The potential effect of improved provision of rabies post-exposure prophylaxis in Gavi-eligible countries: a modelling study

Tens of thousands of people die from dog-mediated rabies annually. Deaths can be prevented through post-exposure prophylaxis for people who have been bitten, and the disease eliminated through dog vaccination. Current post-exposure prophylaxis use saves many lives, but availability remains poor in m...

Full description

Saved in:

Bibliographic Details
Published in:	The Lancet infectious diseases Vol. 19; no. 1; pp. 102 - 111
Main Authors:	Hampson, Katie, Ventura, Francesco, Steenson, Rachel, Mancy, Rebecca, Trotter, Caroline, Cooper, Laura, Abela-Ridder, Bernadette, Knopf, Lea, Ringenier, Moniek, Tenzin, Tenzin, Ly, Sowath, Tarantola, Arnaud, Moyengar, Ronelngar, Oussiguéré, Assandi, Bonfoh, Bassirou, Narayana, DH Ashwath, Sudarshan, Mysore Kalappa, Muturi, Matthew, Mwatondo, Athman, Wambura, Gati, Andriamandimby, Soa Fy, Baril, Laurence, Edosoa, Glenn T, Traoré, Abdallah, Jayme, Sarah, Kotzé, Johann, Gunesekera, Amila, Chitnis, Nakul, Hattendorf, Jan, Laager, Mirjam, Lechenne, Monique, Zinsstag, Jakob, Changalucha, Joel, Mtema, Zac, Lugelo, Ahmed, Lushasi, Kennedy, Yurachai, Onphirul, Metcalf, Charlotte Jessica E., Rajeev, Malavika, Blanton, Jesse, Costa, Galileu Barbosa, Sreenivasan, Nandini, Wallace, Ryan, Briggs, Deborah, Taylor, Louise, Thumbi, Samuel M., Huong, Nguyen Thi Thanh
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 01.01.2019 Elsevier Limited New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001 Elsevier Science ;, The Lancet Pub. Group
Subjects:	Animal vaccines Animals Bites and Stings - virology Child, Preschool Cost-Benefit Analysis - methods Costs Dog Diseases - prevention & control Dogs Economic analysis Economic models Endemic Diseases - prevention & control Epidemiology Exposure Fatalities Female Human health and pathology Humans Immunization Immunoglobulins Immunoglobulins - therapeutic use Incidence Infectious diseases Investment policy Life Sciences Low income groups Male Models, Economic Post-Exposure Prophylaxis - economics Post-Exposure Prophylaxis - methods Prevention Production capacity Prophylaxis Quality-Adjusted Life Years Rabies Rabies - epidemiology Rabies - mortality Rabies - prevention & control Rabies - virology Rabies Vaccines - economics Rabies Vaccines - therapeutic use Rabies virus - immunology Rabies virus - isolation & purification Risk assessment Scaling Studies Vaccination - economics Vaccines World Health Organization Cambodia Asia United States > US Africa
ISSN:	1473-3099, 1474-4457, 1474-4457
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Tens of thousands of people die from dog-mediated rabies annually. Deaths can be prevented through post-exposure prophylaxis for people who have been bitten, and the disease eliminated through dog vaccination. Current post-exposure prophylaxis use saves many lives, but availability remains poor in many rabies-endemic countries due to high costs, poor access, and supply. We developed epidemiological and economic models to investigate the effect of an investment in post-exposure prophylaxis by Gavi, the Vaccine Alliance. We modelled post-exposure prophylaxis use according to the status quo, with improved access using WHO-recommended intradermal vaccination, with and without rabies immunoglobulin, and with and without dog vaccination. We took the health provider perspective, including only direct costs. We predict more than 1 million deaths will occur in the 67 rabies-endemic countries considered from 2020 to 2035, under the status quo. Current post-exposure prophylaxis use prevents approximately 56 000 deaths annually. Expanded access to, and free provision of, post-exposure prophylaxis would prevent an additional 489 000 deaths between 2020 and 2035. Under this switch to efficient intradermal post-exposure prophylaxis regimens, total projected vaccine needs remain similar (about 73 million vials) yet 17·4 million more people are vaccinated, making this an extremely cost-effective method, with costs of US$635 per death averted and $33 per disability-adjusted life-years averted. Scaling up dog vaccination programmes could eliminate dog-mediated rabies over this time period; improved post-exposure prophylaxis access remains cost-effective under this scenario, especially in combination with patient risk assessments to reduce unnecessary post-exposure prophylaxis use. Investing in post-exposure vaccines would be an extremely cost-effective intervention that could substantially reduce disease burden and catalyse dog vaccination efforts to eliminate dog-mediated rabies. World Health Organization.
AbstractList	Summary Background Tens of thousands of people die from dog-mediated rabies annually. Deaths can be prevented through post-exposure prophylaxis for people who have been bitten, and the disease eliminated through dog vaccination. Current post-exposure prophylaxis use saves many lives, but availability remains poor in many rabies-endemic countries due to high costs, poor access, and supply. Methods We developed epidemiological and economic models to investigate the effect of an investment in post-exposure prophylaxis by Gavi, the Vaccine Alliance. We modelled post-exposure prophylaxis use according to the status quo, with improved access using WHO-recommended intradermal vaccination, with and without rabies immunoglobulin, and with and without dog vaccination. We took the health provider perspective, including only direct costs. Findings We predict more than 1 million deaths will occur in the 67 rabies-endemic countries considered from 2020 to 2035, under the status quo. Current post-exposure prophylaxis use prevents approximately 56 000 deaths annually. Expanded access to, and free provision of, post-exposure prophylaxis would prevent an additional 489 000 deaths between 2020 and 2035. Under this switch to efficient intradermal post-exposure prophylaxis regimens, total projected vaccine needs remain similar (about 73 million vials) yet 17·4 million more people are vaccinated, making this an extremely cost-effective method, with costs of US$635 per death averted and $33 per disability-adjusted life-years averted. Scaling up dog vaccination programmes could eliminate dog-mediated rabies over this time period; improved post-exposure prophylaxis access remains cost-effective under this scenario, especially in combination with patient risk assessments to reduce unnecessary post-exposure prophylaxis use. Interpretation Investing in post-exposure vaccines would be an extremely cost-effective intervention that could substantially reduce disease burden and catalyse dog vaccination efforts to eliminate dog-mediated rabies. Funding World Health Organization. Background: Tens of thousands of people die from dog-mediated rabies annually. Deaths can be prevented through post-exposure prophylaxis for people who have been bitten, and the disease eliminated through dog vaccination. Current post-exposure prophylaxis use saves many lives, but availability remains poor in many rabies-endemic countries due to high costs, poor access, and supply.Methods: We developed epidemiological and economic models to investigate the effect of an investment in post-exposure prophylaxis by Gavi, the Vaccine Alliance. We modelled post-exposure prophylaxis use according to the status quo, with improved access using WHO-recommended intradermal vaccination, with and without rabies immunoglobulin, and with and without dog vaccination. We took the health provider perspective, including only direct costs.Findings: We predict more than 