Detection of multidrug-resistance in Mycobacterium tuberculosis by phenotype- and molecular-based assays

Background The whole-genome sequencing (WGS) is becoming an increasingly effective tool for rapid and accurate detection of drug resistance in Mycobacterium tuberculosis complex (MTBC). This approach, however, has still been poorly evaluated on strains from Central and Eastern European countries. Th...

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Veröffentlicht in:	Annals of clinical microbiology and antimicrobials Jg. 23; H. 1; S. 81 - 10
Hauptverfasser:	Vasiliauskaitė, Laima, Bakuła, Zofia, Vasiliauskienė, Edita, Bakonytė, Daiva, Decewicz, Przemysław, Dziurzyński, Mikołaj, Proboszcz, Małgorzata, Davidavičienė, Edita Valerija, Nakčerienė, Birutė, Krenke, Rafał, Kačergius, Tomas, Stakėnas, Petras, Jagielski, Tomasz
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 28.08.2024 BioMed Central Ltd BMC
Schlagworte:	Analysis Antitubercular agents Antitubercular Agents - pharmacology Bacterial Proteins - genetics Biochemistry Biomedical and Life Sciences Biomedicine Catalase - genetics DNA sequencing DNA-Directed RNA Polymerases - genetics Dosage and administration Drug Resistance Drug resistance in microorganisms Drug Resistance, Multiple, Bacterial - genetics Drug susceptibility testing Drug therapy Genetic aspects Humans Infectious Diseases Isoniazid - pharmacology Lithuania MDR-TB Medical Microbiology Microbial Genetics and Genomics Microbial Sensitivity Tests - methods Minimum inhibitory concentration Mutation Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Nucleotide sequencing Oxidoreductases - genetics Parasitology Patient outcomes Phenotype Poland Prevention Rifampin - pharmacology Tuberculosis Tuberculosis, Multidrug-Resistant - microbiology Whole Genome Sequencing Poland Lithuania MDR-TB Drug susceptibility testing Whole-genome sequencing Minimum inhibitory concentration
ISSN:	1476-0711, 1476-0711
Online-Zugang:	Volltext
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