Bedaquiline plus delamanid for XDR tuberculosis

The combination was initiated in a patient in whom an effective treatment cannot be designed, in the consideration that its potential life-saving benefits outweigh its unknown adverse event risks; in a department in which more than 100 tuberculosis cases a year are admitted to hospital, of which 14...

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Bibliographic Details
Published in:The Lancet infectious diseases Vol. 16; no. 3; p. 294
Main Authors: Lachâtre, Marie, Rioux, Christophe, Dû, Damien Le, Fréchet-Jachym, Mathilde, Veziris, Nicolas, Bouvet, Elisabeth, Yazdanpanah, Yazdan
Format: Journal Article
Language:English
Published: United States Elsevier Ltd 01.03.2016
Elsevier Limited
Subjects:
Antitubercular Agents - therapeutic use
Diarylquinolines - therapeutic use
Extensively Drug-Resistant Tuberculosis - drug therapy
Extensively Drug-Resistant Tuberculosis - surgery
Health Services Accessibility
Humans
Infectious Disease
Infectious diseases
Male
Mycobacterium
Nitroimidazoles - therapeutic use
Oxazoles - therapeutic use
Tuberculosis
ISSN:1473-3099, 1474-4457, 1474-4457
Online Access:Get full text
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Summary:The combination was initiated in a patient in whom an effective treatment cannot be designed, in the consideration that its potential life-saving benefits outweigh its unknown adverse event risks; in a department in which more than 100 tuberculosis cases a year are admitted to hospital, of which 14 cases are multidrug-resistant or XDR disease; after a multisciplinary consultation at the national level; and after patient's informed consent. Conditions for this combination use described by Alberto Matteelli and colleagues2 were therefore fulfilled. [...]this combination was initiated under close cardiac monitoring and was well tolerated over a 6 month period.
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ISSN:1473-3099
1474-4457
1474-4457
DOI:10.1016/S1473-3099(16)00047-5