Are we aware of neural activity in primary visual cortex? A neuropsychological case study

Objective According to a seminal hypothesis stated by Crick and Koch in 1995, one is not aware of neural activity in primary visual cortex (V1) because this region lacks reciprocal connections with prefrontal cortex (PFC). Methods We provide here a neuropsychological illustration of this hypothesis...

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Bibliographic Details
Published in:Annals of clinical and translational neurology Vol. 11; no. 5; pp. 1365 - 1370
Main Authors: Hauw, Fabien, Sangaré, Aude, Munoz‐Musat, Esteban, Meyniel, Claire, Di Donato, Nina, Chokron, Sylvie, Bozon, Frédérique, Naccache, Lionel
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01.05.2024
John Wiley and Sons Inc
Wiley
Subjects:
Adult
Awareness - physiology
Blindness, Cortical - physiopathology
Case Study
consciousness
cortical blindness
Female
Humans
Hypotheses
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Neuropsychology
prefrontal cortex
Prefrontal Cortex - physiology
Prefrontal Cortex - physiopathology
primary visual cortex
Primary Visual Cortex - physiology
Primary Visual Cortex - physiopathology
Semantics
vision
Visual Perception - physiology
vision
primary visual cortex
consciousness
prefrontal cortex
cortical blindness
ISSN:2328-9503, 2328-9503
Online Access:Get full text
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Summary:Objective According to a seminal hypothesis stated by Crick and Koch in 1995, one is not aware of neural activity in primary visual cortex (V1) because this region lacks reciprocal connections with prefrontal cortex (PFC). Methods We provide here a neuropsychological illustration of this hypothesis in a patient with a very rare form of cortical blindness: ventral and dorsal cortical pathways were lesioned bilaterally while V1 areas were partially preserved. Results Visual stimuli escaped conscious perception but still activated V1 regions that were functionally disconnected from PFC. Interpretation These results are consistent with the hypothesis of a causal role of PFC in visual awareness.
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ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.52038