Helicobacter pylori Activates and Expands Lgr5(+) Stem Cells Through Direct Colonization of the Gastric Glands

Helicobacter pylori infection is the main risk factor for gastric cancer. We characterized the interactions of H pylori with gastric epithelial progenitor and stem cells in humans and mice and investigated how these interactions contribute to H pylori-induced pathology. We used quantitative confocal...

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Bibliographic Details
Published in:	Gastroenterology (New York, N.Y. 1943) Vol. 148; no. 7; p. 1392
Main Authors:	Sigal, Michael, Rothenberg, Michael E, Logan, Catriona Y, Lee, Josephine Y, Honaker, Ryan W, Cooper, Rachel L, Passarelli, Ben, Camorlinga, Margarita, Bouley, Donna M, Alvarez, Guillermo, Nusse, Roeland, Torres, Javier, Amieva, Manuel R
Format:	Journal Article
Language:	English
Published:	United States 01.06.2015
Subjects:	Animals Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Biomarkers - metabolism Cell Proliferation Disease Models, Animal Gastric Mucosa - metabolism Gastric Mucosa - microbiology Genotype Helicobacter Infections - immunology Helicobacter Infections - microbiology Helicobacter Infections - pathology Helicobacter pylori - genetics Helicobacter pylori - growth & development Helicobacter pylori - pathogenicity Host-Pathogen Interactions Humans Hyperplasia Kinetics Mice, Inbred C57BL Mice, Transgenic Mutation Organoids Phenotype Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Stem Cells - metabolism Stem Cells - microbiology Stem Cells - pathology Tissue Culture Techniques Virulence Infection Proliferation CagA Progenitor Cells
ISSN:	1528-0012, 1528-0012
Online Access:	Get more information
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