MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1

Inhibitors of MET have not produced satisfactory outcomes in trials of patients with liver cancer. We investigated the mechanisms of liver tumor resistance to MET inhibitors in mice. We tested the effects of MET inhibitors tivantinib and capmatinib in the mouse hepatocellular carcinoma (HCC) cell li...

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Vydáno v:	Gastroenterology (New York, N.Y. 1943) Ročník 156; číslo 6; s. 1849
Hlavní autoři:	Li, Hui, Li, Chia-Wei, Li, Xiaoqiang, Ding, Qingqing, Guo, Lei, Liu, Shuang, Liu, Chunxiao, Lai, Chien-Chen, Hsu, Jung-Mao, Dong, Qiongzhu, Xia, Weiya, Hsu, Jennifer L, Yamaguchi, Hirohito, Du, Yi, Lai, Yun-Ju, Sun, Xian, Koller, Paul B, Ye, Qinghai, Hung, Mien-Chie
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.05.2019
Témata:	Animals Antibodies, Monoclonal - therapeutic use Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - immunology B7-H1 Antigen - metabolism Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - immunology Cell Line, Tumor Down-Regulation Glycogen Synthase Kinase 3 beta - metabolism Granzymes - metabolism Imidazoles - pharmacology Imidazoles - therapeutic use Liver Neoplasms - drug therapy Liver Neoplasms - enzymology Liver Neoplasms - immunology Male Mice Phosphorylation Proto-Oncogene Proteins c-met - antagonists & inhibitors Proto-Oncogene Proteins c-met - metabolism Pyrrolidinones - pharmacology Pyrrolidinones - therapeutic use Quinolines - pharmacology Quinolines - therapeutic use TNF Receptor-Associated Factor 6 - immunology TNF Receptor-Associated Factor 6 - metabolism Triazines - pharmacology Triazines - therapeutic use Tumor Escape - drug effects Ubiquitination Glycogen Synthase Kinase 3 Programmed Cell Death Ligand 1 Hepatocellular Carcinoma Tumor Necrosis Factor Receptor-Associated Factor 6
ISSN:	1528-0012, 1528-0012
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