ATP7B-Deficient Hepatocytes Reveal the Importance of Protein Misfolding Induced at Low Copper Concentration

Copper is a transition metal essential for human life. Its homeostasis is regulated in the liver, which delivers copper to the whole body and excretes its excess outside the organism in the feces through the bile. These functions are regulated within hepatocytes, and the ATP7B copper transporter is...

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Bibliographic Details
Published in:	Cells (Basel, Switzerland) Vol. 11; no. 21; p. 3400
Main Authors:	Charbonnier, Peggy, Chovelon, Benoît, Ravelet, Corinne, Ngo, Tuan Dung, Chevallet, Mireille, Deniaud, Aurélien
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 27.10.2022 MDPI
Subjects:	Adenosine triphosphatase ATP7B Bile Biochemistry, Molecular Biology Cell Line Cell lines Cellular Biology Cloning Copper Copper - metabolism Copper - pharmacology copper homeostasis Copper in the body Copper-Transporting ATPases - genetics Copper-Transporting ATPases - metabolism CRISPR CrispR/Cas9 Development and progression Health aspects Hepatocytes Hepatocytes - metabolism Hepatolenticular Degeneration - genetics Homeostasis Human health and pathology Humans Hépatology and Gastroenterology Life Sciences Liver Liver cells Neural coding Neurological disorders Nutrient interactions Physiological aspects Plasmids Protein folding protein misfolding Proteins Proteostasis Deficiencies - genetics Proteostasis Deficiencies - metabolism Viruses Wilson disease Wilson's disease Zinc finger proteins France ATP7B Wilson disease CrispR/Cas9 copper homeostasis protein misfolding hepatocytes CrispR Cas9
ISSN:	2073-4409, 2073-4409
Online Access:	Get full text
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