1 million deaths will occur in the 67 rabies-endemic countries considered from 2020 to 2035, under the status quo. Current post-exposure prophylaxis use prevents approximately 56 000 deaths annually. Expanded access to, and free provision of, post-exposure prophylaxis would prevent an additional 489 000 deaths between 2020 and 2035. Under this switch to efficient intradermal post-exposure prophylaxis regimens, total projected vaccine needs remain similar (about 73 million vials) yet 17·4 million more people are vaccinated, making this an extremely cost-effective method, with costs of US$635 per death averted and $33 per disability-adjusted life-years averted. Scaling up dog vaccination programmes could eliminate dog-mediated rabies over this time period; improved post-exposure prophylaxis access remains cost-effective under this scenario, especially in combination with patient risk assessments to reduce unnecessary post-exposure prophylaxis use.Interpretation: Investing in post-exposure vaccines would be an extremely cost-effective intervention that could substantially reduce disease burden and catalyse dog vaccination efforts to eliminate dog-mediated rabies.Funding: World Health Organization. Tens of thousands of people die from dog-mediated rabies annually. Deaths can be prevented through post-exposure prophylaxis for people who have been bitten, and the disease eliminated through dog vaccination. Current post-exposure prophylaxis use saves many lives, but availability remains poor in many rabies-endemic countries due to high costs, poor access, and supply. We developed epidemiological and economic models to investigate the effect of an investment in post-exposure prophylaxis by Gavi, the Vaccine Alliance. We modelled post-exposure prophylaxis use according to the status quo, with improved access using WHO-recommended intradermal vaccination, with and without rabies immunoglobulin, and with and without dog vaccination. We took the health provider perspective, including only direct costs. We predict more than 1 million deaths will occur in the 67 rabies-endemic countries considered from 2020 to 2035, under the status quo. Current post-exposure prophylaxis use prevents approximately 56 000 deaths annually. Expanded access to, and free provision of, post-exposure prophylaxis would prevent an additional 489 000 deaths between 2020 and 2035. Under this switch to efficient intradermal post-exposure prophylaxis regimens, total projected vaccine needs remain similar (about 73 million vials) yet 17·4 million more people are vaccinated, making this an extremely cost-effective method, with costs of US$635 per death averted and $33 per disability-adjusted life-years averted. Scaling up dog vaccination programmes could eliminate dog-mediated rabies over this time period; improved post-exposure prophylaxis access remains cost-effective under this scenario, especially in combination with patient risk assessments to reduce unnecessary post-exposure prophylaxis use. Investing in post-exposure vaccines would be an extremely cost-effective intervention that could substantially reduce disease burden and catalyse dog vaccination efforts to eliminate dog-mediated rabies. World Health Organization. Tens of thousands of people die from dog-mediated rabies annually. Deaths can be prevented through post-exposure prophylaxis for people who have been bitten, and the disease eliminated through dog vaccination. Current post-exposure prophylaxis use saves many lives, but availability remains poor in many rabies-endemic countries due to high costs, poor access, and supply.BACKGROUNDTens of thousands of people die from dog-mediated rabies annually. Deaths can be prevented through post-exposure prophylaxis for people who have been bitten, and the disease eliminated through dog vaccination. Current post-exposure prophylaxis use saves many lives, but availability remains poor in many rabies-endemic countries due to high costs, poor access, and supply.We developed epidemiological and economic models to investigate the effect of an investment in post-exposure prophylaxis by Gavi, the Vaccine Alliance. We modelled post-exposure prophylaxis use according to the status quo, with improved access using WHO-recommended intradermal vaccination, with and without rabies immunoglobulin, and with and without dog vaccination. We took the health provider perspective, including only direct costs.METHODSWe developed epidemiological and economic models to investigate the effect of an investment in post-exposure prophylaxis by Gavi, the Vaccine Alliance. We modelled post-exposure prophylaxis use according to the status quo, with improved access using WHO-recommended intradermal vaccination, with and without rabies immunoglobulin, and with and without dog vaccination. We took the health provider perspective, including only direct costs.We predict more than 1 million deaths will occur in the 67 rabies-endemic countries considered from 2020 to 2035, under the status quo. Current post-exposure prophylaxis use prevents approximately 56 000 deaths annually. Expanded access to, and free provision of, post-exposure prophylaxis would prevent an additional 489 000 deaths between 2020 and 2035. Under this switch to efficient intradermal post-exposure prophylaxis regimens, total projected vaccine needs remain similar (about 73 million vials) yet 17·4 million more people are vaccinated, making this an extremely cost-effective method, with costs of US$635 per death averted and $33 per disability-adjusted life-years averted. Scaling up dog vaccination programmes could eliminate dog-mediated rabies over this time period; improved post-exposure prophylaxis access remains cost-effective under this scenario, especially in combination with patient risk assessments to reduce unnecessary post-exposure prophylaxis use.FINDINGSWe predict more than 1 million deaths will occur in the 67 rabies-endemic countries considered from 2020 to 2035, under the status quo. Current post-exposure prophylaxis use prevents approximately 56 000 deaths annually. Expanded access to, and free provision of, post-exposure prophylaxis would prevent an additional 489 000 deaths between 2020 and 2035. Under this switch to efficient intradermal post-exposure prophylaxis regimens, total projected vaccine needs remain similar (about 73 million vials) yet 17·4 million more people are vaccinated, making this an extremely cost-effective method, with costs of US$635 per death averted and $33 per disability-adjusted life-years averted. Scaling up dog vaccination programmes could eliminate dog-mediated rabies over this time period; improved post-exposure prophylaxis access remains cost-effective under this scenario, especially in combination with patient risk assessments to reduce unnecessary post-exposure prophylaxis use.Investing in post-exposure vaccines would be an extremely cost-effective intervention that could substantially reduce disease burden and catalyse dog vaccination efforts to eliminate dog-mediated rabies.INTERPRETATIONInvesting in post-exposure vaccines would be an extremely cost-effective intervention that could substantially reduce disease burden and catalyse dog vaccination efforts to eliminate dog-mediated rabies.World Health Organization.FUNDINGWorld Health Organization.
