Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

A genome-wide association analysis using data from Chinese individuals combined with a transethnic meta-analysis of Psychiatry Genomics Consortium data identifies 30 new loci for schizophrenia. These analyses improve the fine-mapping of susceptibility loci and implicate multiple pathways in schizoph...

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Veröffentlicht in:Nature genetics Jg. 49; H. 11; S. 1576 - 1583
Hauptverfasser: Li, Zhiqiang, Chen, Jianhua, Yu, Hao, He, Lin, Xu, Yifeng, Zhang, Dai, Yi, Qizhong, Li, Changgui, Li, Xingwang, Shen, Jiawei, Song, Zhijian, Ji, Weidong, Wang, Meng, Zhou, Juan, Chen, Boyu, Liu, Yahui, Wang, Jiqiang, Wang, Peng, Yang, Ping, Wang, Qingzhong, Feng, Guoyin, Liu, Benxiu, Sun, Wensheng, Li, Baojie, He, Guang, Li, Weidong, Wan, Chunling, Xu, Qi, Li, Wenjin, Wen, Zujia, Liu, Ke, Huang, Fang, Ji, Jue, Ripke, Stephan, Yue, Weihua, Sullivan, Patrick F, O'Donovan, Michael C, Shi, Yongyong
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Nature Publishing Group US 01.11.2017
Nature Publishing Group
Schlagworte:
45/43
631/208/205/2138
692/699/476/1799
Agriculture
Alleles
Animal Genetics and Genomics
Asian People
Association analysis
Biomedicine
Cancer Research
Chromosome Mapping
Consortia
Data processing
Diabetes
Etiology
Female
Gene Function
Gene mapping
Gene Regulatory Networks
Genetic aspects
Genetic Loci
Genetic Predisposition to Disease
Genome, Human
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomics
Genotypes
Health aspects
Human Genetics
Humans
Loci
Male
Mental disorders
Meta-analysis
Metabolism
Methods
Population
Protein Interaction Mapping
Psychiatry
Risk Assessment
Risk factors
Schizophrenia
Schizophrenia - ethnology
Schizophrenia - genetics
Schizophrenia - physiopathology
Studies
ISSN:1061-4036, 1546-1718, 1546-1718
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Zusammenfassung:A genome-wide association analysis using data from Chinese individuals combined with a transethnic meta-analysis of Psychiatry Genomics Consortium data identifies 30 new loci for schizophrenia. These analyses improve the fine-mapping of susceptibility loci and implicate multiple pathways in schizophrenia biology. We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese individuals and performed further transancestry meta-analyses with data from the Psychiatry Genomics Consortium (PGC2). Approximately 95% of the genome-wide significant (GWS) index alleles (or their proxies) from the PGC2 study were overrepresented in Chinese schizophrenia cases, including ∼50% that achieved nominal significance and ∼75% that continued to be GWS in the transancestry analysis. The Chinese-only analysis identified seven GWS loci; three of these also were GWS in the transancestry analyses, which identified 109 GWS loci, thus yielding a total of 113 GWS loci (30 novel) in at least one of these analyses. We observed improvements in the fine-mapping resolution at many susceptibility loci. Our results provide several lines of evidence supporting candidate genes at many loci and highlight some pathways for further research. Together, our findings provide novel insight into the genetic architecture and biological etiology of schizophrenia.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1061-4036
1546-1718
1546-1718
DOI:10.1038/ng.3973