Immunogenicity and safety in pigs of PHH-1V, a SARS-CoV-2 RBD fusion heterodimer vaccine candidate

The continuing high global incidence of COVID-19 and the undervaccinated status of billions of persons strongly motivate the development of a new generation of efficacious vaccines. We have developed an adjuvanted vaccine candidate, PHH-1V, based on a protein comprising the receptor binding domain (...

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Bibliographic Details
Published in:	Vaccine Vol. 41; no. 35; pp. 5072 - 5078
Main Authors:	Moros, Alexandra, Prenafeta, Antoni, Barreiro, Antonio, Perozo, Eva, Fernández, Alex, Cañete, Manuel, González, Luis, Garriga, Carme, Pradenas, Edwards, Marfil, Silvia, Blanco, Julià, Cebollada Rica, Paula, Sisteré-Oró, Marta, Meyerhans, Andreas, Prat Cabañas, Teresa, March, Ricard, Ferrer, Laura
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 07.08.2023 Elsevier Limited
Subjects:	Allergy and Immunology Amino acids Animal models Antibodies COVID-19 COVID-19 infection COVID-19 vaccines Disease transmission domain Hogs Humoral immune response humoral immunity IFNγ Immune response Immune response (humoral) Immune system Immunization Immunogenicity Lymphocytes T Males mice Pandemics Proteins RBD Recombinant vaccine Safety SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Swine T-lymphocytes Temperature Vaccines Within-subjects design γ-Interferon COVID-19 IFNγ Humoral immune response SARS-CoV-2 RBD Recombinant vaccine
ISSN:	0264-410X, 1873-2518, 1873-2518
Online Access:	Get full text
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