The diverse functions of the PD1 inhibitory pathway

Key Points Programmed cell death protein 1 (PD1) is an inhibitory receptor that is expressed by all T cells during activation. It regulates T cell effector functions during various physiological responses, including acute and chronic infection, cancer and autoimmunity, and in immune homeostasis. PD1...

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Bibliographic Details
Published in:	Nature reviews. Immunology Vol. 18; no. 3; pp. 153 - 167
Main Authors:	Sharpe, Arlene H., Pauken, Kristen E.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.03.2018 Nature Publishing Group
Subjects:	631/250/1619/554 631/250/580 631/67/1059/2325 Antibodies, Monoclonal - therapeutic use Antineoplastic Agents, Immunological - therapeutic use Apoptosis Autoimmunity Autoimmunity - immunology B-Lymphocytes - immunology Biomedicine Cancer Cancer immunotherapy Cancer treatment CD4 antigen CD8 antigen Cell activation Cell death Cellular proteins Chronic infection Enzyme regulation Genetic aspects Health aspects Homeostasis Humans Immune checkpoint Immune response Immunological tolerance Immunology Immunoregulation Immunotherapy Immunotherapy - methods Innovations Killer Cells, Natural - immunology Lymphocyte Activation - immunology Lymphocytes Lymphocytes B Lymphocytes T Lymphoid tissue Major histocompatibility complex Mortality Natural killer cells Neoplasms - drug therapy Patients PD-1 protein Physiological responses Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - metabolism review-article Signal Transduction - immunology T cell receptors T-Lymphocytes - immunology Transplantation Tumors
ISSN:	1474-1733, 1474-1741, 1474-1741
Online Access:	Get full text
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