi.12093
– year: 2016
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0016
  article-title: The proteasome and oxidative stress in Alzheimer's disease
  publication-title: Antioxid. Redox. Signal
  doi: 10.1089/ars.2016.6802
– year: 2020
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0059
  article-title: Selective serotonin reuptake inhibitors and Alzheimer's disease
  publication-title: Neural. Regen. Res.
– volume: 82
  start-page: 239
  year: 1991
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0019
  article-title: Neuropathological stageing of Alzheimer-related changes
  publication-title: Acta. Neuropathol
  doi: 10.1007/BF00308809
– volume: 13
  start-page: 52
  year: 2018
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0048
  article-title: Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
  publication-title: Mol. Neurodegener.
  doi: 10.1186/s13024-018-0282-4
– volume: 14
  start-page: 168
  year: 2018
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0004
  article-title: Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
  publication-title: Nat. Rev. Neurol.
  doi: 10.1038/nrneurol.2017.185
– volume: 20
  start-page: 2706
  year: 2017
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0046
  article-title: A mass spectrometry-based approach for mapping protein subcellular localization reveals the spatial proteome of mouse primary neurons
  publication-title: Cell. Rep
  doi: 10.1016/j.celrep.2017.08.063
– volume: 105
  start-page: 975
  year: 2020
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0009
  article-title: Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression
  publication-title: Neuron.
  doi: 10.1016/j.neuron.2019.12.015
– volume: 143
  start-page: 1174
  year: 2010
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0043
  article-title: A tissue-specific atlas of mouse protein phosphorylation and expression
  publication-title: Cell.
  doi: 10.1016/j.cell.2010.12.001
– volume: 18
  start-page: 665
  year: 2009
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0062
  article-title: Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA)
  publication-title: J. Alzheimers. Dis.
  doi: 10.3233/JAD-2009-1179
– volume: 7
  start-page: 12107
  year: 2017
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0063
  article-title: Correlation profiling of brain sub-cellular proteomes reveals co-assembly of synaptic proteins and subcellular distribution
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-11690-3
– year: 2009
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0064
  article-title: Semaphorin function in neural plasticity and disease
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2009.06.001
– volume: 43
  start-page: W589
  year: 2015
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0075
  article-title: The BioMart community portal: an innovative alternative to large, centralized data repositories
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkv350
– volume: 66
  start-page: 1837
  year: 2006
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0015
  article-title: Neuropathology of older persons without cognitive impairment from two community-based studies
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000219668.47116.e6
– volume: 9
  start-page: 664
  year: 2012
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0037
  article-title: The Honolulu-Asia Aging Study: epidemiologic and neuropathologic research on cognitive impairment
  publication-title: Curr. Alzheimer Res.
  doi: 10.2174/156720512801322618
– volume: 98
  start-page: 293
  year: 2020
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0028
  article-title: Subcellular fractionation of frozen skeletal muscle samples
  publication-title: Biochem. Cell. Biol.
  doi: 10.1139/bcb-2019-0219
– year: 2011
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0002
  article-title: N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: Implications for neurodegeneration in Alzheimer disease
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.158477
– volume: 88
  year: 2014
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0010
  article-title: Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes
  publication-title: Mol. Brain
– year: 2015
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0042
  article-title: Integrated analysis of differential gene expression profiles in hippocampi to identify candidate genes involved in Alzheimer's disease
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2015.4271
– year: 2017
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0077
  article-title: Late-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-14420-x
– volume: 360
  start-page: 2302
  year: 2009
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0070
  article-title: Age, Neuropathology, and Dementia
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0806142
– volume: 30
  start-page: 572
  year: 1991
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0079
  article-title: Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.410300410
– year: 2018
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0081
  article-title: A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03509-0
– volume: 34
  start-page: 157
  year: 2013
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0006
  article-title: Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease
  publication-title: Neurobiol. Aging
  doi: 10.1016/j.neurobiolaging.2012.03.004
– volume: 5
  start-page: 976
  year: 1994
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0032
  article-title: An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
  publication-title: J. Am. Soc. Mass Spectrom.
  doi: 10.1016/1044-0305(94)80016-2
– year: 1991
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0005
  article-title: The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with alzheimer's disease
  publication-title: Cereb. Cortex.
  doi: 10.1093/cercor/1.1.103
– year: 2019
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0027
  article-title: Translational control in brain pathologies: biological significance and therapeutic opportunities
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-019-01971-8
– volume: 64
  start-page: S161
  year: 2018
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0013
  article-title: Religious orders study and rush memory and aging project
  publication-title: J. Alzheimers. Dis.
  doi: 10.3233/JAD-179939
– volume: 27
  start-page: 457
  year: 1990
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0026
  article-title: Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.410270502
– volume: 69
  start-page: 2197
  year: 2007
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0071
  article-title: Mixed brain pathologies account for most dementia cases in community-dwelling older persons
  publication-title: Neurology.
