Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis

Pulmonary fibrosis is characterized by accumulation of activated fibroblasts that produce excessive amounts of extracellular matrix components such as collagen type I. However, the dynamics and activation signatures of fibroblasts during fibrogenesis remain poorly understood, especially in vivo. We...

Full description

Saved in:

Bibliographic Details
Published in:	The American journal of pathology Vol. 183; no. 3; p. 758
Main Authors:	Tsukui, Tatsuya, Ueha, Satoshi, Abe, Jun, Hashimoto, Shin-ichi, Shichino, Shigeyuki, Shimaoka, Takeshi, Shand, Francis H W, Arakawa, Yasuka, Oshima, Kenshiro, Hattori, Masahira, Inagaki, Yutaka, Tomura, Michio, Matsushima, Kouji
Format:	Journal Article
Language:	English
Published:	United States 01.09.2013
Subjects:	Animals Apoptosis Biomarkers - metabolism Bleomycin Bone Marrow Cells - pathology Cell Proliferation Collagen Type I - metabolism Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Profiling Gene Ontology Green Fluorescent Proteins - metabolism Lung - metabolism Lung - pathology Mice Mice, Inbred C57BL Osteopontin - metabolism Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Recombinant Fusion Proteins - metabolism Up-Regulation - genetics
ISSN:	1525-2191, 1525-2191
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!