Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease

Cardiovascular risk models remain incomplete. Small-molecule metabolites may reflect underlying disease and, as such, serve as novel biomarkers of cardiovascular risk. We studied 2,023 consecutive patients undergoing cardiac catheterization. Mass spectrometry profiling of 69 metabolites and lipid as...

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Bibliographic Details
Published in:	The American heart journal Vol. 163; no. 5; pp. 844 - 850.e1
Main Authors:	Shah, Svati H., Sun, Jie-Lena, Stevens, Robert D., Bain, James R., Muehlbauer, Michael J., Pieper, Karen S., Haynes, Carol, Hauser, Elizabeth R., Kraus, William E., Granger, Christopher B., Newgard, Christopher B., Califf, Robert M., Newby, L. Kristin
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01.05.2012 Mosby Elsevier Limited
Subjects:	Adult Age Distribution Analysis of Variance Atherosclerosis (general aspects, experimental research) Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Blood Chemical Analysis Cardiac Catheterization - methods Cardiac Catheterization - statistics & numerical data Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cardiovascular Diseases - metabolism Cohort Studies Confidence Intervals Coronary Artery Disease - diagnosis Coronary Artery Disease - epidemiology Coronary Artery Disease - metabolism Coronary heart disease Female Heart Heart attacks Humans Lipids - blood Male Medical sciences Metabolites Metabolomics - methods Middle Aged Mortality Multivariate Analysis Predictive Value of Tests Prevalence Prognosis Retrospective Studies Risk Assessment Severity of Illness Index Sex Distribution Stroke Volume Survival Analysis NRI CI GRACE HR IQR MI IDI MURDOCK CV PCA Global Registry of Acute Coronary Events myocardial infarction net reclassification improvement interquartile range Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis Cardiovascular Study integrated discrimination index hazard ratio confidence interval principal component analysis Vascular disease Human Atherosclerosis Risk factor Patient Cardiovascular disease Circulatory system Cardiology Predictive factor Coronary heart disease Profile
ISSN:	0002-8703, 1097-6744, 1097-6744
Online Access:	Get full text
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