A novel approach for the co-delivery of 5-fluorouracil and everolimus for breast cancer combination therapy: stimuli-responsive chitosan hydrogel embedded with mesoporous silica nanoparticles

Background Breast cancer remains one of the leading causes of death among women globally, with traditional therapies often limited by challenges such as drug resistance and significant side effects. Combination therapies, coupled with nanotechnology-based co-delivery systems, offer enhanced efficacy...

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Bibliographic Details
Published in:	Journal of translational medicine Vol. 23; no. 1; pp. 382 - 18
Main Authors:	Arvejeh, Pooria Mohammadi, Chermahini, Fatemeh Amini, Marincola, Francesco, Taheri, Fatemeh, Mirzaei, Seyed Abbas, Alizadeh, Akram, Deris, Fatemeh, Jafari, Raziyeh, Amiri, Niloufar, Soltani, Amin, Bijad, Elham, Dehkordi, Ebrahim Soleiman, Khosravian, Pegah
Format:	Journal Article
Language:	English
Published:	London BioMed Central 31.03.2025 BioMed Central Ltd BMC
Subjects:	Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Breast cancer Breast neoplasm Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Chemical properties Chitin Chitosan - chemistry Dosage and administration Drug delivery Drug Delivery Systems Drug Liberation Drug therapy Drugs Everolimus - administration & dosage Everolimus - pharmacology Everolimus - therapeutic use Female Fluorouracil Fluorouracil - administration & dosage Fluorouracil - pharmacology Fluorouracil - therapeutic use Health aspects Humans Hydrogels Hydrogels - chemistry Innovations Medicine/Public Health Mesopores Mice Mice, Inbred BALB C Nanobiomaterials & Nanomedicine Nanocomposite Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Porosity Silicon Dioxide - chemistry Synergism Vehicles Iran Drug delivery Nanocomposite Hydrogels Mesopores Synergism Breast neoplasm
ISSN:	1479-5876, 1479-5876
Online Access:	Get full text
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