  doi: 10.1212/01.wnl.0000271090.28148.24
– year: 2010
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0060
  article-title: Towards a molecular understanding of sex differences in memory formation
  publication-title: Trends. Neurosci
  doi: 10.1016/j.tins.2010.03.001
– year: 2015
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0040
  article-title: Neuroinflammation in Alzheimer's disease
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(15)70016-5
– year: 2016
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0052
  article-title: Synaptic cell adhesion molecules in Alzheimer's disease
  publication-title: Neural. Plast
  doi: 10.1155/2016/6427537
– volume: 125
  start-page: 187
  year: 2006
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0035
  article-title: A Mammalian Organelle Map by Protein Correlation Profiling
  publication-title: Cell.
  doi: 10.1016/j.cell.2006.03.022
– year: 2018
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0036
  article-title: DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex
  publication-title: Epigenetics Chromatin
  doi: 10.1186/s13072-018-0211-3
– volume: 4
  start-page: 207
  year: 2007
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0031
  article-title: Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
  publication-title: Nat. Methods
  doi: 10.1038/nmeth1019
– year: 2001
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0073
  article-title: Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome
  publication-title: J. Am. Med. Assoc.
  doi: 10.1001/jama.286.17.2120
– volume: 82
  start-page: 602
  year: 2017
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0017
  article-title: Dendritic spines provide cognitive resilience against Alzheimer's disease
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.25049
– volume: 1394
  start-page: 1
  year: 2016
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0030
  article-title: Multiplexed quantitative proteomics for high-throughput comprehensive proteome comparisons of human cell lines
  publication-title: Methods. Mol. Biol.
  doi: 10.1007/978-1-4939-3341-9_1
– year: 2014
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0045
  article-title: Wnt signaling in the nervous system and in Alzheimer's disease
  publication-title: J. Mol. Cell Biol.
  doi: 10.1093/jmcb/mjt051
– volume: 73
  start-page: 665
  year: 2009
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0044
  article-title: The Nun study: clinically silent AD, neuronal hypertrophy, and linguistic skills in early life
  publication-title: Neurology.
  doi: 10.1212/WNL.0b013e3181b01077
– volume: 84
  start-page: 7469
  year: 2012
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0057
  article-title: Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses
  publication-title: Anal. Chem.
  doi: 10.1021/ac301572t
– volume: 8
  start-page: 937
  year: 2011
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0083
  article-title: MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1714
– year: 2015
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0055
  article-title: Brain Glutathione levels - A novel biomarker for mild cognitive impairment and Alzheimer's disease
  publication-title: Biol. Psychiatry.
  doi: 10.1016/j.biopsych.2015.04.005
– volume: 11
  start-page: 280
  year: 2004
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0088
  article-title: Religious orders study: Overview and change in cognitive and motor speed
  publication-title: Aging. Neuropsychol. Cogn.
  doi: 10.1080/13825580490511125
– volume: 14
  start-page: 2607
  year: 2014
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0029
  article-title: In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics
  publication-title: Proteomics
  doi: 10.1002/pmic.201300520
– volume: 133
  start-page: 3699
  year: 2010
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0018
  article-title: Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease
  publication-title: Brain.
  doi: 10.1093/brain/awq258
– volume: 26
  start-page: 769
  year: 2020
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0047
  article-title: Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
  publication-title: Nat. Med.
  doi: 10.1038/s41591-020-0815-6
– year: 2014
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0069
  article-title: The emerging role of glutathione in alzheimer's disease
  publication-title: J. Alzheimer's Dis.
  doi: 10.3233/JAD-132483
– volume: 102
  start-page: 15545
  year: 2005
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0078
  article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0506580102
– year: 2016
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0003
  article-title: What are the most frequently impaired markers of neurodegeneration in ADNI subjects?
  publication-title: J. Alzheimer's Dis.
  doi: 10.3233/JAD-150829
– volume: 14
  start-page: 367
  year: 2018
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0001
  article-title: 2018 Alzheimer's disease facts and figures
  publication-title: Alzheimer's Dement
  doi: 10.1016/j.jalz.2018.02.001
– year: 2010
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0024
  article-title: MAPT isoforms: Differential transcriptional profiles related to 3R and 4R splice variants
  publication-title: J. Alzheimer's Dis.
– volume: 20
  start-page: 1150
  year: 2017
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0053
  article-title: Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4594
– year: 2018
  ident: 10.1016/j.neurobiolaging.2021.04.012_bib0061
  article-title: Complement in the pathogenesis of Alzheimer's disease
  publication-title: Semin. Immunopathol.
  doi: 10.1007/s00281-017-0662-9
SSID ssj0007476
Score 2.5333054
Snippet •Proteomics linked 123 proteins to AD pathology and cognitive performance•Proteins involved in glucose metabolism are altered in cognitive impairment•Frail...