Author	Rajeev, Malavika Chitnis, Nakul Jayme, Sarah Traoré, Abdallah Changalucha, Joel Wallace, Ryan Moyengar, Ronelngar Costa, Galileu Barbosa Mwatondo, Athman Narayana, DH Ashwath Ly, Sowath Cooper, Laura Hampson, Katie Mtema, Zac Kotzé, Johann Yurachai, Onphirul Thumbi, Samuel M. Tarantola, Arnaud Lechenne, Monique Blanton, Jesse Muturi, Matthew Edosoa, Glenn T Laager, Mirjam Tenzin, Tenzin Sudarshan, Mysore Kalappa Oussiguéré, Assandi Knopf, Lea Lugelo, Ahmed Sreenivasan, Nandini Ringenier, Moniek Lushasi, Kennedy Bonfoh, Bassirou Mancy, Rebecca Baril, Laurence Briggs, Deborah Taylor, Louise Gunesekera, Amila Andriamandimby, Soa Fy Trotter, Caroline Huong, Nguyen Thi Thanh Ventura, Francesco Metcalf, Charlotte Jessica E. Zinsstag, Jakob Hattendorf, Jan Abela-Ridder, Bernadette Steenson, Rachel Wambura, Gati
Author_xml	– sequence: 1 givenname: Katie surname: Hampson fullname: Hampson, Katie email: katie.hampson@glasgow.ac.uk – sequence: 2 givenname: Francesco surname: Ventura fullname: Ventura, Francesco – sequence: 3 givenname: Rachel surname: Steenson fullname: Steenson, Rachel – sequence: 4 givenname: Rebecca surname: Mancy fullname: Mancy, Rebecca – sequence: 5 givenname: Caroline surname: Trotter fullname: Trotter, Caroline email: clt56@cam.ac.uk – sequence: 6 givenname: Laura surname: Cooper fullname: Cooper, Laura – sequence: 7 givenname: Bernadette surname: Abela-Ridder fullname: Abela-Ridder, Bernadette – sequence: 8 givenname: Lea surname: Knopf fullname: Knopf, Lea – sequence: 9 givenname: Moniek surname: Ringenier fullname: Ringenier, Moniek – sequence: 10 givenname: Tenzin surname: Tenzin fullname: Tenzin, Tenzin – sequence: 11 givenname: Sowath surname: Ly fullname: Ly, Sowath – sequence: 12 givenname: Arnaud surname: Tarantola fullname: Tarantola, Arnaud – sequence: 13 givenname: Ronelngar surname: Moyengar fullname: Moyengar, Ronelngar – sequence: 14 givenname: Assandi surname: Oussiguéré fullname: Oussiguéré, Assandi – sequence: 15 givenname: Bassirou surname: Bonfoh fullname: Bonfoh, Bassirou – sequence: 16 givenname: DH Ashwath surname: Narayana fullname: Narayana, DH Ashwath – sequence: 17 givenname: Mysore Kalappa surname: Sudarshan fullname: Sudarshan, Mysore Kalappa – sequence: 18 givenname: Matthew surname: Muturi fullname: Muturi, Matthew – sequence: 19 givenname: Athman surname: Mwatondo fullname: Mwatondo, Athman – sequence: 20 givenname: Gati surname: Wambura fullname: Wambura, Gati – sequence: 21 givenname: Soa Fy surname: Andriamandimby fullname: Andriamandimby, Soa Fy – sequence: 22 givenname: Laurence surname: Baril fullname: Baril, Laurence – sequence: 23 givenname: Glenn T surname: Edosoa fullname: Edosoa, Glenn T – sequence: 24 givenname: Abdallah surname: Traoré fullname: Traoré, Abdallah – sequence: 25 givenname: Sarah surname: Jayme fullname: Jayme, Sarah – sequence: 26 givenname: Johann surname: Kotzé fullname: Kotzé, Johann – sequence: 27 givenname: Amila surname: Gunesekera fullname: Gunesekera, Amila – sequence: 28 givenname: Nakul surname: Chitnis fullname: Chitnis, Nakul – sequence: 29 givenname: Jan surname: Hattendorf fullname: Hattendorf, Jan – sequence: 30 givenname: Mirjam surname: Laager fullname: Laager, Mirjam – sequence: 31 givenname: Monique surname: Lechenne fullname: Lechenne, Monique – sequence: 32 givenname: Jakob surname: Zinsstag fullname: Zinsstag, Jakob – sequence: 33 givenname: Joel surname: Changalucha fullname: Changalucha, Joel – sequence: 34 givenname: Zac surname: Mtema fullname: Mtema, Zac – sequence: 35 givenname: Ahmed surname: Lugelo fullname: Lugelo, Ahmed – sequence: 36 givenname: Kennedy surname: Lushasi fullname: Lushasi, Kennedy – sequence: 37 givenname: Onphirul surname: Yurachai fullname: Yurachai, Onphirul – sequence: 38 givenname: Charlotte Jessica E. surname: Metcalf fullname: Metcalf, Charlotte Jessica E. – sequence: 39 givenname: Malavika surname: Rajeev fullname: Rajeev, Malavika – sequence: 40 givenname: Jesse surname: Blanton fullname: Blanton, Jesse – sequence: 41 givenname: Galileu Barbosa surname: Costa fullname: Costa, Galileu Barbosa – sequence: 42 givenname: Nandini surname: Sreenivasan fullname: Sreenivasan, Nandini – sequence: 43 givenname: Ryan surname: Wallace fullname: Wallace, Ryan – sequence: 44 givenname: Deborah surname: Briggs fullname: Briggs, Deborah – sequence: 45 givenname: Louise surname: Taylor fullname: Taylor, Louise – sequence: 46 givenname: Samuel M. surname: Thumbi fullname: Thumbi, Samuel M. – sequence: 47 givenname: Nguyen Thi Thanh surname: Huong fullname: Huong, Nguyen Thi Thanh
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30472178$$D View this record in MEDLINE/PubMed https://hal.science/hal-02868805$$DView record in HAL
BookMark	eNqNkk9v1DAQxSNURP_ARwBZ4tIeAnbsJA4IUFVBi7QSB8rZcpzJ7pTE3tpJ1JX48Di7pYK9lNNEk9979njecXJgnYUkecnoG0ZZ8fY7EyVPOa2qUybPOM1ZlpZPkqPYFqkQeXmw_d4hh8lxCDeUspJR8Sw55FSUGSvlUfLregVk7QawA-qOQNuCGYhrCfZr7yZoyFwwoLNz1-saIURBGFK4i2X0MBPr1abTdxgIWnKpJ0yhwyXWHRDjRjv4KHpHNOldA12HdknCMDab58nTVncBXtzXk-THl8_XF1fp4tvl14vzRWpyyYe0YLVuTZzDaGkEhZLnGvK6hbYQAFlLqcggM6Vsqjrjpq1orXlGKc8Zr2kF_CT5uPNdj3UPjYnDet2ptcde-41yGtW_fyyu1NJNquDRW9JocLYzWO3Jrs4Xau7RTBZS0nxikT29P8y72xHCoHoMJo6tLbgxqIxxSQUXxYy-3kNv3OhtfIpI5TKnFRdZpF79ffuH8_8sMQL5DjDeheChfUAYVXNY1DYsak6CYlJtw6LKqHu_pzM46CGuOj4Cdo-qP-3UEDc3IXgVDII10KCPGVKNw0cdPuw5mJgNNLr7CZv_0P8GBRntxA
CitedBy_id	crossref_primary_10_1016_j_actatropica_2020_105459 crossref_primary_10_1186_s44149_023_00078_8 crossref_primary_10_1590_0037_8682_0520_2023 crossref_primary_10_1590_s1679_49742021000100010 crossref_primary_10_1016_j_vaccine_2025_127108 crossref_primary_10_1093_infdis_jiz645 crossref_primary_10_3389_fpubh_2022_971967 crossref_primary_10_1016_j_vaccine_2019_05_035 crossref_primary_10_1038_s41577_021_00567_2 crossref_primary_10_1016_j_chaos_2024_115633 crossref_primary_10_1016_j_heliyon_2022_e11366 crossref_primary_10_1016_S1473_3099_23_00499_1 crossref_primary_10_1371_journal_pntd_0008821 crossref_primary_10_1093_trstmh_trad074 crossref_primary_10_1016_j_actatropica_2020_105389 crossref_primary_10_1016_j_ijid_2020_05_062 crossref_primary_10_1016_j_nmni_2023_101098 crossref_primary_10_1016_j_actatropica_2020_105629 crossref_primary_10_3390_ijerph18041736 crossref_primary_10_1155_jama_5559842 crossref_primary_10_1016_j_ijid_2024_01_008 crossref_primary_10_1016_j_actatropica_2021_106223 crossref_primary_10_1186_s12939_024_02207_2 crossref_primary_10_1016_S1473_3099_19_30311_1 crossref_primary_10_1016_S0140_6736_22_02487_4 crossref_primary_10_1080_14712598_2020_1766021 crossref_primary_10_1093_cid_ciaa779 crossref_primary_10_1016_j_actatropica_2019_105180 crossref_primary_10_1371_journal_pntd_0010124 crossref_primary_10_1038_s41598_020_57908_9 crossref_primary_10_1016_j_micpath_2021_104971 crossref_primary_10_1016_S1773_035X_19_30029_2 crossref_primary_10_3389_fpubh_2022_769898 crossref_primary_10_7554_eLife_85262 crossref_primary_10_1038_s41467_023_41110_2 crossref_primary_10_1016_j_actatropica_2020_105484 crossref_primary_10_1016_j_vaccine_2024_126703 crossref_primary_10_12688_gatesopenres_13074_2 crossref_primary_10_12688_gatesopenres_13074_1 crossref_primary_10_1186_s40249_024_01245_w crossref_primary_10_1371_journal_pntd_0011204 crossref_primary_10_1038_s41598_024_76089_3 crossref_primary_10_1016_j_chom_2025_04_018 crossref_primary_10_3389_fvets_2022_866106 crossref_primary_10_1016_j_actatropica_2020_105808 crossref_primary_10_3390_tropicalmed10080222 crossref_primary_10_1073_pnas_2003722118 crossref_primary_10_1016_j_heliyon_2024_e32012 crossref_primary_10_2478_ahem_2023_0026 crossref_primary_10_3892_wasj_2025_378 crossref_primary_10_1371_journal_pntd_0008478 crossref_primary_10_1371_journal_pntd_0009449
Cites_doi	10.3389/fvets.2017.00004 10.3389/fvets.2017.00038 10.1016/S2214-109X(17)30321-2 10.1126/scitranslmed.aaf6984 10.1371/journal.pntd.0000626 10.1371/journal.pmed.1002056 10.1016/S2214-109X(14)70237-2 10.1371/journal.pone.0192313 10.1016/j.actatropica.2015.12.007 10.4269/ajtmh.16-0785 10.1371/journal.pntd.0003786 10.1186/1478-7547-1-8 10.1016/S0264-410X(02)00778-8 10.1126/science.aam8332 10.1016/j.vaccine.2007.08.054 10.1371/journal.pntd.0002372 10.7326/M13-0542 10.1016/j.vaccine.2008.12.037 10.1017/S0266462313000160
