Computational Modeling of Electroencephalography and Functional Magnetic Resonance Imaging Paradigms Indicates a Consistent Loss of Pyramidal Cell Synaptic Gain in Schizophrenia

Diminished synaptic gain—the sensitivity of postsynaptic responses to neural inputs—may be a fundamental synaptic pathology in schizophrenia. Evidence for this is indirect, however. Furthermore, it is unclear whether pyramidal cells or interneurons (or both) are affected, or how these deficits relat...

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Vydáno v:Biological psychiatry (1969) Ročník 91; číslo 2; s. 202 - 215
Hlavní autoři: Adams, Rick A., Pinotsis, Dimitris, Tsirlis, Konstantinos, Unruh, Leonhardt, Mahajan, Aashna, Horas, Ana Montero, Convertino, Laura, Summerfelt, Ann, Sampath, Hemalatha, Du, Xiaoming Michael, Kochunov, Peter, Ji, Jie Lisa, Repovs, Grega, Murray, John D., Friston, Karl J., Hong, L. Elliot, Anticevic, Alan
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 15.01.2022
Elsevier
Témata:
Archival Report
Auditory steady-state
Computer Simulation
Dynamic causal model
Electroencephalography
Evoked Potentials, Auditory
Humans
Magnetic Resonance Imaging
Mismatch negativity
Psychiatric/Mental Health
Psychosis
Pyramidal Cells
Resting state
Schizophrenia
Schizophrenia - diagnostic imaging
Psychosis
Schizophrenia
Mismatch negativity
Resting state
Dynamic causal model
Auditory steady-state
ISSN:0006-3223, 1873-2402, 1873-2402
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Shrnutí:Diminished synaptic gain—the sensitivity of postsynaptic responses to neural inputs—may be a fundamental synaptic pathology in schizophrenia. Evidence for this is indirect, however. Furthermore, it is unclear whether pyramidal cells or interneurons (or both) are affected, or how these deficits relate to symptoms. People with schizophrenia diagnoses (PScz) (n = 108), their relatives (n = 57), and control subjects (n = 107) underwent 3 electroencephalography (EEG) paradigms—resting, mismatch negativity, and 40-Hz auditory steady-state response—and resting functional magnetic resonance imaging. Dynamic causal modeling was used to quantify synaptic connectivity in cortical microcircuits. Classic group differences in EEG features between PScz and control subjects were replicated, including increased theta and other spectral changes (resting EEG), reduced mismatch negativity, and reduced 40-Hz power. Across all 4 paradigms, characteristic PScz data features were all best explained by models with greater self-inhibition (decreased synaptic gain) in pyramidal cells. Furthermore, disinhibition in auditory areas predicted abnormal auditory perception (and positive symptoms) in PScz in 3 paradigms. First, characteristic EEG changes in PScz in 3 classic paradigms are all attributable to the same underlying parameter change: greater self-inhibition in pyramidal cells. Second, psychotic symptoms in PScz relate to disinhibition in neural circuits. These findings are more commensurate with the hypothesis that in PScz, a primary loss of synaptic gain on pyramidal cells is then compensated by interneuron downregulation (rather than the converse). They further suggest that psychotic symptoms relate to this secondary downregulation.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-3223
1873-2402
1873-2402
DOI:10.1016/j.biopsych.2021.07.024