Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify f...

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Vydáno v:	Nature genetics Ročník 51; číslo 3; s. 414 - 430
Hlavní autoři:	Ahmad, Shahzad, Vardarajan, Badri N., Hoffmann, Per, Garnier, Jean-Guillaume, Harold, Denise, Fitzpatrick, Annette L., Valladares, Otto, Smith, Albert V., Qu, Liming, Zhao, Yi, Del Zompo, Maria, Uphill, James, Cantwell, Laura B., Garzia, Fabienne, Fin, Bertrand, Barber, Robert C., Mayhaus, Manuel, Hartmann, Annette M., Lovestone, Simon, Garcia, Melissa E., Fairchild, Thomas J., Karamujić-Čomić, Hata, Frosch, Matthew P., Maier, Wolfgang, Li, Shuo, Huebinger, Ryan M., Kamboh, M. Ilyas, Yang, Qiong, Haapasalo, Annakaisa, Lawlor, Brian, Solfrizzi, Vincenzo, Frisardi, Vincenza, Alvarez, Ignacio, Salani, Francesca, Fievet, Nathalie, Maletta, Raffaele Giovanni, Tsuang, Debby W., Soininen, Hilkka, Avramidou, Despoina, Panza, Francesco, Frölich, Lutz, Passmore, Peter, Schott, Jonathan M., Powell, John F., Burns, Jeffrey M., Hardy, John, Carrasquillo, Minerva M., Crocco, Elizabeth A., Faber, Kelley M., Scherer, Martin, Ferris, Steven, Galasko, Douglas R., Geschwind, Daniel H., Honig, Lawrence S., Cushion, Thomas D., Hollingworth, Paul, Hulette, Christine M., Jessen, Frank, Lah, James J., Leverenz, James B., Morgan, Kevin, Mash, Deborah C., McCurry, Susan M., Miller, Carol A., Shaw, Christopher E., Myers, Amanda J., Paulson, Henry L., Peskind, Elaine, Cribbs, David H., Rossor, Martin, Pierce, Aimee, Potter, Huntington, Sorbi, Sandro, Reitz, Christiane, Ringman, John M., Rosen, Howard J., Mecocci, Patrizia, Slifer, Susan, Spina, Salvatore, Vinters, Harry V., Weintraub, Sandra, Welsh-Bohmer, Kathleen A., Crane, Paul K., Bennett, David, Boccardi, Virginia, Lopez, Oscar L., Deloukas, Panagiotis, Cruchaga, Carlos, Berr, Claudine, Younkin, Steven G., Clarimon, Jordi, Schmidt, Reinhold, Farrer, Lindsay A., Van Broeckhoven, Christine, C. O’Donovan, Michael, Haines, Jonathan L., Gudnason, Vilmundur, Mayeux, Richard, Seshadri, Sudha, Williams, Julie
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.03.2019 Nature Publishing Group
Témata:	38/43 45/91 631/208/199 631/208/205/2138 692/699/375/132/1283 692/699/375/365/1283 ADAMTS-1 protein Age Aged Agriculture Alzheimer Disease - genetics Alzheimer's disease Amyloid beta-Peptides - genetics Amyloid precursor protein Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Consortia Datasets Dementia Dementia disorders Family medical history Female Gene Function Gene loci Gene mapping Genes Genetic analysis Genetic diversity Genetic Loci - genetics Genetic Predisposition to Disease - genetics Genetic Testing - methods Genetic variance Genetics Genome-Wide Association Study - methods Genomes Genomics Haplotypes - genetics Histocompatibility antigen HLA Human Genetics Humans Immunity Immunity (Disease) Immunity - genetics Leukocytes Lipid metabolism Lipid Metabolism - genetics Lipids Lipids - genetics Male Mapping Meta-analysis Metabolism Neurodegenerative diseases Ontology Protein turnover Proteins Risk analysis Risk factors Secretase Tau protein tau Proteins - genetics
ISSN:	1061-4036, 1546-1718, 1546-1718
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