Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

BCG vaccination in children protects against heterologous infections and improves survival independently of tuberculosis prevention. The phase III ACTIVATE trial assessed whether BCG has similar effects in the elderly. In this double-blind, randomized trial, elderly patients (n = 198) received BCG o...

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Bibliographic Details
Published in:	Cell Vol. 183; no. 2; p. 315
Main Authors:	Giamarellos-Bourboulis, Evangelos J, Tsilika, Maria, Moorlag, Simone, Antonakos, Nikolaos, Kotsaki, Antigone, Domínguez-Andrés, Jorge, Kyriazopoulou, Evdoxia, Gkavogianni, Theologia, Adami, Maria-Evangelia, Damoraki, Georgia, Koufargyris, Panagiotis, Karageorgos, Athanassios, Bolanou, Amalia, Koenen, Hans, van Crevel, Reinout, Droggiti, Dionyssia-Irene, Renieris, George, Papadopoulos, Antonios, Netea, Mihai G
Format:	Journal Article
Language:	English
Published:	United States 15.10.2020
Subjects:	Aged Aged, 80 and over BCG Vaccine - administration & dosage BCG Vaccine - adverse effects BCG Vaccine - immunology Double-Blind Method Female Hospitalization Humans Male Middle Aged Respiratory Tract Infections - immunology Respiratory Tract Infections - prevention & control Virus Diseases - immunology Virus Diseases - prevention & control infection incidence elderly BCG epigenetic modifications cytokines trained immunity respiratory infections vaccination
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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