Sex-dependent association between angiotensin-converting enzyme insertion/deletion polymorphism and obesity in relation to sodium intake in children

Obesity is a complex condition that is influenced by genetic and environmental factors and is associated with an increased risk for diabetes, hypertension, and cardiovascular diseases. Angiotensin-converting enzyme (ACE) is well characterized in the control of blood pressure. This study investigated...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nutrition (Burbank, Los Angeles County, Calif.) Ročník 29; číslo 3; s. 525 - 530
Hlavní autoři: Yang, Soo Jin, Kim, Sunyoung, Park, Hyesoon, Kim, Seon-Mee, Choi, Kyung-Mook, Lim, Yunsook, Lee, Myoungsook
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York, NY Elsevier Inc 01.03.2013
Elsevier
Elsevier Limited
Témata:
Adiposity
administration & dosage
alleles
Angiotensin-converting enzyme insertion/deletion polymorphism
Biological and medical sciences
Blood Pressure
Body Mass Index
boys
Cardiovascular diseases
Child
Children
Children & youth
Cholesterol
Cross-Sectional Studies
diabetes
Diet
Environmental factors
enzymology
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
gender
Gender-dependent association
Gene Deletion
Gene Frequency
genetics
Genotype
girls
Heterozygote
Humans
Hypertension
Korea (South)
Male
Medical sciences
Metabolic diseases
Metabolic disorders
Mutagenesis, Insertional
Obesity
Obesity - enzymology
Obesity - genetics
odds ratio
peptidyl-dipeptidase A
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic
Polymorphism, Genetic - genetics
Republic of Korea
risk
Sex Factors
Sodium
Sodium intake
Sodium, Dietary
Sodium, Dietary - administration & dosage
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Waist Circumference
Republic of Korea
Korea (South)
Obesity
Gender-dependent association
Adiposity
Angiotensin-converting enzyme insertion/deletion polymorphism
Sodium intake
Human
Enzyme
Nutrition disorder
Sex
Renin angiotensin system
Association
Sodium
Angiotensin
Deletion
Child
Nutritional status
Polymorphism
ISSN:0899-9007, 1873-1244, 1873-1244
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Obesity is a complex condition that is influenced by genetic and environmental factors and is associated with an increased risk for diabetes, hypertension, and cardiovascular diseases. Angiotensin-converting enzyme (ACE) is well characterized in the control of blood pressure. This study investigated whether the ACE insertion/deletion (I/D) polymorphism affects obesity in relation to sodium intake in children. A cross-sectional study was conducted in 1260 elementary schoolchildren (633 boys and 627 girls). Subjects were assessed for the degree of obesity, sodium intake, and ACE I/D genotype, and associations were evaluated between the ACE I/D polymorphism and obesity in relation to sodium intake. Sodium intake was significantly correlated with the obesity index (r = 0.048, P = 0.016) and was particularly high in obese D-carrier boys compared with normal D-carrier boys. D-carrier boys did not show any association with the degree of obesity, whereas D-carrier girls with a high sodium intake exhibited a significant association (odds ratio 0.551, P = 0.042) and a negative correlation between the D allele and obesity as a continuous variable (regression coefficient −3.095, P = 0.020), showing gender-dependent associations between the ACE I/D polymorphism and obesity in relation to sodium intake. These findings demonstrate that the association between the ACE I/D polymorphism and obesity in relation to sodium intake is gender dependent in children.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
content type line 14
ObjectType-Feature-3
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ISSN:0899-9007
1873-1244
1873-1244
DOI:10.1016/j.nut.2012.09.001