Alzheimer's disease (AD) is defined by the presence of abundant amyloid-β (Aβ) and tau neuropathology. While this neuropathology is necessary for AD diagnosis,...
Alzheimer’s disease (AD) is defined by the presence of abundant amyloid-β (Aβ) and tau neuropathology. While this neuropathology is necessary for AD diagnosis,...
SourceID pubmedcentral
osti
proquest
pubmed
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 99
SubjectTerms 60 APPLIED LIFE SCIENCES
Aged
Aged, 80 and over
Aging
Aging - pathology
Aging - psychology
Alzheimer Disease - diagnosis
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Alzheimer Disease - psychology
Alzheimer's disease
Angular gyrus
Chromatography, Liquid
Cognition
Cognition - physiology
Cognitive resilience
Female
Geriatrics & Gerontology
Glycolysis
Humans
Independent Living
Male
Mass Spectrometry
Neuroproteomics
Neurosciences & Neurology
Parietal Lobe - metabolism
Phosphorylation
Proteasome Endopeptidase Complex - metabolism
Proteomics - methods
Serotonin - metabolism
Synapses - metabolism
Synapses - pathology
Title Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0197458021001275
https://dx.doi.org/10.1016/j.neurobiolaging.2021.04.012
https://www.ncbi.nlm.nih.gov/pubmed/34052751
https://www.proquest.com/docview/2535106041
https://www.osti.gov/servlets/purl/2471545
https://pubmed.ncbi.nlm.nih.gov/PMC8338777
Volume 105
WOSCitedRecordID wos000680064700010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVESC
  databaseName: Elsevier SD Freedom Collection Journals 2021
  customDbUrl:
  eissn: 1558-1497
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0007476
  issn: 0197-4580
  databaseCode: AIEXJ
  dateStart: 19950101
  isFulltext: true
  titleUrlDefault: https://www.sciencedirect.com
  providerName: Elsevier
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1db9MwFLW6Dk17QcD4KIPJSBNvmZI4iR0hhAoMwSZNSBtS3yLXcWhGl1b9UstP4MfwG7m24yQdVOoeeEmbpLYV3VPfY-fecxE6ztyMC8kDR7i-cAJJAyf2I-mkBLgGBcJBPK6LTdCLC9brxV9brd82F2YxpEXBlst4_F9NDdfA2Cp19g7mrjqFC_AdjA5HMDsctzL85argYyXDqiUYVAQML01QR5rbkKHxrbQBrW6pihQbZaYcuKSq4m0q-akXDAvFKzVntZGISzjNJiY9Qg-hh1W5ztMm8dUiIFbxScUefLc-U78AmQxXJq75vRQ_VvXW7bnWkc3LXVoOtL_ggzp74nwi5z8N6M5GA7hZR0R-NJlql_NUTgemRLjd3fC9KnwLnFM5I4ewzA1MEG81ZbthY9I1FZb-8gVmW-L6pLAPqJ_sRI2i1W1N-HYDEeMbDQkCHNanpQzuuha3vbWDduEjZm202_1y2jurfD_gO9pDx3UU4ebB99Ge7W4TJ2qPYJr_19LndgRvgxJdPUD3y7UM7hoMPkQtWTxCB12AwehmhV9jHV2sLX6AfllYYgtLXMMSK1jiCpa4AUsMAMDrsMR5gTUssYEltrDE_RVuwBI3YYlrWD5G3z6dXn347JR1QBwRMjJzGFG79SJlUQRk2POyPiX9LAZ6xyhNY1fElLHM427MfcEiV1KW-pGQ4D_9PpMpeYLaxaiQzxCORZgKl_I-YTRgYcBVr-CDgBKkGUxMHfTGWiIRpUi-qtUyTGw05HWybtJEmTRxgwRM2kFh1XpsxGK2bPfWGj2xCdHgwhNA8pbt31XtS-JsCPEdejhUWFOtlXa0UEF20NwH6gpLrA56ZSGYgPdRrxR5IUfzaeKHBJx65AZeBz01kKye3KK7g-gaWKsfKGX79TtFPtAK94wQpVP6fGOfh2i_ni1eoPZsMpcv0T2xmOXTyRHaoT12VP43_wBhSyN_
linkProvider Elsevier
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synaptic+proteins+associated+with+cognitive+performance+and+neuropathology+in+older+humans+revealed+by+multiplexed+fractionated+proteomics&rft.jtitle=Neurobiology+of+aging&rft.au=Carlyle%2C+Becky+C&rft.au=Kandigian%2C+Savannah+E&rft.au=Kreuzer%2C+Johannes&rft.au=Das%2C+Sudeshna&rft.date=2021-09-01&rft.eissn=1558-1497&rft.volume=105&rft.spage=99&rft_id=info:doi/10.1016%2Fj.neurobiolaging.2021.04.012&rft_id=info%3Apmid%2F34052751&rft.externalDocID=34052751
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0197-4580&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0197-4580&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0197-4580&client=summon