The diverse functions of the PD1 inhibitory pathway

T cell activation is a highly regulated process involving peptide-MHC engagement of the T cell receptor and positive costimulatory signals. Upon activation, coinhibitory 'checkpoints', including programmed cell death protein 1 (PD1), become induced to regulate T cells. PD1 has an essential...

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Vydáno v:	Nature reviews. Immunology Ročník 18; číslo 3; s. 153 - 167
Hlavní autoři:	Sharpe, Arlene H, Pauken, Kristen E
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.03.2018
Témata:	Antibodies, Monoclonal - therapeutic use Antineoplastic Agents, Immunological - therapeutic use Apoptosis Autoimmunity Autoimmunity - immunology B-Lymphocytes - immunology Cancer Cancer immunotherapy CD4 antigen CD8 antigen Cell activation Cell death Chronic infection Homeostasis Humans Immune checkpoint Immune response Immunological tolerance Immunoregulation Immunotherapy Immunotherapy - methods Killer Cells, Natural - immunology Lymphocyte Activation - immunology Lymphocytes Lymphocytes B Lymphocytes T Lymphoid tissue Major histocompatibility complex Mortality Natural killer cells Neoplasms - drug therapy Patients PD-1 protein Physiological responses Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - metabolism Signal Transduction - immunology T cell receptors T-Lymphocytes - immunology Transplantation Tumors
ISSN:	1474-1733, 1474-1741, 1474-1741
On-line přístup:	Získat plný text
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