ContentType	Journal Article
Contributor	Rajeev, Malavika Chitnis, Nakul Jayme, Sarah Traoré, Abdallah Changalucha, Joel Wallace, Ryan Moyengar, Ronelngar Costa, Galileu Barbosa Mwatondo, Athman Ly, Sowath Cooper, Laura Hampson, Katie Mtema, Zac Thumbi, Samuel M Kotzé, Johann Yurachai, Onphirul Tarantola, Arnaud Lechenne, Monique Blanton, Jesse Muturi, Matthew Edosoa, Glenn T Laager, Mirjam Tenzin, Tenzin Sudarshan, Mysore Kalappa Oussiguéré, Assandi Knopf, Lea Lugelo, Ahmed Sreenivasan, Nandini Ringenier, Moniek Lushasi, Kennedy Bonfoh, Bassirou Mancy, Rebecca Baril, Laurence Briggs, Deborah Taylor, Louise Gunesekera, Amila Andriamandimby, Soa Fy Trotter, Caroline Huong, Nguyen Thi Thanh Ventura, Francesco Metcalf, Charlotte Jessica E Zinsstag, Jakob Hattendorf, Jan Abela-Ridder, Bernadette Narayana, Dh Ashwath Steenson, Rachel Wambura, Gati
Contributor_xml	– sequence: 1 givenname: Katie surname: Hampson fullname: Hampson, Katie – sequence: 2 givenname: Francesco surname: Ventura fullname: Ventura, Francesco – sequence: 3 givenname: Rachel surname: Steenson fullname: Steenson, Rachel – sequence: 4 givenname: Rebecca surname: Mancy fullname: Mancy, Rebecca – sequence: 5 givenname: Caroline surname: Trotter fullname: Trotter, Caroline – sequence: 6 givenname: Laura surname: Cooper fullname: Cooper, Laura – sequence: 7 givenname: Bernadette surname: Abela-Ridder fullname: Abela-Ridder, Bernadette – sequence: 8 givenname: Lea surname: Knopf fullname: Knopf, Lea – sequence: 9 givenname: Moniek surname: Ringenier fullname: Ringenier, Moniek – sequence: 10 givenname: Tenzin surname: Tenzin fullname: Tenzin, Tenzin – sequence: 11 givenname: Sowath surname: Ly fullname: Ly, Sowath – sequence: 12 givenname: Arnaud surname: Tarantola fullname: Tarantola, Arnaud – sequence: 13 givenname: Ronelngar surname: Moyengar fullname: Moyengar, Ronelngar – sequence: 14 givenname: Assandi surname: Oussiguéré fullname: Oussiguéré, Assandi – sequence: 15 givenname: Bassirou surname: Bonfoh fullname: Bonfoh, Bassirou – sequence: 16 givenname: Dh Ashwath surname: Narayana fullname: Narayana, Dh Ashwath – sequence: 17 givenname: Mysore Kalappa surname: Sudarshan fullname: Sudarshan, Mysore Kalappa – sequence: 18 givenname: Matthew surname: Muturi fullname: Muturi, Matthew – sequence: 19 givenname: Athman surname: Mwatondo fullname: Mwatondo, Athman – sequence: 20 givenname: Gati surname: Wambura fullname: Wambura, Gati – sequence: 21 givenname: Soa Fy surname: Andriamandimby fullname: Andriamandimby, Soa Fy – sequence: 22 givenname: Laurence surname: Baril fullname: Baril, Laurence – sequence: 23 givenname: Glenn T surname: Edosoa fullname: Edosoa, Glenn T – sequence: 24 givenname: Abdallah surname: Traoré fullname: Traoré, Abdallah – sequence: 25 givenname: Sarah surname: Jayme fullname: Jayme, Sarah – sequence: 26 givenname: Johann surname: Kotzé fullname: Kotzé, Johann – sequence: 27 givenname: Amila surname: Gunesekera fullname: Gunesekera, Amila – sequence: 28 givenname: Nakul surname: Chitnis fullname: Chitnis, Nakul – sequence: 29 givenname: Jan surname: Hattendorf fullname: Hattendorf, Jan – sequence: 30 givenname: Mirjam surname: Laager fullname: Laager, Mirjam – sequence: 31 givenname: Monique surname: Lechenne fullname: Lechenne, Monique – sequence: 32 givenname: Jakob surname: Zinsstag fullname: Zinsstag, Jakob – sequence: 33 givenname: Joel surname: Changalucha fullname: Changalucha, Joel – sequence: 34 givenname: Zac surname: Mtema fullname: Mtema, Zac – sequence: 35 givenname: Ahmed surname: Lugelo fullname: Lugelo, Ahmed – sequence: 36 givenname: Kennedy surname: Lushasi fullname: Lushasi, Kennedy – sequence: 37 givenname: Onphirul surname: Yurachai fullname: Yurachai, Onphirul – sequence: 38 givenname: Charlotte Jessica E surname: Metcalf fullname: Metcalf, Charlotte Jessica E – sequence: 39 givenname: Malavika surname: Rajeev fullname: Rajeev, Malavika – sequence: 40 givenname: Jesse surname: Blanton fullname: Blanton, Jesse – sequence: 41 givenname: Galileu Barbosa surname: Costa fullname: Costa, Galileu Barbosa – sequence: 42 givenname: Nandini surname: Sreenivasan fullname: Sreenivasan, Nandini – sequence: 43 givenname: Ryan surname: Wallace fullname: Wallace, Ryan – sequence: 44 givenname: Deborah surname: Briggs fullname: Briggs, Deborah – sequence: 45 givenname: Louise surname: Taylor fullname: Taylor, Louise – sequence: 46 givenname: Samuel M surname: Thumbi fullname: Thumbi, Samuel M – sequence: 47 givenname: Nguyen Thi Thanh surname: Huong fullname: Huong, Nguyen Thi Thanh
Copyright	2019 World Health Organization This is an Open Access article published under the CC BY 3.0 IGO license which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any use of this article, there should be no suggestion that WHO endorses any specific organisation, products or services. The use of the WHO logo is not permitted. This notice should be preserved along with the article's original URL. Copyright Elsevier Limited Jan 2019 Attribution 2019 World Health Organization 2019
Copyright_xml	– notice: 2019 World Health Organization – notice: This is an Open Access article published under the CC BY 3.0 IGO license which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any use of this article, there should be no suggestion that WHO endorses any specific organisation, products or services. The use of the WHO logo is not permitted. This notice should be preserved along with the article's original URL. – notice: Copyright Elsevier Limited Jan 2019 – notice: Attribution – notice: 2019 World Health Organization 2019
CorporateAuthor	WHO Rabies Modelling Consortium
CorporateAuthor_xml	– name: WHO Rabies Modelling Consortium
DBID	6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7RV 7U9 7X7 7XB 88E 8AO 8C1 8C2 8FI 8FJ 8FK ABUWG AEUYN AFKRA BENPR C1K CCPQU FYUFA GHDGH H94 K9. KB0 M0S M1P M7N NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI 7X8 1XC VOOES 5PM
DOI	10.1016/S1473-3099(18)30512-7
DatabaseName	ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Nursing & Allied Health Database Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Lancet Titles Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland AUTh Library subscriptions: ProQuest Central Environmental Sciences and Pollution Management ProQuest One Community College Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Health & Medical Collection (Alumni) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition MEDLINE - Academic Hyper Article en Ligne (HAL) Hyper Article en Ligne (HAL) (Open Access) PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Academic Middle East (New) Lancet Titles ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection Environmental Sciences and Pollution Management ProQuest Central ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health Virology and AIDS Abstracts ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	ProQuest One Academic Middle East (New) MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Public Health
EISSN	1474-4457
EndPage	111
ExternalDocumentID	PMC6300480 oai:HAL:hal-02868805v1 30472178 10_1016_S1473_3099_18_30512_7 S1473309918305127
Genre	Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	Cambodia Asia United States--US Africa
GeographicLocations_xml	– name: Cambodia – name: Asia – name: Africa – name: United States--US
GrantInformation	World Health Organization.
