Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice

Pulmonary fibrosis (PF) is an intractable disorder with a poor prognosis. Lung macrophages have been reported to regulate both progression and remission of bleomycin-induced diffuse PF. However, it remains unclear how macrophages contribute to silica-induced progressive nodular PF and the associated...

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Bibliographic Details
Published in:	The American journal of pathology Vol. 185; no. 11; p. 2923
Main Authors:	Shichino, Shigeyuki, Abe, Jun, Ueha, Satoshi, Otsuji, Mikiya, Tsukui, Tatsuya, Kosugi-Kanaya, Mizuha, Shand, Francis H W, Hashimoto, Shin-Ichi, Suzuki, Hiroshi I, Morikawa, Teppei, Inagaki, Yutaka, Matsushima, Kouji
Format:	Journal Article
Language:	English
Published:	United States 01.11.2015
Subjects:	Animals Bleomycin - adverse effects Disease Models, Animal Epithelial Cells - pathology Gene Expression Profiling Humans Hydroxyproline - analysis Lung - drug effects Lung - pathology Macrophages, Alveolar - drug effects Macrophages, Alveolar - pathology Mice Mice, Inbred C57BL Monocytes Oligonucleotide Array Sequence Analysis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - pathology Receptors, CCR2 - genetics Receptors, CCR2 - metabolism Silicon Dioxide - adverse effects
ISSN:	1525-2191, 1525-2191
Online Access:	Get more information
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