TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-α and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical d...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuroimmunology Vol. 216; no. 1; pp. 92 - 97
Main Authors: Kamer, Angela R., Craig, Ronald G., Pirraglia, Elizabeth, Dasanayake, Ananda P., Norman, Robert G., Boylan, Robert J., Nehorayoff, Andrea, Glodzik, Lidia, Brys, Miroslaw, de Leon, Mony J.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 30.11.2009
Subjects:
Adult
Aged
Allergy and Immunology
Alzheimer Disease - immunology
Alzheimer Disease - microbiology
Alzheimer Disease - physiopathology
Alzheimer's disease
Antibodies - analysis
Antibodies - metabolism
Bacteria - immunology
Biomarkers
Biomarkers - analysis
Biomarkers - metabolism
Causality
Comorbidity
Diagnosis
Diagnosis, Differential
Female
Humans
Inflammation
Male
Middle Aged
Neurology
Periodontal antibodies
Periodontitis - immunology
Periodontitis - microbiology
Periodontitis - physiopathology
Periodontium - immunology
Periodontium - microbiology
Predictive Value of Tests
TNF-α
Tumor Necrosis Factor-alpha - analysis
Tumor Necrosis Factor-alpha - metabolism
Up-Regulation - immunology
Biomarkers
Inflammation
Diagnosis
TNF-α
Periodontal antibodies
Alzheimer's disease
ISSN:0165-5728, 1872-8421, 1872-8421
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-α and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-α and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-α classification of clinical AD and NL. This study shows that TNF-α and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0165-5728
1872-8421
1872-8421
DOI:10.1016/j.jneuroim.2009.08.013