GrantInformation_xml	– fundername: Wellcome Trust grantid: 207569/Z/17/Z – fundername: Wellcome Trust grantid: 110330/Z/15/Z
GroupedDBID	--- --K --M -RU ..I .1- .FO 0R~ 123 1B1 1P~ 1~5 29L 4.4 457 4G. 53G 5VS 6PF 7-5 71M 7RV 7X7 88E 8AO 8C1 8C2 8FI 8FJ AAAJQ AAEDT AAEDW AAIKJ AAKOC AALRI AAMRU AAQFI AAQQT AAQXK AARKO AATTM AAWTL AAXKI AAXUO AAYWO ABBQC ABJNI ABMAC ABMZM ABUWG ABWVN ACGFS ACIEU ACLOT ACPRK ACRLP ACRPL ACVFH ADBBV ADCNI ADMUD ADNMO AEIPS AEKER AENEX AEUPX AEUYN AEVXI AFKRA AFPUW AFRAH AFRHN AFTJW AFXIZ AGEKW AGHFR AGQPQ AHMBA AIGII AIIUN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BENPR BKEYQ BKOJK BNPGV BPHCQ BVXVI CCPQU CJTIS CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN FYUFA G-Q GBLVA HF~ HMCUK HVGLF HZ~ IHE J1W KOM M1P M41 MO0 N9A NAPCQ O-L O9- OD- OO. OZT P-8 P-9 P2P PHGZM PHGZT PJZUB PPXIY PQQKQ PROAC PSQYO R2- ROL RPZ SDG SEL SES SPCBC SSH SSI SSZ T5K TLN UKHRP UV1 WOW XBR Z5R ~HD 3V. 6I. AACTN AAFTH AAYOK ABLVK ABYKQ AFKWA AJBFU AJOXV AMFUW RIG SDF ZA5 9DU AAYXX AFFHD CITATION AFCTW AGCQF AGRNS ALIPV CGR CUY CVF ECM EIF NPM 7QL 7U9 7XB 8FK C1K H94 K9. M7N PKEHL PQEST PQUKI 7X8 1XC VOOES 5PM
ID	FETCH-LOGICAL-c583t-61bafc309ca8c40e735ae5bfef64ee2f0042e2c78d9b23cf90ba32003513b09e3
IEDL.DBID	7RV
ISICitedReferencesCount	61
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000453926700043&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1473-3099 1474-4457
IngestDate	Tue Nov 04 01:59:07 EST 2025 Tue Oct 14 20:19:38 EDT 2025 Sun Nov 09 12:09:49 EST 2025 Mon Oct 06 18:36:21 EDT 2025 Mon Jul 21 06:08:15 EDT 2025 Sat Nov 29 07:06:41 EST 2025 Tue Nov 18 22:43:14 EST 2025 Fri Feb 23 02:32:07 EST 2024 Tue Oct 14 19:31:24 EDT 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Language	English
License	This is an open access article under the CC BY IGO license. This is an Open Access article published under the CC BY 3.0 IGO license which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any use of this article, there should be no suggestion that WHO endorses any specific organisation, products or services. The use of the WHO logo is not permitted. This notice should be preserved along with the article's original URL. Attribution: http://creativecommons.org/licenses/by This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c583t-61bafc309ca8c40e735ae5bfef64ee2f0042e2c78d9b23cf90ba32003513b09e3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC6300480 Contributors are listed in the appendix
ORCID	0000-0002-6946-7958 0000-0002-6397-836X
OpenAccessLink	https://pubmed.ncbi.nlm.nih.gov/PMC6300480
PMID	30472178
PQID	2158509342
PQPubID	44001
PageCount	10
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_6300480 hal_primary_oai_HAL_hal_02868805v1 proquest_miscellaneous_2138043461 proquest_journals_2158509342 pubmed_primary_30472178 crossref_primary_10_1016_S1473_3099_18_30512_7 crossref_citationtrail_10_1016_S1473_3099_18_30512_7 elsevier_sciencedirect_doi_10_1016_S1473_3099_18_30512_7 elsevier_clinicalkey_doi_10_1016_S1473_3099_18_30512_7
PublicationCentury	2000
PublicationDate	January 2019 2019-01-00 20190101 2019-01
PublicationDateYYYYMMDD	2019-01-01
PublicationDate_xml	– month: 01 year: 2019 text: January 2019
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: London
PublicationTitle	The Lancet infectious diseases
PublicationTitleAlternate	Lancet Infect Dis
PublicationYear	2019
Publisher	Elsevier Ltd Elsevier Limited New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001 Elsevier Science ;, The Lancet Pub. Group
Publisher_xml	– name: Elsevier Ltd – name: Elsevier Limited – name: New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001 – name: Elsevier Science ;, The Lancet Pub. Group
References	(bib4) 2018; 16 Beyene, Mourits, Kidane, Hogeveen (bib19) 2018; 13 Mindekem, Lechenne, Naissengar (bib29) 2017; 4 bib36 bib15 Hampson K, Abela-Ridder B, Bharti OK, et al. Modelling to inform prophylaxis regimens to prevent human rabies. Taylor, Abela-Ridder, Fahrion, Hampson, Nel (bib8) 2017; 165 Jit, Brisson, Portnoy, Hutubessy (bib28) 2014; 2 Knobel, Cleaveland, Coleman (bib1) 2005; 83 Del Rio Vilas, Freire de Carvalho, Vigilato (bib33) 2017; 4 Hampson, Coudeville, Lembo (bib2) 2015; 9 Changalucha, Grieve, Lushasi (bib18) 2018 Halliday, Hampson, Hanley (bib35) 2017; 357 Undurraga, Meltzer, Tran (bib12) 2017; 96 (in press). (bib27) 2018; 1021 Fitzpatrick, Hampson, Cleaveland (bib34) 2014; 160 (bib16) 2017 Etheart, Kligerman, Augustin (bib13) 2017; 5 Wilde (bib26) 2007; 25 Lembo, Hampson, Kaare (bib11) 2010; 4 Cleaveland, Kaare, Tiringa, Mlengeya, Barrat (bib30) 2003; 21 Tarantola A, Ly S, Chan M, et al. Intradermal rabies post-exposure prophylaxis can be abridged with no measurable impact on clinical outcome in Cambodia, 2003–2014. Zinsstag, Lechenne, Laager (bib32) 2017; 9 bib7 Baltazard, Ghodssi (bib24) 1954; 10 bib5 Stevens, Alkema, Black (bib9) 2016; 13 bib6 bib3 bib17 Griffiths, Korczak, Ayalew, Yigzaw (bib22) 2009; 27 Hutubessy, Chisholm, Edejer (bib23) 2003; 1 Hampson, Abela-Ridder, Brunker (bib20) 2016 Townsend, Sumantra, Pudjiatmoko (bib31) 2013; 7 Husereau, Drummond, Petrou (bib10) 2013; 29 (bib14) 2017 Mindekem (10.1016/S1473-3099(18)30512-7_bib29) 2017; 4 (10.1016/S1473-3099(18)30512-7_bib16) 2017 Griffiths (10.1016/S1473-3099(18)30512-7_bib22) 2009; 27 Etheart (10.1016/S1473-3099(18)30512-7_bib13) 2017; 5 (10.1016/S1473-3099(18)30512-7_bib27) 2018; 1021 Zinsstag (10.1016/S1473-3099(18)30512-7_bib32) 2017; 9 Taylor (10.1016/S1473-3099(18)30512-7_bib8) 2017; 165 Knobel (10.1016/S1473-3099(18)30512-7_bib1) 2005; 83 Halliday (10.1016/S1473-3099(18)30512-7_bib35) 2017; 357 Cleaveland (10.1016/S1473-3099(18)30512-7_bib30) 2003; 21 Changalucha (10.1016/S1473-3099(18)30512-7_bib18) 2018 Fitzpatrick (10.1016/S1473-3099(18)30512-7_bib34) 2014; 160 Hampson (10.1016/S1473-3099(18)30512-7_bib2) 2015; 9 Hutubessy (10.1016/S1473-3099(18)30512-7_bib23) 2003; 1 Townsend (10.1016/S1473-3099(18)30512-7_bib31) 2013; 7 (10.1016/S1473-3099(18)30512-7_bib4) 2018; 16 Wilde (10.1016/S1473-3099(18)30512-7_bib26) 2007; 25 Stevens (10.1016/S1473-3099(18)30512-7_bib9) 2016; 13 Husereau (10.1016/S1473-3099(18)30512-7_bib10) 2013; 29 Hampson (10.1016/S1473-3099(18)30512-7_bib20) 2016 Del Rio Vilas (10.1016/S1473-3099(18)30512-7_bib33) 2017; 4 Undurraga (10.1016/S1473-3099(18)30512-7_bib12) 2017; 96 Baltazard (10.1016/S1473-3099(18)30512-7_bib24) 1954; 10 Jit (10.1016/S1473-3099(18)30512-7_bib28) 2014; 2 Beyene (10.1016/S1473-3099(18)30512-7_bib19) 2018; 13 Lembo (10.1016/S1473-3099(18)30512-7_bib11) 2010; 4 10.1016/S1473-3099(18)30512-7_bib25 10.1016/S1473-3099(18)30512-7_bib21 30472177 - Lancet Infect Dis. 2019 Jan;19(1):12-13. doi: 10.1016/S1473-3099(18)30606-6.
