The aging signature: a hallmark of induced pluripotent stem cells?

Summary The discovery that somatic cells can be induced into a pluripotent state by the expression of reprogramming factors has enormous potential for therapeutics and human disease modeling. With regard to aging and rejuvenation, the reprogramming process resets an aged, somatic cell to a more yout...

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Veröffentlicht in:	Aging cell Jg. 13; H. 1; S. 2 - 7
Hauptverfasser:	Rohani, Leili, Johnson, Adiv A., Arnold, Antje, Stolzing, Alexandra
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England John Wiley & Sons, Inc 01.02.2014 BlackWell Publishing Ltd
Schlagworte:	Aging Aging - physiology Animals Cellular Reprogramming Cellular Senescence differentiation Embryonic stem cells epigenetic Epigenetic inheritance Genes Humans induced pluripotent stem Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Mitochondria - metabolism Oxidative Stress reprogramming Review Stem cells Telomerase Telomeres reprogramming differentiation aging induced pluripotent stem epigenetic telomeres
ISSN:	1474-9718, 1474-9726, 1474-9726
Online-Zugang:	Volltext
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