Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging

Summary Mitochondrial function in human skeletal muscle declines with age. Most evidence for this decline comes from studies that assessed mitochondrial function indirectly, and the impact of such deterioration with respect to physical function has not been clearly delineated. We hypothesized that m...

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Bibliographic Details
Published in:	Aging cell Vol. 17; no. 2
Main Authors:	Gonzalez‐Freire, Marta, Scalzo, Paul, D'Agostino, Jarod, Moore, Zenobia A., Diaz‐Ruiz, Alberto, Fabbri, Elisa, Zane, Ariel, Chen, Brian, Becker, Kevin G., Lehrmann, Elin, Zukley, Linda, Chia, Chee W., Tanaka, Toshiko, Coen, Paul M., Bernier, Michel, Cabo, Rafael, Ferrucci, Luigi
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.04.2018 John Wiley and Sons Inc
Subjects:	Adult Age Aged Aged, 80 and over Aging Cardiorespiratory fitness Cardiorespiratory Fitness - physiology Electron transport Exercise Female Gait Gene expression Humans Knee Longitudinal Studies Magnetic resonance spectroscopy Male Middle Aged Mitochondria Mitochondria, Muscle - metabolism Mitochondrial DNA muscle performance Muscle strength Muscle Strength - physiology Muscle, Skeletal - metabolism Muscles Musculoskeletal system Original Oxidation-Reduction oxidative capacity Oxygen consumption Oxygen Consumption - physiology Phosphocreatine Physical fitness Respiration Skeletal muscle Statistics Transcription Young Adult United States > US Baltimore Maryland aging muscle performance skeletal muscle mitochondria oxidative capacity
ISSN:	1474-9718, 1474-9726, 1474-9726
Online Access:	Get full text
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