Genomewide Association Study of Severe Covid-19 with Respiratory Failure

During the peak of hospitalizations of patients with severe Covid-19 in Italy and Spain in March, a group of researchers in these and other countries obtained and analyzed samples, resulting in the identification of two chromosomal loci associated with the disorder.

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 383; no. 16; pp. 1522 - 1534
Main Authors:	Ellinghaus, David, Degenhardt, Frauke, Bujanda, Luis, Buti, Maria, Albillos, Agustín, Invernizzi, Pietro, Fernández, Javier, Prati, Daniele, Baselli, Guido, Asselta, Rosanna, Grimsrud, Marit M, Milani, Chiara, Aziz, Fátima, Kässens, Jan, May, Sandra, Wendorff, Mareike, Wienbrandt, Lars, Uellendahl-Werth, Florian, Zheng, Tenghao, Yi, Xiaoli, de Pablo, Raúl, Chercoles, Adolfo G, Palom, Adriana, Garcia-Fernandez, Alba-Estela, Rodriguez-Frias, Francisco, Zanella, Alberto, Bandera, Alessandra, Protti, Alessandro, Aghemo, Alessio, Lleo, Ana, Biondi, Andrea, Caballero-Garralda, Andrea, Gori, Andrea, Tanck, Anja, Carreras Nolla, Anna, Latiano, Anna, Fracanzani, Anna Ludovica, Peschuck, Anna, Julià, Antonio, Pesenti, Antonio, Voza, Antonio, Jiménez, David, Mateos, Beatriz, Nafria Jimenez, Beatriz, Quereda, Carmen, Paccapelo, Cinzia, Gassner, Christoph, Angelini, Claudio, Cea, Cristina, Solier, Aurora, Pestaña, David, Muñiz-Diaz, Eduardo, Sandoval, Elena, Paraboschi, Elvezia M, Navas, Enrique, García Sánchez, Félix, Ceriotti, Ferruccio, Martinelli-Boneschi, Filippo, Peyvandi, Flora, Blasi, Francesco, Téllez, Luis, Blanco-Grau, Albert, Hemmrich-Stanisak, Georg, Grasselli, Giacomo, Costantino, Giorgio, Cardamone, Giulia, Foti, Giuseppe, Aneli, Serena, Kurihara, Hayato, ElAbd, Hesham, My, Ilaria, Galván-Femenia, Iván, Martín, Javier, Erdmann, Jeanette, Ferrusquía-Acosta, Jose, Garcia-Etxebarria, Koldo, Izquierdo-Sanchez, Laura, Bettini, Laura R, Sumoy, Lauro, Terranova, Leonardo, Moreira, Leticia, Santoro, Luigi, Scudeller, Luigia, Mesonero, Francisco, Roade, Luisa, Rühlemann, Malte C, Schaefer, Marco, Carrabba, Maria, Riveiro-Barciela, Mar, Figuera Basso, Maria E, Valsecchi, Maria G, Hernandez-Tejero, María, Acosta-Herrera, Marialbert, D'Angiò, Mariella, Baldini, Marina, Cazzaniga, Marina, Schulzky, Martin, Cecconi, Maurizio, Wittig, Michael, Ciccarelli, Michele
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 15.10.2020
Subjects:	ABO Blood-Group System - genetics ABO system Age Aged Association analysis Blood & organ donations Blood group A Blood group O Blood groups Case-Control Studies CCR9 protein Chromosome 3 Chromosome 9 Chromosomes, Human, Pair 3 - genetics Chromosomes, Human, Pair 9 - genetics Coronaviridae Coronaviruses COVID-19 COVID-19 - complications COVID-19 - genetics Disease Drug dosages Epidemics Ethics Female Genetic factors Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Hospitals Humans Informed consent Italy Male Medical research Middle Aged Mortality Multigene Family Original Pandemics Pathogenesis Phlebotomy Polymorphism, Single Nucleotide Quality control Respiratory failure Respiratory Insufficiency - genetics RNA polymerase SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Single-nucleotide polymorphism Spain Susceptibility Systematic review Ventilators Italy Spain Norway Germany
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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Summary:	During the peak of hospitalizations of patients with severe Covid-19 in Italy and Spain in March, a group of researchers in these and other countries obtained and analyzed samples, resulting in the identification of two chromosomal loci associated with the disorder.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Dr. Ellinghaus and Ms. Degenhardt and Drs. Valenti, Franke, and Karlsen contributed equally to this article. Dr. Franke serves as an author on behalf of the Covid-19 Host Genetics Initiative; members of the Initiative are listed in Supplementary Appendix 1, available at NEJM.org.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2020283