A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data

Motivation: The Illumina Infinium 450 k DNA Methylation Beadchip is a prime candidate technology for Epigenome-Wide Association Studies (EWAS). However, a difficulty associated with these beadarrays is that probes come in two different designs, characterized by widely different DNA methylation distr...

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Bibliographic Details

Published in:	Bioinformatics Vol. 29; no. 2; pp. 189 - 196
Main Authors:	Teschendorff, Andrew E., Marabita, Francesco, Lechner, Matthias, Bartlett, Thomas, Tegner, Jesper, Gomez-Cabrero, David, Beck, Stephan
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 15.01.2013
Subjects:	Algorithms Bias Bioinformatics Deoxyribonucleic acid DNA Methylation Mathematical models Methylation Neoplasms - genetics Normal Distribution Nucleic Acid Probes - chemistry Oligonucleotide Array Sequence Analysis - methods Original Papers Quantiles Strategy Transformations
ISSN:	1367-4803, 1367-4811, 1367-4811, 1460-2059
Online Access:	Get full text
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