Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis

Pulmonary fibrosis is characterized by accumulation of activated fibroblasts that produce excessive amounts of extracellular matrix components such as collagen type I. However, the dynamics and activation signatures of fibroblasts during fibrogenesis remain poorly understood, especially in vivo. We...

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Vydáno v:	The American journal of pathology Ročník 183; číslo 3; s. 758
Hlavní autoři:	Tsukui, Tatsuya, Ueha, Satoshi, Abe, Jun, Hashimoto, Shin-ichi, Shichino, Shigeyuki, Shimaoka, Takeshi, Shand, Francis H W, Arakawa, Yasuka, Oshima, Kenshiro, Hattori, Masahira, Inagaki, Yutaka, Tomura, Michio, Matsushima, Kouji
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.09.2013
Témata:	Animals Apoptosis Biomarkers - metabolism Bleomycin Bone Marrow Cells - pathology Cell Proliferation Collagen Type I - metabolism Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Profiling Gene Ontology Green Fluorescent Proteins - metabolism Lung - metabolism Lung - pathology Mice Mice, Inbred C57BL Osteopontin - metabolism Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Recombinant Fusion Proteins - metabolism Up-Regulation - genetics
ISSN:	1525-2191, 1525-2191
On-line přístup:	Zjistit podrobnosti o přístupu
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