References_xml	– volume: 96 start-page: 1307 year: 2017 end-page: 1317 ident: bib12 article-title: Cost-effectiveness evaluation of a novel integrated bite case management program for the control of human rabies, Haiti 2014–2015 publication-title: Am JTrop Med Hyg – ident: bib15 – year: 2017 ident: bib14 – volume: 357 start-page: 146 year: 2017 end-page: 148 ident: bib35 article-title: Driving improvements in emerging disease surveillance through locally-relevant capacity strengthening publication-title: Science – volume: 165 start-page: 133 year: 2017 end-page: 140 ident: bib8 article-title: Difficulties in estimating the human burden of canine rabies publication-title: Acta Trop – volume: 27 start-page: 1426 year: 2009 end-page: 1432 ident: bib22 article-title: Incremental system costs of introducing combined DTwP-hepatitis B-Hib vaccine into national immunization services in Ethiopia publication-title: Vaccine – ident: bib6 article-title: WHO Strategic Advisory Group of Experts Working Group on rabies vaccines and rabies immunoglobulins (July 2016 to April 2018). Immunizations, vaccines and biologicals – ident: bib17 article-title: Health economics. Health delivery costs – year: 2017 ident: bib16 article-title: WHO methods and data sources for global burden of disease estimates 2000–2015 – volume: 4 start-page: 4 year: 2017 ident: bib33 article-title: Tribulations of the last mile: sides from a regional program publication-title: Front Vet Sci – volume: 4 start-page: 38 year: 2017 ident: bib29 article-title: Cost description and comparative cost efficiency of post-exposure prophylaxis and canine mass vaccination against rabies in N'Djamena, Chad publication-title: Front Vet Sci – volume: 29 start-page: 117 year: 2013 end-page: 122 ident: bib10 article-title: Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement publication-title: Int J Technol Assess Health Care – volume: 4 start-page: e626 year: 2010 ident: bib11 article-title: The feasibility of canine rabies elimination in Africa: dispelling doubts with data publication-title: Plos Neglected Tropical Diseases – volume: 1021 start-page: 1 year: 2018 end-page: 195 ident: bib27 article-title: WHO expert consultation on rabies, third report publication-title: World Health Organ Tech Rep Ser – volume: 25 start-page: 7605 year: 2007 end-page: 7609 ident: bib26 article-title: Failures of post-exposure rabies prophylaxis publication-title: Vaccine – reference: Hampson K, Abela-Ridder B, Bharti OK, et al. Modelling to inform prophylaxis regimens to prevent human rabies. – volume: 9 start-page: e0003786 year: 2015 ident: bib2 article-title: Estimating the global burden of endemic canine rabies publication-title: PLoS Negl Trop Dis – year: 2016 ident: bib20 article-title: Surveillance to establish elimination of transmission and freedom from dog-mediated rabies publication-title: BioRxiv – volume: 160 start-page: 91 year: 2014 end-page: 100 ident: bib34 article-title: Cost-effectiveness of canine vaccination to prevent human rabies in rural Tanzania publication-title: Ann Intern Med – ident: bib7 article-title: Rabies vaccine investment strategy – year: 2018 ident: bib18 article-title: The need to improve access to rabies post-exposure vaccines: lessons from Tanzania publication-title: Vaccine – volume: 2 start-page: e406 year: 2014 end-page: e414 ident: bib28 article-title: Cost-effectiveness of female human papillomavirus vaccination in 179 countries: a PRIME modelling study publication-title: Lancet Glob Health – volume: 10 start-page: 797 year: 1954 end-page: 803 ident: bib24 article-title: Prevention of human rabies; treatment of persons bitten by rabid wolves in Iran publication-title: Bull World Health Organ – volume: 7 start-page: e2372 year: 2013 ident: bib31 article-title: Designing programs for eliminating canine rabies from islands: Bali, Indonesia as a case study publication-title: PLos Negl Trop Dis – ident: bib5 article-title: Zero by 30: the global strategic plan to end human deaths from dog-mediated rabies by 2030 – volume: 13 start-page: e1002056 year: 2016 ident: bib9 article-title: Guidelines for accurate and transparent health estimates reporting: the GATHER statement publication-title: PLoS Med – volume: 5 start-page: e1017 year: 2017 end-page: e1025 ident: bib13 article-title: Effect of counselling on health-care-seeking behaviours and rabies vaccination adherence after dog bites in Haiti, 2014–15: a retrospective follow-up survey publication-title: Lancet Glob Health – volume: 9 start-page: eaaf6984 year: 2017 ident: bib32 article-title: Vaccination of dogs in an African city interrupts rabies transmission and reduces human exposure publication-title: Sci Transl Med – volume: 16 start-page: 201 year: 2018 end-page: 220 ident: bib4 article-title: Rabies vaccines: WHO position paper publication-title: Wkly Epidemiol Rec – ident: bib36 article-title: Financial reports – volume: 13 start-page: e0192313 year: 2018 ident: bib19 article-title: Estimating the burden of rabies in Ethiopia by tracing dog bite victims publication-title: PLoS One – reference: Tarantola A, Ly S, Chan M, et al. Intradermal rabies post-exposure prophylaxis can be abridged with no measurable impact on clinical outcome in Cambodia, 2003–2014. – volume: 21 start-page: 1965 year: 2003 end-page: 1973 ident: bib30 article-title: A dog rabies vaccination campaign in rural Africa: impact on the incidence of dog rabies and human dog-bite injuries publication-title: Vaccine – volume: 83 start-page: 360 year: 2005 end-page: 368 ident: bib1 article-title: Re-evaluating the burden of rabies in Africa and Asia publication-title: Bull World Health Organ – volume: 1 start-page: 8 year: 2003 ident: bib23 article-title: Generalized cost-effectiveness analysis for national-level priority-setting in the health sector publication-title: Cost Eff Resour Alloc – ident: bib3 article-title: Zero by 30: the global strategic plan to end human deaths from dog-mediated rabies by 2030 – reference: (in press). – volume: 4 start-page: 4 year: 2017 ident: 10.1016/S1473-3099(18)30512-7_bib33 article-title: Tribulations of the last mile: sides from a regional program publication-title: Front Vet Sci doi: 10.3389/fvets.2017.00004 – volume: 4 start-page: 38 year: 2017 ident: 10.1016/S1473-3099(18)30512-7_bib29 article-title: Cost description and comparative cost efficiency of post-exposure prophylaxis and canine