Intratracheal cell transfer demonstrates the profibrotic potential of resident fibroblasts in pulmonary fibrosis

Pulmonary fibrosis is a devastating disease for which there are few effective therapies. Activated fibroblasts form subepithelial clusters known as fibroblastic foci, which are characterized by excessive collagen deposition. The origin of activated fibroblasts is controversial and needs to be clarif...

Full description

Saved in:

Bibliographic Details
Published in:	The American journal of pathology Vol. 185; no. 11; p. 2939
Main Authors:	Tsukui, Tatsuya, Ueha, Satoshi, Shichino, Shigeyuki, Inagaki, Yutaka, Matsushima, Kouji
Format:	Journal Article
Language:	English
Published:	United States 01.11.2015
Subjects:	Animals Bleomycin - adverse effects Collagen - metabolism Disease Models, Animal Epithelial Cells - metabolism Epithelial Cells - pathology Epithelium - metabolism Epithelium - pathology Female Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation Genes, Reporter Male Mice Mice, Inbred C57BL Mice, Transgenic Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Up-Regulation
ISSN:	1525-2191, 1525-2191
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!