New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

With the development of proteomics and epigenetics, a large number of RNA‐binding proteins (RBPs) have been discovered in recent years, and the interaction between long non‐coding RNAs (lncRNAs) and RBPs has also received increasing attention. It is extremely important to conduct in‐depth research o...

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Vydáno v:Cancer communications (London, England) Ročník 42; číslo 2; s. 117 - 140
Hlavní autoři: Yao, Zi‐Ting, Yang, Yan‐Ming, Sun, Miao‐Miao, He, Yan, Liao, Long, Chen, Kui‐Sheng, Li, Bin
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States John Wiley & Sons, Inc 01.02.2022
John Wiley and Sons Inc
Wiley
Témata:
Binding sites
cancer
cancer epigenetics
Cell cycle
Cyclin-dependent kinases
Dehydrogenases
Epigenesis, Genetic
Epigenetics
Gene expression
Genomes
Growth factors
Humans
interaction network
Kinases
lncRNA‐RBP
long non‐coding RNA
Metastasis
MicroRNAs
Neoplasms - genetics
Neoplasms - metabolism
Prostate cancer
Proteins
Review
Reviews
RNA polymerase
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
RNA‐binding protein
Signal transduction
Stem cells
treatment strategy
RNA-binding protein
interaction network
treatment strategy
cancer
long non-coding RNA
cancer epigenetics
lncRNA-RBP
ISSN:2523-3548, 2523-3548
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Popis
Shrnutí:With the development of proteomics and epigenetics, a large number of RNA‐binding proteins (RBPs) have been discovered in recent years, and the interaction between long non‐coding RNAs (lncRNAs) and RBPs has also received increasing attention. It is extremely important to conduct in‐depth research on the lncRNA‐RBP interaction network, especially in the context of its role in the occurrence and development of cancer. Increasing evidence has demonstrated that lncRNA‐RBP interactions play a vital role in cancer progression; therefore, targeting these interactions could provide new insights for cancer drug discovery. In this review, we discussed how lncRNAs can interact with RBPs to regulate their localization, modification, stability, and activity and discussed the effects of RBPs on the stability, transport, transcription, and localization of lncRNAs. Moreover, we explored the regulation and influence of these interactions on lncRNAs, RBPs, and downstream pathways that are related to cancer development, such as N6‐methyladenosine (m6A) modification of lncRNAs. In addition, we discussed how the lncRNA‐RBP interaction network regulates cancer cell phenotypes, such as proliferation, apoptosis, metastasis, drug resistance, immunity, tumor environment, and metabolism. Furthermore, we summarized the therapeutic strategies that target the lncRNA‐RBP interaction network. Although these treatments are still in the experimental stage and various theories and processes are still being studied, we believe that these strategies may provide new ideas for cancer treatment.
Bibliografie:These authors contributed equally to this work.
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ISSN:2523-3548
2523-3548
DOI:10.1002/cac2.12254