mass vaccination against rabies in N'Djamena, Chad publication-title: Front Vet Sci doi: 10.3389/fvets.2017.00038 – volume: 5 start-page: e1017 year: 2017 ident: 10.1016/S1473-3099(18)30512-7_bib13 article-title: Effect of counselling on health-care-seeking behaviours and rabies vaccination adherence after dog bites in Haiti, 2014–15: a retrospective follow-up survey publication-title: Lancet Glob Health doi: 10.1016/S2214-109X(17)30321-2 – volume: 9 start-page: eaaf6984 year: 2017 ident: 10.1016/S1473-3099(18)30512-7_bib32 article-title: Vaccination of dogs in an African city interrupts rabies transmission and reduces human exposure publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aaf6984 – volume: 4 start-page: e626 year: 2010 ident: 10.1016/S1473-3099(18)30512-7_bib11 article-title: The feasibility of canine rabies elimination in Africa: dispelling doubts with data publication-title: Plos Neglected Tropical Diseases doi: 10.1371/journal.pntd.0000626 – volume: 13 start-page: e1002056 year: 2016 ident: 10.1016/S1473-3099(18)30512-7_bib9 article-title: Guidelines for accurate and transparent health estimates reporting: the GATHER statement publication-title: PLoS Med doi: 10.1371/journal.pmed.1002056 – volume: 2 start-page: e406 year: 2014 ident: 10.1016/S1473-3099(18)30512-7_bib28 article-title: Cost-effectiveness of female human papillomavirus vaccination in 179 countries: a PRIME modelling study publication-title: Lancet Glob Health doi: 10.1016/S2214-109X(14)70237-2 – volume: 13 start-page: e0192313 year: 2018 ident: 10.1016/S1473-3099(18)30512-7_bib19 article-title: Estimating the burden of rabies in Ethiopia by tracing dog bite victims publication-title: PLoS One doi: 10.1371/journal.pone.0192313 – volume: 83 start-page: 360 year: 2005 ident: 10.1016/S1473-3099(18)30512-7_bib1 article-title: Re-evaluating the burden of rabies in Africa and Asia publication-title: Bull World Health Organ – volume: 165 start-page: 133 year: 2017 ident: 10.1016/S1473-3099(18)30512-7_bib8 article-title: Difficulties in estimating the human burden of canine rabies publication-title: Acta Trop doi: 10.1016/j.actatropica.2015.12.007 – volume: 96 start-page: 1307 year: 2017 ident: 10.1016/S1473-3099(18)30512-7_bib12 article-title: Cost-effectiveness evaluation of a novel integrated bite case management program for the control of human rabies, Haiti 2014–2015 publication-title: Am JTrop Med Hyg doi: 10.4269/ajtmh.16-0785 – volume: 9 start-page: e0003786 year: 2015 ident: 10.1016/S1473-3099(18)30512-7_bib2 article-title: Estimating the global burden of endemic canine rabies publication-title: PLoS Negl Trop Dis doi: 10.1371/journal.pntd.0003786 – volume: 1 start-page: 8 year: 2003 ident: 10.1016/S1473-3099(18)30512-7_bib23 article-title: Generalized cost-effectiveness analysis for national-level priority-setting in the health sector publication-title: Cost Eff Resour Alloc doi: 10.1186/1478-7547-1-8 – volume: 21 start-page: 1965 year: 2003 ident: 10.1016/S1473-3099(18)30512-7_bib30 article-title: A dog rabies vaccination campaign in rural Africa: impact on the incidence of dog rabies and human dog-bite injuries publication-title: Vaccine doi: 10.1016/S0264-410X(02)00778-8 – volume: 357 start-page: 146 year: 2017 ident: 10.1016/S1473-3099(18)30512-7_bib35 article-title: Driving improvements in emerging disease surveillance through locally-relevant capacity strengthening publication-title: Science doi: 10.1126/science.aam8332 – volume: 25 start-page: 7605 year: 2007 ident: 10.1016/S1473-3099(18)30512-7_bib26 article-title: Failures of post-exposure rabies prophylaxis publication-title: Vaccine doi: 10.1016/j.vaccine.2007.08.054 – volume: 7 start-page: e2372 year: 2013 ident: 10.1016/S1473-3099(18)30512-7_bib31 article-title: Designing programs for eliminating canine rabies from islands: Bali, Indonesia as a case study publication-title: PLos Negl Trop Dis doi: 10.1371/journal.pntd.0002372 – year: 2017 ident: 10.1016/S1473-3099(18)30512-7_bib16 – year: 2018 ident: 10.1016/S1473-3099(18)30512-7_bib18 article-title: The need to improve access to rabies post-exposure vaccines: lessons from Tanzania publication-title: Vaccine – ident: 10.1016/S1473-3099(18)30512-7_bib25 – volume: 1021 start-page: 1 year: 2018 ident: 10.1016/S1473-3099(18)30512-7_bib27 article-title: WHO expert consultation on rabies, third report publication-title: World Health Organ Tech Rep Ser – year: 2016 ident: 10.1016/S1473-3099(18)30512-7_bib20 article-title: Surveillance to establish elimination of transmission and freedom from dog-mediated rabies publication-title: BioRxiv – ident: 10.1016/S1473-3099(18)30512-7_bib21 – volume: 160 start-page: 91 year: 2014 ident: 10.1016/S1473-3099(18)30512-7_bib34 article-title: Cost-effectiveness of canine vaccination to prevent human rabies in rural Tanzania publication-title: Ann Intern Med doi: 10.7326/M13-0542 – volume: 16 start-page: 201 year: 2018 ident: 10.1016/S1473-3099(18)30512-7_bib4 article-title: Rabies vaccines: WHO position paper publication-title: Wkly Epidemiol Rec – volume: 27 start-page: 1426 year: 2009 ident: 10.1016/S1473-3099(18)30512-7_bib22 article-title: Incremental system costs of introducing combined DTwP-hepatitis B-Hib vaccine into national immunization services in Ethiopia publication-title: Vaccine doi: 10.1016/j.vaccine.2008.12.037 – volume: 29 start-page: 117 year: 2013 ident: 10.1016/S1473-3099(18)30512-7_bib10 article-title: Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement publication-title: Int J Technol Assess Health Care doi: 10.1017/S0266462313000160 – volume: 10 start-page: 797 year: 1954 ident: 10.1016/S1473-3099(18)30512-7_bib24 article-title: Prevention of human rabies; treatment of persons bitten by rabid wolves in Iran publication-title: Bull World Health Organ – reference: 30472177 - Lancet Infect Dis. 2019 Jan;19(1):12-13. doi: 10.1016/S1473-3099(18)30606-6.
SSID	ssj0017104
Score	2.5510752
Snippet	Tens of thousands of people die from dog-mediated rabies annually. Deaths can be prevented through post-exposure prophylaxis for people who have been bitten,... Summary Background Tens of thousands of people die from dog-mediated rabies annually. Deaths can be prevented through post-exposure prophylaxis for people who... Background: Tens of thousands of people die from dog-mediated rabies annually. Deaths can be prevented through post-exposure prophylaxis for people who have...
