Development and validation of a genetic probability for venous thromboembolism

Factor V Leiden (FVL) and prothrombin gene mutations (PGMs), as well as recently developed polygenic scores (PGSs), have been consistently associated with venous thromboembolism (VTE) risk in European ancestry populations. This study aimed to develop an optimized risk-assessment tool combining mutat...

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Veröffentlicht in:	Research and practice in thrombosis and haemostasis Jg. 9; H. 4; S. 102876
Hauptverfasser:	Shi, Zhuqing, Mulford, Ashley J., Tran, Huy, Filipczak, Michal, Gao, Song, Xie, Stevie, Lobel, Jason, Wei, Jun, Rifkin, Andrew S., Ashworth, Annabelle, Zheng, Siqun Lilly, Wiske, Clay, Duggan, David, Helfand, Brian T., Qamar, Arman, Sanders, Alan R., Tafur, Alfonso J., Xu, Jianfeng
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.05.2025 Elsevier
Schlagworte:	factor V Leiden (FVL) Hematology Original polygenic score (PGS) prothrombin gene mutations (PGM) reclassification venous thromboembolism (VTE) factor V Leiden (FVL) prothrombin gene mutations (PGM) polygenic score (PGS) venous thromboembolism (VTE) reclassification
ISSN:	2475-0379, 2475-0379
Online-Zugang:	Volltext
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