Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial

Craniotomy, according to the results from trials, does not improve functional outcome after intracerebral haemorrhage. Whether minimally invasive catheter evacuation followed by thrombolysis for clot removal is safe and can achieve a good functional outcome is not known. We investigated the safety a...

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Bibliographic Details
Published in:	Lancet neurology Vol. 15; no. 12; pp. 1228 - 1237
Main Authors:	Hanley, Daniel F, Thompson, Richard E, Muschelli, John, Rosenblum, Michael, McBee, Nichol, Lane, Karen, Bistran-Hall, Amanda J, Mayo, Steven W, Keyl, Penelope, Gandhi, Dheeraj, Morgan, Tim C, Ullman, Natalie, Mould, W Andrew, Carhuapoma, J Ricardo, Kase, Carlos, Ziai, Wendy, Thompson, Carol B, Yenokyan, Gayane, Huang, Emily, Broaddus, William C, Graham, R Scott, Aldrich, E Francois, Dodd, Robert, Wijman, Cristanne, Caron, Jean-Louis, Huang, Judy, Camarata, Paul, Mendelow, A David, Gregson, Barbara, Janis, Scott, Vespa, Paul, Martin, Neil, Awad, Issam, Zuccarello, Mario
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.11.2016 Elsevier Limited
Subjects:	Aged Blood pressure Cerebral Hemorrhage - drug therapy Cerebral Hemorrhage - mortality Cerebral Hemorrhage - surgery Coma Combined Modality Therapy Female Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - adverse effects Fibrinolytic Agents - pharmacology Follow-Up Studies Hemorrhage Humans Intensive care Laparoscopy Male Middle Aged Minimally Invasive Surgical Procedures Mortality Neurology Outcome Assessment (Health Care) Patients Postoperative Hemorrhage - etiology Pragmatism Stroke Surgery Surgery, Computer-Assisted Thrombectomy - adverse effects Thrombectomy - methods Tissue Plasminogen Activator - administration & dosage Tissue Plasminogen Activator - adverse effects Tissue Plasminogen Activator - pharmacology
ISSN:	1474-4422, 1474-4465, 1474-4465
Online Access:	Get full text
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