SourceID	pubmedcentral hal proquest pubmed crossref elsevier
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	102
SubjectTerms	Animal vaccines Animals Bites and Stings - virology Child, Preschool Cost-Benefit Analysis - methods Costs Dog Diseases - prevention & control Dogs Economic analysis Economic models Endemic Diseases - prevention & control Epidemiology Exposure Fatalities Female Human health and pathology Humans Immunization Immunoglobulins Immunoglobulins - therapeutic use Incidence Infectious diseases Investment policy Life Sciences Low income groups Male Models, Economic Post-Exposure Prophylaxis - economics Post-Exposure Prophylaxis - methods Prevention Production capacity Prophylaxis Quality-Adjusted Life Years Rabies Rabies - epidemiology Rabies - mortality Rabies - prevention & control Rabies - virology Rabies Vaccines - economics Rabies Vaccines - therapeutic use Rabies virus - immunology Rabies virus - isolation & purification Risk assessment Scaling Studies Vaccination - economics Vaccines World Health Organization
Title	The potential effect of improved provision of rabies post-exposure prophylaxis in Gavi-eligible countries: a modelling study
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S1473309918305127 https://dx.doi.org/10.1016/S1473-3099(18)30512-7 https://www.ncbi.nlm.nih.gov/pubmed/30472178 https://www.proquest.com/docview/2158509342 https://www.proquest.com/docview/2138043461 https://hal.science/hal-02868805 https://pubmed.ncbi.nlm.nih.gov/PMC6300480
Volume	19
WOSCitedRecordID	wos000453926700043&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1474-4457 dateEnd: 20251009 omitProxy: false ssIdentifier: ssj0017104 issn: 1473-3099 databaseCode: 7X7 dateStart: 20010801 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1474-4457 dateEnd: 20251009 omitProxy: false ssIdentifier: ssj0017104 issn: 1473-3099 databaseCode: 7RV dateStart: 20010801 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1474-4457 dateEnd: 20251009 omitProxy: false ssIdentifier: ssj0017104 issn: 1473-3099 databaseCode: BENPR dateStart: 20010801 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1474-4457 dateEnd: 20251009 omitProxy: false ssIdentifier: ssj0017104 issn: 1473-3099 databaseCode: 8C1 dateStart: 20010801 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZoixAS4lFegVIZxAEObpPYSRwuqFQtPcCqKg_tzXIcR420SpZNdtUDP54Z51EWBEXi4khOZtcbfzsznichLw2IBBtrzUIRRUzEImOYPsl0LkzsmzCSRe6aTSSTiZxO09Pe4Nb0YZUDT3SMOq8N2sj3QTRJEG5chG_n3xh2jULvat9CY4NsBagbA56Ts6-jFwGkp_Mqi4QzDqrQZQbP_qdx8lUgXwPoA1A0_ySbNs4xSPJ3DfTXQMqfJNPxnf_9TXfJ7V4npQcdiO6Ra7baJjc-9l73bXKrs-3RLmXpPvkO2KLzusVAI6DrQkJoXdDSWShsTp2hAu1wOLvQGRzHgaBpmb2Ay3Jh8QnY4Jm-KBtaVvS9XpXMRUdnM0tdAws8w7-hmrpePZg0T10p3Afky_HR58MT1ndxYCaSvIWzaaYLA2_aaGmEbxMeaRtlhS1iYW1YINuwoUlknmYhN0XqZ5q7Oq0Bz_zU8odks6or-5hQnxdhKnUAgt2ICCvvpbzgPItiY3lorEfEsH_K9CXOsdPGTI2xbLjtCrddBVK5bVeJR_ZGsnlX4-MqgngAhxoSWIHlKpBCVxHKkbDXcDrN5V9IXwAKx_VhVfCTgw8K50BFjIENR6vAIzsD0FTPixp1iTKPPB9vAxdB15CubL3EZ7j0BRcxfMSjDtPjV6FjFg6u0iPJGtrX1rJ-pyrPXaVyV89N-k_-vqyn5CaooWln2Nohm-1iaZ-R62bVls1i1_2lcZwmbpQwysNgl2y9O5qcnv0ASu1T_Q
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1ba9RAFD60VVQQL_W2WnUUBX2ITTKTZCKIFLVu6bYIrbBv42R2QgNLdt2bFfxN_kbPmVzqKlpf-uDTwiQnGbLfuc65ADwxqBJsrLUXiijyRCwyj8onPT0QJvZNGMl84IZNJPv7st9PP6zA96YWhtIqG5noBPVgZChGvomqSaJy4yJ8Pf7s0dQoOl1tRmhUsNi1X7-gyzZ9tfMW_9-nYbj97vBN16unCngmknyGvlKmc8P91GhphG8THmkbZbnNY2FtmBOMbWgSOUizkJs89TPNXd_QgGd-ajk-dxXOoRxPyNlL-q2DF6C2dqfYIuEeviA9qRjaPGgXnwXyOTJZgIbtn3Th6hElZf5u8f6auPmTJty--r99w2twpba52VbFJNdhxZbrcGGvzipYh8tV7JJVJVk34BvyDhuPZpRIhXRVygsb5axwERg7YC4QQ3FGWp3orLBTJJjOPHuMP_OJpTsQwEN9XExZUbL3elF4Lvs7G1rmBnRQjOIl08zNIqKmAMy1-r0JH8_kW9yCtXJU2jvAfJ6HqdQBGi5GRNRZMOU551kUG8tDYzsgGrwoU7dwp0kiQ9Xm6hHMFMFMBVI5mKmkAy9asnHVw-Q0grgBo2oKdFGlKNSypxHKlrC24CrL7F9IHyPq2_1R1_PuVk_RGprAMaqZaBF0YKMBtqpl7VSdoLoDj9rLKCXp6EuXdjSne7j0BRcxPuJ2xUPtq-jgGR1z2YFkibuW9rJ8pSyOXCd2169O-nf_vq2HcLF7uNdTvZ393XtwCU3utAribcDabDK39-G8WcyK6eSBEycMPp017_0Ash2tnQ
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3da9RAEB_aKkUQP-rXadVVFPQhXpLdJBtBpLSeLa1HQYW-rZu9DQ0cufO-rOBf5l_nzOajnqL1pQ8-HWwyyZL7zc7s7G9mAJ4YNAk21toLRRR5IhaZR-mTnh4IE_smjGQ-cM0mkn5fHh2lhyvwvcmFIVplsya6hXowMhQj76JpkmjcuAi7eU2LONzpvR5_9qiDFJ20Nu00Kojs269fcPs2fbW3g__10zDsvfmwvevVHQY8E0k-w31TpnPD_dRoaYRvEx5pG2W5zWNhbZgTpG1oEjlIs5CbPPUzzV0N0YBnfmo5PncVLiQ85rTxk9stvSRAy-1OtEXCPXxBepo91H3fDj4L5HNUuACd3D_ZxdVjImj-7v3-SuL8ySr2rv7P3_MaXKl9cbZVKc91WLHlBqy_q9kGG3C5immyKlXrBnxDnWLj0YwIVihXUWHYKGeFi8zYAXMBGoo_0uhEZ4WdosB05tkT_JlPLN2BwB7qk2LKipK91YvCc6zwbGiZa9xBsYuXTDPXo4iKBTBXAvgmfDyXb3EL1spRae8A83keplIH6NAYEVHFwZTnnGdRbCwPje2AaLCjTF3anTqMDFXL4SPIKYKcCqRykFNJB160YuOqtslZAnEDTNUk7qKpUWh9zxKUrWDt2VUe27-IPkYNaOdH1dB3tw4UjaFrHKP5iRZBBzYbkKt6DZ6qU4R34FF7GVdPOhLTpR3N6R4ufcFFjI-4XelT-yo6kMYNu-xAsqRpS3NZvlIWx65Cu6tjJ_27f5_WQ1hHlVMHe_39e3AJPfG0iu1twtpsMrf34aJZzIrp5IFbWRh8Om_V-wGrrrYk
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+potential+effect+of+improved+provision+of+rabies+post-exposure+prophylaxis+in+Gavi-eligible+countries%3A+a+modelling+study&rft.jtitle=The+Lancet+infectious+diseases&rft.au=Hampson%2C+Katie&rft.au=Ventura%2C+Francesco&rft.au=Steenson%2C+Rachel&rft.au=Mancy%2C+Rebecca&rft.date=2019-01-01&rft.issn=1473-3099&rft.volume=19&rft.issue=1&rft.spage=102&rft.epage=111&rft_id=info:doi/10.1016%2FS1473-3099%2818%2930512-7&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_S1473_3099_18_30512_7
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1473-3099&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1473-3099&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1473-3099&client=summon