Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging

Summary Mitochondrial function in human skeletal muscle declines with age. Most evidence for this decline comes from studies that assessed mitochondrial function indirectly, and the impact of such deterioration with respect to physical function has not been clearly delineated. We hypothesized that m...

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Bibliographic Details
Published in:Aging cell Vol. 17; no. 2
Main Authors: Gonzalez‐Freire, Marta, Scalzo, Paul, D'Agostino, Jarod, Moore, Zenobia A., Diaz‐Ruiz, Alberto, Fabbri, Elisa, Zane, Ariel, Chen, Brian, Becker, Kevin G., Lehrmann, Elin, Zukley, Linda, Chia, Chee W., Tanaka, Toshiko, Coen, Paul M., Bernier, Michel, Cabo, Rafael, Ferrucci, Luigi
Format: Journal Article
Language:English
Published: England John Wiley & Sons, Inc 01.04.2018
John Wiley and Sons Inc
Subjects:
Adult
Age
Aged
Aged, 80 and over
Aging
Cardiorespiratory fitness
Cardiorespiratory Fitness - physiology
Electron transport
Exercise
Female
Gait
Gene expression
Humans
Knee
Longitudinal Studies
Magnetic resonance spectroscopy
Male
Middle Aged
Mitochondria
Mitochondria, Muscle - metabolism
Mitochondrial DNA
muscle performance
Muscle strength
Muscle Strength - physiology
Muscle, Skeletal - metabolism
Muscles
Musculoskeletal system
Original
Oxidation-Reduction
oxidative capacity
Oxygen consumption
Oxygen Consumption - physiology
Phosphocreatine
Physical fitness
Respiration
Skeletal muscle
Statistics
Transcription
Young Adult
United States > US
Baltimore Maryland
aging
muscle performance
skeletal muscle
mitochondria
oxidative capacity
ISSN:1474-9718, 1474-9726, 1474-9726
Online Access:Get full text
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Summary:Summary Mitochondrial function in human skeletal muscle declines with age. Most evidence for this decline comes from studies that assessed mitochondrial function indirectly, and the impact of such deterioration with respect to physical function has not been clearly delineated. We hypothesized that mitochondrial respiration in permeabilized human muscle fibers declines with age and correlates with phosphocreatine postexercise recovery rate (kPCr), muscle performance, and aerobic fitness. Mitochondrial respiration was assessed by high‐resolution respirometry in saponin‐permeabilized fibers from vastus lateralis muscle biopsies of 38 participants from the Baltimore Longitudinal Study of Aging (BLSA; 21 men, age 24–91 years) who also had available measures of peak oxygen consumption (VO2max) from treadmill tests, gait speed in different tasks, 31P magnetic resonance spectroscopy, isokinetic knee extension, and grip strength. Results indicated a significant reduction in mitochondrial respiration with age (p < .05) that was independent of other potential confounders. Mitochondrial respiratory capacity was also associated with VO2max, muscle strength, kPCr, and time to complete a 400‐m walk (p < .05). A negative trend toward significance (p = .074) was observed between mitochondrial respiration and BMI. Finally, transcriptional profiling revealed a reduced mRNA expression of mitochondrial gene networks with aging (p < .05). Overall, our findings reinforce the notion that mitochondrial function declines with age and may contribute to age‐associated loss of muscle performance and cardiorespiratory fitness.
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ISSN:1474-9718
1474-9726
1474-9726
DOI:10.1111/acel.12725